Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AGTR1 (angiotensin II receptor type 1)

Identity

Alias_namesAGTR1B
angiotensin receptor 1B
Alias_symbol (synonym)AT1
AT2R1
AGTR1A
AT2R1A
HAT1R
AG2S
AT2R1B
AT1B
HGNC (Hugo) AGTR1
LocusID (NCBI) 185
Atlas_Id 46595
Location 3q24  [Link to chromosome band 3q24]
Location_base_pair Starts at 148415658 and ends at 148460790 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGTR1   336
Cards
Entrez_Gene (NCBI)AGTR1  185  angiotensin II receptor type 1
AliasesAG2S; AGTR1B; AT1; AT1AR; 
AT1B; AT1BR; AT1R; AT2R1; HAT1R
GeneCards (Weizmann)AGTR1
Ensembl hg19 (Hinxton)ENSG00000144891 [Gene_View]  chr3:148415658-148460790 [Contig_View]  AGTR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000144891 [Gene_View]  chr3:148415658-148460790 [Contig_View]  AGTR1 [Vega]
ICGC DataPortalENSG00000144891
TCGA cBioPortalAGTR1
AceView (NCBI)AGTR1
Genatlas (Paris)AGTR1
WikiGenes185
SOURCE (Princeton)AGTR1
Genetics Home Reference (NIH)AGTR1
Genomic and cartography
GoldenPath hg19 (UCSC)AGTR1  -     chr3:148415658-148460790 +  3q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AGTR1  -     3q24   [Description]    (hg38-Dec_2013)
EnsemblAGTR1 - 3q24 [CytoView hg19]  AGTR1 - 3q24 [CytoView hg38]
Mapping of homologs : NCBIAGTR1 [Mapview hg19]  AGTR1 [Mapview hg38]
OMIM106165   145500   267430   
Gene and transcription
Genbank (Entrez)AI016286 AI240900 AK291541 AV651073 BC022447
RefSeq transcript (Entrez)NM_000685 NM_004835 NM_009585 NM_031850 NM_032049
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_008468 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)AGTR1
Cluster EST : UnigeneHs.744837 [ NCBI ]
CGAP (NCI)Hs.744837
Alternative Splicing GalleryENSG00000144891
Gene ExpressionAGTR1 [ NCBI-GEO ]   AGTR1 [ EBI - ARRAY_EXPRESS ]   AGTR1 [ SEEK ]   AGTR1 [ MEM ]
Gene Expression Viewer (FireBrowse)AGTR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)185
GTEX Portal (Tissue expression)AGTR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30556   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30556  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30556
Splice isoforms : SwissVarP30556
PhosPhoSitePlusP30556
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ATII_AT1_rcpt    ATII_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)AGTR1
DMDM Disease mutations185
Blocks (Seattle)AGTR1
PDB (SRS)1ZV0    4YAY    4ZUD   
PDB (PDBSum)1ZV0    4YAY    4ZUD   
PDB (IMB)1ZV0    4YAY    4ZUD   
PDB (RSDB)1ZV0    4YAY    4ZUD   
Structural Biology KnowledgeBase1ZV0    4YAY    4ZUD   
SCOP (Structural Classification of Proteins)1ZV0    4YAY    4ZUD   
CATH (Classification of proteins structures)1ZV0    4YAY    4ZUD   
SuperfamilyP30556
Human Protein AtlasENSG00000144891
Peptide AtlasP30556
HPRD00107
IPIIPI00797565   
Protein Interaction databases
DIP (DOE-UCLA)P30556
IntAct (EBI)P30556
FunCoupENSG00000144891
BioGRIDAGTR1
STRING (EMBL)AGTR1
ZODIACAGTR1
Ontologies - Pathways
QuickGOP30556
Ontology : AmiGOregulation of cell growth  angiotensin type I receptor activity  angiotensin type I receptor activity  kidney development  renin-angiotensin regulation of aldosterone production  regulation of blood vessel size by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  angiotensin type II receptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  integral component of membrane  regulation of vasoconstriction  regulation of vasoconstriction  regulation of vasoconstriction  calcium-mediated signaling  bradykinin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of phospholipase A2 activity  positive regulation of NAD(P)H oxidase activity  low-density lipoprotein particle remodeling  regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  regulation of vasodilation  protein heterodimerization activity  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  cell chemotaxis  phospholipase C-activating angiotensin-activated signaling pathway  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIregulation of cell growth  angiotensin type I receptor activity  angiotensin type I receptor activity  kidney development  renin-angiotensin regulation of aldosterone production  regulation of blood vessel size by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  angiotensin type II receptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  integral component of membrane  regulation of vasoconstriction  regulation of vasoconstriction  regulation of vasoconstriction  calcium-mediated signaling  bradykinin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of phospholipase A2 activity  positive regulation of NAD(P)H oxidase activity  low-density lipoprotein particle remodeling  regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  regulation of vasodilation  protein heterodimerization activity  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  cell chemotaxis  phospholipase C-activating angiotensin-activated signaling pathway  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTAAngiotensin-converting enzyme 2 regulates heart function [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Renin-angiotensin system   
NDEx NetworkAGTR1
Atlas of Cancer Signalling NetworkAGTR1
Wikipedia pathwaysAGTR1
Orthology - Evolution
OrthoDB185
GeneTree (enSembl)ENSG00000144891
Phylogenetic Trees/Animal Genes : TreeFamAGTR1
HOVERGENP30556
HOGENOMP30556
Homologs : HomoloGeneAGTR1
Homology/Alignments : Family Browser (UCSC)AGTR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGTR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGTR1
dbVarAGTR1
ClinVarAGTR1
1000_GenomesAGTR1 
Exome Variant ServerAGTR1
ExAC (Exome Aggregation Consortium)AGTR1 (select the gene name)
Genetic variants : HAPMAP185
Genomic Variants (DGV)AGTR1 [DGVbeta]
DECIPHER (Syndromes)3:148415658-148460790  ENSG00000144891
CONAN: Copy Number AnalysisAGTR1 
Mutations
ICGC Data PortalAGTR1 
TCGA Data PortalAGTR1 
Broad Tumor PortalAGTR1
OASIS PortalAGTR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGTR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGTR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AGTR1
DgiDB (Drug Gene Interaction Database)AGTR1
DoCM (Curated mutations)AGTR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGTR1 (select a term)
intoGenAGTR1
Cancer3DAGTR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM106165    145500    267430   
Orphanet12920   
MedgenAGTR1
Genetic Testing Registry AGTR1
NextProtP30556 [Medical]
TSGene185
GENETestsAGTR1
Huge Navigator AGTR1 [HugePedia]
snp3D : Map Gene to Disease185
BioCentury BCIQAGTR1
ClinGenAGTR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD185
Chemical/Pharm GKB GenePA43
Clinical trialAGTR1
Miscellaneous
canSAR (ICR)AGTR1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGTR1
EVEXAGTR1
GoPubMedAGTR1
iHOPAGTR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:30:29 CET 2016

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