AGTRAP (angiotensin II receptor associated protein)

2012-11-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
ATRAP
FUSION GENES

Other Information

Locus ID:

NCBI: 57085
MIM: 608729
HGNC: 13539
Ensembl: ENSG00000177674

Variants:

dbSNP: 57085
ClinVar: 57085
TCGA: ENSG00000177674
COSMIC: AGTRAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177674ENST00000314340Q6RW13
ENSG00000177674ENST00000376627X6R9H3
ENSG00000177674ENST00000376629Q6RW13
ENSG00000177674ENST00000376637Q6RW13
ENSG00000177674ENST00000400895Q6RW13
ENSG00000177674ENST00000452018Q6RW13
ENSG00000177674ENST00000476512D6RB40
ENSG00000177674ENST00000510878D6RBK6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
145592502003Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane.20
156682452005Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.16
214230012011Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.13
239026392013Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
149853642004A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells.10
217289942011The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).10
198057402009Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydration.9
117331892002Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap).7

Citation

Dessen P

AGTRAP (angiotensin II receptor associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52968/agtrap