Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AGXT (alanine-glyoxylate aminotransferase)

Identity

Alias_namesSPAT
Alias_symbol (synonym)AGXT1
PH1
AGT
SPT
AGT1
Other aliasTLH6
HGNC (Hugo) AGXT
LocusID (NCBI) 189
Atlas_Id 60211
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 240868745 and ends at 240879119 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGXT   341
Cards
Entrez_Gene (NCBI)AGXT  189  alanine-glyoxylate aminotransferase
AliasesAGT; AGT1; AGXT1; PH1; 
SPAT; SPT; TLH6
GeneCards (Weizmann)AGXT
Ensembl hg19 (Hinxton)ENSG00000172482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172482 [Gene_View]  chr2:240868745-240879119 [Contig_View]  AGXT [Vega]
ICGC DataPortalENSG00000172482
TCGA cBioPortalAGXT
AceView (NCBI)AGXT
Genatlas (Paris)AGXT
WikiGenes189
SOURCE (Princeton)AGXT
Genetics Home Reference (NIH)AGXT
Genomic and cartography
GoldenPath hg38 (UCSC)AGXT  -     chr2:240868745-240879119 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGXT  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblAGXT - 2q37.3 [CytoView hg19]  AGXT - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIAGXT [Mapview hg19]  AGXT [Mapview hg38]
OMIM259900   604285   
Gene and transcription
Genbank (Entrez)AA857309 AB292648 AF191687 AF348451 AK292754
RefSeq transcript (Entrez)NM_000030
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGXT
Cluster EST : UnigeneHs.144567 [ NCBI ]
CGAP (NCI)Hs.144567
Alternative Splicing GalleryENSG00000172482
Gene ExpressionAGXT [ NCBI-GEO ]   AGXT [ EBI - ARRAY_EXPRESS ]   AGXT [ SEEK ]   AGXT [ MEM ]
Gene Expression Viewer (FireBrowse)AGXT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)189
GTEX Portal (Tissue expression)AGXT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21549   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21549  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21549
Splice isoforms : SwissVarP21549
Catalytic activity : Enzyme2.6.1.51 [ Enzyme-Expasy ]   2.6.1.512.6.1.51 [ IntEnz-EBI ]   2.6.1.51 [ BRENDA ]   2.6.1.51 [ KEGG ]   
PhosPhoSitePlusP21549
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_5 (PS00595)   
Domains : Interpro (EBI)Aminotrans_V_dom    Aminotrans_V_PyrdxlP_BS    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2    SP_NH2Trfase/AEP_transaminase   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)AGXT
DMDM Disease mutations189
Blocks (Seattle)AGXT
PDB (SRS)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
PDB (PDBSum)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
PDB (IMB)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
PDB (RSDB)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
Structural Biology KnowledgeBase1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
SCOP (Structural Classification of Proteins)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
CATH (Classification of proteins structures)1H0C    1J04    2YOB    3R9A    4CBR    4CBS    4I8A    4KXK    4KYO    5F9S    5HHY   
SuperfamilyP21549
Human Protein AtlasENSG00000172482
Peptide AtlasP21549
HPRD05048
IPIIPI00009367   IPI00384286   
Protein Interaction databases
DIP (DOE-UCLA)P21549
IntAct (EBI)P21549
FunCoupENSG00000172482
BioGRIDAGXT
STRING (EMBL)AGXT
ZODIACAGXT
Ontologies - Pathways
QuickGOP21549
Ontology : AmiGOserine-pyruvate transaminase activity  receptor binding  protein binding  mitochondrial matrix  peroxisome  peroxisomal matrix  peroxisomal matrix  Notch signaling pathway  alanine-glyoxylate transaminase activity  alanine-glyoxylate transaminase activity  transaminase activity  glyoxylate catabolic process  amino acid binding  glycine biosynthetic process, by transamination of glyoxylate  L-cysteine catabolic process  pyridoxal phosphate binding  pyridoxal phosphate binding  protein homodimerization activity  L-alanine catabolic process  pyruvate biosynthetic process  intracellular membrane-bounded organelle  protein self-association  glyoxylate metabolic process  glyoxylate metabolic process  oxalic acid secretion  response to glucocorticoid  response to cAMP  
Ontology : EGO-EBIserine-pyruvate transaminase activity  receptor binding  protein binding  mitochondrial matrix  peroxisome  peroxisomal matrix  peroxisomal matrix  Notch signaling pathway  alanine-glyoxylate transaminase activity  alanine-glyoxylate transaminase activity  transaminase activity  glyoxylate catabolic process  amino acid binding  glycine biosynthetic process, by transamination of glyoxylate  L-cysteine catabolic process  pyridoxal phosphate binding  pyridoxal phosphate binding  protein homodimerization activity  L-alanine catabolic process  pyruvate biosynthetic process  intracellular membrane-bounded organelle  protein self-association  glyoxylate metabolic process  glyoxylate metabolic process  oxalic acid secretion  response to glucocorticoid  response to cAMP  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Glycine, serine and threonine metabolism    Glyoxylate and dicarboxylate metabolism    Peroxisome   
NDEx NetworkAGXT
Atlas of Cancer Signalling NetworkAGXT
Wikipedia pathwaysAGXT
Orthology - Evolution
OrthoDB189
GeneTree (enSembl)ENSG00000172482
Phylogenetic Trees/Animal Genes : TreeFamAGXT
HOVERGENP21549
HOGENOMP21549
Homologs : HomoloGeneAGXT
Homology/Alignments : Family Browser (UCSC)AGXT
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGXT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGXT
dbVarAGXT
ClinVarAGXT
1000_GenomesAGXT 
Exome Variant ServerAGXT
ExAC (Exome Aggregation Consortium)AGXT (select the gene name)
Genetic variants : HAPMAP189
Genomic Variants (DGV)AGXT [DGVbeta]
DECIPHERAGXT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGXT 
Mutations
ICGC Data PortalAGXT 
TCGA Data PortalAGXT 
Broad Tumor PortalAGXT
OASIS PortalAGXT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGXT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGXT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AGXT
DgiDB (Drug Gene Interaction Database)AGXT
DoCM (Curated mutations)AGXT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGXT (select a term)
intoGenAGXT
Cancer3DAGXT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM259900    604285   
Orphanet12431   
MedgenAGXT
Genetic Testing Registry AGXT
NextProtP21549 [Medical]
TSGene189
GENETestsAGXT
Target ValidationAGXT
Huge Navigator AGXT [HugePedia]
snp3D : Map Gene to Disease189
BioCentury BCIQAGXT
ClinGenAGXT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD189
Chemical/Pharm GKB GenePA24633
Clinical trialAGXT
Miscellaneous
canSAR (ICR)AGXT (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGXT
EVEXAGXT
GoPubMedAGXT
iHOPAGXT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:09:02 CEST 2017

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