AGTR1 (angiotensin II receptor type 1)

2007-02-01  

Identity

HGNC
AGTR1
LOCATION
3q24
LOCUSID
185
ALIAS
AG2S,AGTR1B,AT1,AT1AR,AT1B,AT1BR,AT1R,AT2R1,HAT1R

Other Information

Locus ID:

NCBI: 185
MIM: 106165
HGNC: 336
Ensembl: ENSG00000144891

Variants:

dbSNP: 185
ClinVar: 185
TCGA: ENSG00000144891
COSMIC: AGTR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144891ENST00000349243P30556
ENSG00000144891ENST00000349243Q53YY0
ENSG00000144891ENST00000402260A0A0A0MSE3
ENSG00000144891ENST00000404754P30556
ENSG00000144891ENST00000404754Q53YY0
ENSG00000144891ENST00000418473D3DNG8
ENSG00000144891ENST00000461609P30556
ENSG00000144891ENST00000461609Q53YY0
ENSG00000144891ENST00000474935P30556
ENSG00000144891ENST00000474935Q53YY0
ENSG00000144891ENST00000475347P30556
ENSG00000144891ENST00000475347Q53YY0
ENSG00000144891ENST00000497524P30556
ENSG00000144891ENST00000497524Q53YY0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Renin-angiotensin systemKEGGko04614
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Renin-angiotensin systemKEGGhsa04614
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA146096020nitrendipineChemicalClinicalAnnotationassociatedPD8952600
PA164712308Ace Inhibitors, PlainChemicalClinicalAnnotationassociatedPD18347611, 23407050
PA164713347Thiazides, plainChemicalClinicalAnnotationassociatedPD19247266
PA166109554angiotensin IIChemicalClinicalAnnotationassociatedPD10594793
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD20712529, 23407050
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotationassociatedPD19286758
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD18594050
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD18347611, 8952600
PA444797Liver CirrhosisDiseaseClinicalAnnotationassociatedPD15743363
PA448500atorvastatinChemicalClinicalAnnotationassociatedPK
PA448765candesartanChemicalClinicalAnnotationassociatedPD18594050
PA448780captoprilChemicalClinicalAnnotationassociatedPD19286758
PA450268losartanChemicalClinicalAnnotation, PathwayassociatedPD10594793, 15743363, 20436376
PA450877perindoprilChemicalClinicalAnnotationassociatedPD20712529, 8952600

References

Pubmed IDYearTitleCitations
120452552002Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.344
176683902007Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.113
157184972005Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.100
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
194616482009Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis.64
120319552002Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors.61
182027202008Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation.58
195873572009A systematic meta-analysis of genetic association studies for diabetic retinopathy.57
184649322008Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.51

Citation

Dessen P

AGTR1 (angiotensin II receptor type 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46595/agtr1