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AGTR1 (angiotensin II receptor, type 1)

Identity

Other namesAG2S
AGTR1B
AT1
AT1AR
AT1B
AT1BR
AT1R
AT2R1
HAT1R
HGNC (Hugo) AGTR1
LocusID (NCBI) 185
Location 3q24
Location_base_pair Starts at 148415658 and ends at 148460790 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AGTR1   336
Cards
Entrez_Gene (NCBI)AGTR1  185  angiotensin II receptor, type 1
GeneCards (Weizmann)AGTR1
Ensembl (Hinxton)ENSG00000144891 [Gene_View]  chr3:148415658-148460790 [Contig_View]  AGTR1 [Vega]
ICGC DataPortalENSG00000144891
cBioPortalAGTR1
AceView (NCBI)AGTR1
Genatlas (Paris)AGTR1
WikiGenes185
SOURCE (Princeton)NM_000685 NM_004835 NM_009585 NM_031850 NM_032049
Genomic and cartography
GoldenPath (UCSC)AGTR1  -  3q24   chr3:148415658-148460790 +  3q24   [Description]    (hg19-Feb_2009)
EnsemblAGTR1 - 3q24 [CytoView]
Mapping of homologs : NCBIAGTR1 [Mapview]
OMIM106165   145500   267430   
Gene and transcription
Genbank (Entrez)AI016286 AI240900 AK291541 AV651073 BC022447
RefSeq transcript (Entrez)NM_000685 NM_004835 NM_009585 NM_031850 NM_032049
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_008468 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)AGTR1
Cluster EST : UnigeneHs.744837 [ NCBI ]
CGAP (NCI)Hs.744837
Alternative Splicing : Fast-db (Paris)GSHG0021236
Alternative Splicing GalleryENSG00000144891
Gene ExpressionAGTR1 [ NCBI-GEO ]     AGTR1 [ SEEK ]   AGTR1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30556 (Uniprot)
NextProtP30556  [Medical]
With graphics : InterProP30556
Splice isoforms : SwissVarP30556 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ATII_AT1_rcpt [organisation]   ATII_rcpt [organisation]   GPCR_Rhodpsn [organisation]   GPCR_Rhodpsn_7TM [organisation]  
Related proteins : CluSTrP30556
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM Disease mutations185
Blocks (Seattle)P30556
PDB (SRS)1ZV0   
PDB (PDBSum)1ZV0   
PDB (IMB)1ZV0   
PDB (RSDB)1ZV0   
Human Protein AtlasENSG00000144891 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP30556
HPRD00107
IPIIPI00797565   
Protein Interaction databases
DIP (DOE-UCLA)P30556
IntAct (EBI)P30556
FunCoupENSG00000144891
BioGRIDAGTR1
InParanoidP30556
Interologous Interaction database P30556
IntegromeDBAGTR1
STRING (EMBL)AGTR1
Ontologies - Pathways
Ontology : AmiGOregulation of cell growth  angiotensin type I receptor activity  angiotensin type I receptor activity  kidney development  renin-angiotensin regulation of aldosterone production  regulation of blood vessel size by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  angiotensin type II receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  integral component of membrane  regulation of vasoconstriction  regulation of vasoconstriction  regulation of vasoconstriction  calcium-mediated signaling  bradykinin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of phospholipase A2 activity  positive regulation of NAD(P)H oxidase activity  low-density lipoprotein particle remodeling  regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  regulation of vasodilation  protein heterodimerization activity  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  cell chemotaxis  phospholipase C-activating angiotensin-activated signaling pathway  phospholipase C-activating angiotensin-activated signaling pathway  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIregulation of cell growth  angiotensin type I receptor activity  angiotensin type I receptor activity  kidney development  renin-angiotensin regulation of aldosterone production  regulation of blood vessel size by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  angiotensin type II receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Rho protein signal transduction  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  integral component of membrane  regulation of vasoconstriction  regulation of vasoconstriction  regulation of vasoconstriction  calcium-mediated signaling  bradykinin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of phospholipase A2 activity  positive regulation of NAD(P)H oxidase activity  low-density lipoprotein particle remodeling  regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  regulation of vasodilation  protein heterodimerization activity  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  cell chemotaxis  phospholipase C-activating angiotensin-activated signaling pathway  phospholipase C-activating angiotensin-activated signaling pathway  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTAAngiotensin-converting enzyme 2 regulates heart function [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Renin-angiotensin system   
Protein Interaction DatabaseAGTR1
Wikipedia pathwaysAGTR1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)AGTR1
snp3D : Map Gene to Disease185
SNP (GeneSNP Utah)AGTR1
SNP : HGBaseAGTR1
Genetic variants : HAPMAPAGTR1
Exome VariantAGTR1
1000_GenomesAGTR1 
ICGC programENSG00000144891 
Somatic Mutations in Cancer : COSMICAGTR1 
CONAN: Copy Number AnalysisAGTR1 
Mutations and Diseases : HGMDAGTR1
Genomic VariantsAGTR1  AGTR1 [DGVbeta]
dbVarAGTR1
ClinVarAGTR1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM106165    145500    267430   
MedgenAGTR1
GENETestsAGTR1
Disease Genetic AssociationAGTR1
Huge Navigator AGTR1 [HugePedia]  AGTR1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneAGTR1
Homology/Alignments : Family Browser (UCSC)AGTR1
Phylogenetic Trees/Animal Genes : TreeFamAGTR1
Chemical/Protein Interactions : CTD185
Chemical/Pharm GKB GenePA43
Clinical trialAGTR1
Cancer Resource (Charite)ENSG00000144891
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineAGTR1
iHOPAGTR1
OncoSearchAGTR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:23:22 CEST 2014

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