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AGR2 (anterior gradient 2, protein disulphide isomerase family member)

Identity

Alias_namesmember 17
Alias_symbol (synonym)XAG-2
HAG-2
AG2
PDIA17
Other aliasAG-2
GOB-4
HEL-S-116
HPC8
HGNC (Hugo) AGR2
LocusID (NCBI) 10551
Atlas_Id 595
Location 7p21.1  [Link to chromosome band 7p21]
Location_base_pair Starts at 16792640 and ends at 16805114 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGR2 (7p21.1) / CSE1L (20q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Liver: Fibrolamellar carcinoma


External links

Nomenclature
HGNC (Hugo)AGR2   328
Cards
Entrez_Gene (NCBI)AGR2  10551  anterior gradient 2, protein disulphide isomerase family member
AliasesAG-2; AG2; GOB-4; HAG-2; 
HEL-S-116; HPC8; PDIA17; XAG-2
GeneCards (Weizmann)AGR2
Ensembl hg19 (Hinxton)ENSG00000106541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106541 [Gene_View]  chr7:16792640-16805114 [Contig_View]  AGR2 [Vega]
ICGC DataPortalENSG00000106541
TCGA cBioPortalAGR2
AceView (NCBI)AGR2
Genatlas (Paris)AGR2
WikiGenes10551
SOURCE (Princeton)AGR2
Genetics Home Reference (NIH)AGR2
Genomic and cartography
GoldenPath hg38 (UCSC)AGR2  -     chr7:16792640-16805114 -  7p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGR2  -     7p21.1   [Description]    (hg19-Feb_2009)
EnsemblAGR2 - 7p21.1 [CytoView hg19]  AGR2 - 7p21.1 [CytoView hg38]
Mapping of homologs : NCBIAGR2 [Mapview hg19]  AGR2 [Mapview hg38]
OMIM606358   
Gene and transcription
Genbank (Entrez)AF007791 AF038451 AF038452 AF087879 AF088867
RefSeq transcript (Entrez)NM_006408
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGR2
Cluster EST : UnigeneHs.530009 [ NCBI ]
CGAP (NCI)Hs.530009
Alternative Splicing GalleryENSG00000106541
Gene ExpressionAGR2 [ NCBI-GEO ]   AGR2 [ EBI - ARRAY_EXPRESS ]   AGR2 [ SEEK ]   AGR2 [ MEM ]
Gene Expression Viewer (FireBrowse)AGR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10551
GTEX Portal (Tissue expression)AGR2
Human Protein AtlasENSG00000106541-AGR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95994   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95994  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95994
Splice isoforms : SwissVarO95994
PhosPhoSitePlusO95994
Domains : Interpro (EBI)Thioredoxin-like_fold   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)AGR2
DMDM Disease mutations10551
Blocks (Seattle)AGR2
PDB (SRS)2LNS    2LNT   
PDB (PDBSum)2LNS    2LNT   
PDB (IMB)2LNS    2LNT   
PDB (RSDB)2LNS    2LNT   
Structural Biology KnowledgeBase2LNS    2LNT   
SCOP (Structural Classification of Proteins)2LNS    2LNT   
CATH (Classification of proteins structures)2LNS    2LNT   
SuperfamilyO95994
Human Protein Atlas [tissue]ENSG00000106541-AGR2 [tissue]
Peptide AtlasO95994
HPRD05896
IPIIPI00942032   IPI00007427   IPI00893607   IPI00893733   IPI00952571   
Protein Interaction databases
DIP (DOE-UCLA)O95994
IntAct (EBI)O95994
FunCoupENSG00000106541
BioGRIDAGR2
STRING (EMBL)AGR2
ZODIACAGR2
Ontologies - Pathways
QuickGOO95994
Ontology : AmiGOdystroglycan binding  epidermal growth factor receptor binding  protein binding  extracellular space  mitochondrion  endoplasmic reticulum  endoplasmic reticulum  positive regulation of gene expression  positive regulation of cell-substrate adhesion  cell differentiation  response to endoplasmic reticulum stress  protein homodimerization activity  positive regulation of epidermal growth factor receptor signaling pathway  digestive tract morphogenesis  positive regulation of developmental growth  lung goblet cell differentiation  negative regulation of cell death  mucus secretion  positive regulation of establishment of protein localization to plasma membrane  positive regulation of IRE1-mediated unfolded protein response  positive regulation of PERK-mediated unfolded protein response  
Ontology : EGO-EBIdystroglycan binding  epidermal growth factor receptor binding  protein binding  extracellular space  mitochondrion  endoplasmic reticulum  endoplasmic reticulum  positive regulation of gene expression  positive regulation of cell-substrate adhesion  cell differentiation  response to endoplasmic reticulum stress  protein homodimerization activity  positive regulation of epidermal growth factor receptor signaling pathway  digestive tract morphogenesis  positive regulation of developmental growth  lung goblet cell differentiation  negative regulation of cell death  mucus secretion  positive regulation of establishment of protein localization to plasma membrane  positive regulation of IRE1-mediated unfolded protein response  positive regulation of PERK-mediated unfolded protein response  
NDEx NetworkAGR2
Atlas of Cancer Signalling NetworkAGR2
Wikipedia pathwaysAGR2
Orthology - Evolution
OrthoDB10551
GeneTree (enSembl)ENSG00000106541
Phylogenetic Trees/Animal Genes : TreeFamAGR2
HOVERGENO95994
HOGENOMO95994
Homologs : HomoloGeneAGR2
Homology/Alignments : Family Browser (UCSC)AGR2
Gene fusions - Rearrangements
Tumor Fusion PortalAGR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGR2
dbVarAGR2
ClinVarAGR2
1000_GenomesAGR2 
Exome Variant ServerAGR2
ExAC (Exome Aggregation Consortium)ENSG00000106541
GNOMAD BrowserENSG00000106541
Genetic variants : HAPMAP10551
Genomic Variants (DGV)AGR2 [DGVbeta]
DECIPHERAGR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGR2 
Mutations
ICGC Data PortalAGR2 
TCGA Data PortalAGR2 
Broad Tumor PortalAGR2
OASIS PortalAGR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AGR2
DgiDB (Drug Gene Interaction Database)AGR2
DoCM (Curated mutations)AGR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGR2 (select a term)
intoGenAGR2
Cancer3DAGR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606358   
Orphanet
DisGeNETAGR2
MedgenAGR2
Genetic Testing Registry AGR2
NextProtO95994 [Medical]
TSGene10551
GENETestsAGR2
Target ValidationAGR2
Huge Navigator AGR2 [HugePedia]
snp3D : Map Gene to Disease10551
BioCentury BCIQAGR2
ClinGenAGR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10551
Chemical/Pharm GKB GenePA24625
Clinical trialAGR2
Miscellaneous
canSAR (ICR)AGR2 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGR2
EVEXAGR2
GoPubMedAGR2
iHOPAGR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:27 CET 2017

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