Atlas of Genetics and Cytogenetics in Oncology and Haematology

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AGTR2 (angiotensin II receptor type 2)

Identity

Alias (NCBI)AT2
ATGR2
MRX88
HGNC (Hugo) AGTR2
HGNC Alias symbAT2
MRX88
HGNC Previous nameangiotensin receptor 2
LocusID (NCBI) 186
Atlas_Id 46183
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 116170744 and ends at 116174974 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AGTR2   338
Cards
Entrez_Gene (NCBI)AGTR2  186  angiotensin II receptor type 2
AliasesAT2; ATGR2; MRX88
GeneCards (Weizmann)AGTR2
Ensembl hg19 (Hinxton)ENSG00000180772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180772 [Gene_View]  ENSG00000180772 [Sequence]  chrX:116170744-116174974 [Contig_View]  AGTR2 [Vega]
ICGC DataPortalENSG00000180772
TCGA cBioPortalAGTR2
AceView (NCBI)AGTR2
Genatlas (Paris)AGTR2
WikiGenes186
SOURCE (Princeton)AGTR2
Genetics Home Reference (NIH)AGTR2
Genomic and cartography
GoldenPath hg38 (UCSC)AGTR2  -     chrX:116170744-116174974 +  Xq23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGTR2  -     Xq23   [Description]    (hg19-Feb_2009)
GoldenPathAGTR2 - Xq23 [CytoView hg19]  AGTR2 - Xq23 [CytoView hg38]
ImmunoBaseENSG00000180772
genome Data Viewer NCBIAGTR2 [Mapview hg19]  
OMIM300034   
Gene and transcription
Genbank (Entrez)AI911273 AK313927 BC095504 CR541969 CR738498
RefSeq transcript (Entrez)NM_000686
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGTR2
Alternative Splicing GalleryENSG00000180772
Gene ExpressionAGTR2 [ NCBI-GEO ]   AGTR2 [ EBI - ARRAY_EXPRESS ]   AGTR2 [ SEEK ]   AGTR2 [ MEM ]
Gene Expression Viewer (FireBrowse)AGTR2 [ Firebrowse - Broad ]
GenevisibleExpression of AGTR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)186
GTEX Portal (Tissue expression)AGTR2
Human Protein AtlasENSG00000180772-AGTR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50052   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50052  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50052
Splice isoforms : SwissVarP50052
PhosPhoSitePlusP50052
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ATII_AT2_rcpt    ATII_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)AGTR2
DMDM Disease mutations186
Blocks (Seattle)AGTR2
PDB (RSDB)5UNF    5UNG    5UNH    6JOD   
PDB Europe5UNF    5UNG    5UNH    6JOD   
PDB (PDBSum)5UNF    5UNG    5UNH    6JOD   
PDB (IMB)5UNF    5UNG    5UNH    6JOD   
Structural Biology KnowledgeBase5UNF    5UNG    5UNH    6JOD   
SCOP (Structural Classification of Proteins)5UNF    5UNG    5UNH    6JOD   
CATH (Classification of proteins structures)5UNF    5UNG    5UNH    6JOD   
SuperfamilyP50052
Human Protein Atlas [tissue]ENSG00000180772-AGTR2 [tissue]
Peptide AtlasP50052
HPRD02071
IPIIPI00029486   
Protein Interaction databases
DIP (DOE-UCLA)P50052
IntAct (EBI)P50052
FunCoupENSG00000180772
BioGRIDAGTR2
STRING (EMBL)AGTR2
ZODIACAGTR2
Ontologies - Pathways
QuickGOP50052
Ontology : AmiGOblood vessel remodeling  regulation of systemic arterial blood pressure by circulatory renin-angiotensin  renin-angiotensin regulation of aldosterone production  angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  brain renin-angiotensin system  G protein-coupled receptor activity  angiotensin type II receptor activity  angiotensin type II receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular sodium ion homeostasis  inflammatory response  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  nitric oxide mediated signal transduction  nitric oxide mediated signal transduction  brain development  transcription factor binding  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of heart rate  negative regulation of norepinephrine secretion  cerebellar cortex development  negative regulation of cell growth  negative regulation of icosanoid secretion  positive regulation of phosphoprotein phosphatase activity  intracellular signal transduction  regulation of metanephros size  exploration behavior  positive regulation of renal sodium excretion  aldosterone secretion  angiotensin-activated signaling pathway  regulation of protein import into nucleus  vasodilation  dopamine biosynthetic process  negative regulation of blood vessel endothelial cell migration  positive regulation of nitric oxide biosynthetic process  positive regulation of transcription, DNA-templated  receptor antagonist activity  negative regulation of fibroblast proliferation  perinuclear region of cytoplasm  positive regulation of cytokine secretion  positive regulation of nitric-oxide synthase activity  negative regulation of neurotrophin TRK receptor signaling pathway  cell growth involved in cardiac muscle cell development  cellular response to dexamethasone stimulus  positive regulation of metanephric glomerulus development  positive regulation of branching involved in ureteric bud morphogenesis  positive regulation of blood vessel diameter  negative regulation of signaling receptor activity  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIblood vessel remodeling  regulation of systemic arterial blood pressure by circulatory renin-angiotensin  renin-angiotensin regulation of aldosterone production  angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  brain renin-angiotensin system  G protein-coupled receptor activity  angiotensin type II receptor activity  angiotensin type II receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular sodium ion homeostasis  inflammatory response  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  nitric oxide mediated signal transduction  nitric oxide mediated signal transduction  brain development  transcription factor binding  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of heart rate  negative regulation of norepinephrine secretion  cerebellar cortex development  negative regulation of cell growth  negative regulation of icosanoid secretion  positive regulation of phosphoprotein phosphatase activity  intracellular signal transduction  regulation of metanephros size  exploration behavior  positive regulation of renal sodium excretion  aldosterone secretion  angiotensin-activated signaling pathway  regulation of protein import into nucleus  vasodilation  dopamine biosynthetic process  negative regulation of blood vessel endothelial cell migration  positive regulation of nitric oxide biosynthetic process  positive regulation of transcription, DNA-templated  receptor antagonist activity  negative regulation of fibroblast proliferation  perinuclear region of cytoplasm  positive regulation of cytokine secretion  positive regulation of nitric-oxide synthase activity  negative regulation of neurotrophin TRK receptor signaling pathway  cell growth involved in cardiac muscle cell development  cellular response to dexamethasone stimulus  positive regulation of metanephric glomerulus development  positive regulation of branching involved in ureteric bud morphogenesis  positive regulation of blood vessel diameter  negative regulation of signaling receptor activity  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGNeuroactive ligand-receptor interaction    Adrenergic signaling in cardiomyocytes    Renin-angiotensin system   
NDEx NetworkAGTR2
Atlas of Cancer Signalling NetworkAGTR2
Wikipedia pathwaysAGTR2
Orthology - Evolution
OrthoDB186
GeneTree (enSembl)ENSG00000180772
Phylogenetic Trees/Animal Genes : TreeFamAGTR2
HOGENOMP50052
Homologs : HomoloGeneAGTR2
Homology/Alignments : Family Browser (UCSC)AGTR2
Gene fusions - Rearrangements
Fusion : QuiverAGTR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGTR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGTR2
dbVarAGTR2
ClinVarAGTR2
MonarchAGTR2
1000_GenomesAGTR2 
Exome Variant ServerAGTR2
GNOMAD BrowserENSG00000180772
Varsome BrowserAGTR2
Genetic variants : HAPMAP186
Genomic Variants (DGV)AGTR2 [DGVbeta]
DECIPHERAGTR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGTR2 
Mutations
ICGC Data PortalAGTR2 
TCGA Data PortalAGTR2 
Broad Tumor PortalAGTR2
OASIS PortalAGTR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGTR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAGTR2
Mutations and Diseases : HGMDAGTR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch AGTR2
DgiDB (Drug Gene Interaction Database)AGTR2
DoCM (Curated mutations)AGTR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGTR2 (select a term)
intoGenAGTR2
Cancer3DAGTR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300034   
Orphanet3256   
DisGeNETAGTR2
MedgenAGTR2
Genetic Testing Registry AGTR2
NextProtP50052 [Medical]
TSGene186
GENETestsAGTR2
Target ValidationAGTR2
Huge Navigator AGTR2 [HugePedia]
snp3D : Map Gene to Disease186
BioCentury BCIQAGTR2
ClinGenAGTR2 (curated)
Clinical trials, drugs, therapy
Protein Interactions : CTD186
Pharm GKB GenePA44
Pharm GKB PathwaysPA165110622   PA2023   
Clinical trialAGTR2
Miscellaneous
canSAR (ICR)AGTR2 (select the gene name)
HarmonizomeAGTR2
DataMed IndexAGTR2
Probes
Litterature
PubMed230 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGTR2
EVEXAGTR2
GoPubMedAGTR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:00:53 CEST 2020
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