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AGXT2 (alanine--glyoxylate aminotransferase 2)

Identity

Alias_namesalanine-glyoxylate aminotransferase 2
Alias_symbol (synonym)AGT2
Other aliasDAIBAT
HGNC (Hugo) AGXT2
LocusID (NCBI) 64902
Atlas_Id 60212
Location 5p13.2  [Link to chromosome band 5p13]
Location_base_pair Starts at 34998101 and ends at 35048135 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERPINA1 (14q32.13) / AGXT2 (5p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGXT2   14412
Cards
Entrez_Gene (NCBI)AGXT2  64902  alanine--glyoxylate aminotransferase 2
AliasesAGT2; DAIBAT
GeneCards (Weizmann)AGXT2
Ensembl hg19 (Hinxton)ENSG00000113492 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113492 [Gene_View]  chr5:34998101-35048135 [Contig_View]  AGXT2 [Vega]
ICGC DataPortalENSG00000113492
TCGA cBioPortalAGXT2
AceView (NCBI)AGXT2
Genatlas (Paris)AGXT2
WikiGenes64902
SOURCE (Princeton)AGXT2
Genetics Home Reference (NIH)AGXT2
Genomic and cartography
GoldenPath hg38 (UCSC)AGXT2  -     chr5:34998101-35048135 -  5p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGXT2  -     5p13.2   [Description]    (hg19-Feb_2009)
EnsemblAGXT2 - 5p13.2 [CytoView hg19]  AGXT2 - 5p13.2 [CytoView hg38]
Mapping of homologs : NCBIAGXT2 [Mapview hg19]  AGXT2 [Mapview hg38]
OMIM612471   
Gene and transcription
Genbank (Entrez)AB193309 AJ292204 AK055732 AK055757 AK223128
RefSeq transcript (Entrez)NM_001306173 NM_031900
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGXT2
Cluster EST : UnigeneHs.34494 [ NCBI ]
CGAP (NCI)Hs.34494
Alternative Splicing GalleryENSO0p000113492
Gene ExpressionAGXT2 [ NCBI-GEO ]   AGXT2 [ EBI - ARRAY_EXPRESS ]   AGXT2 [ SEEK ]   AGXT2 [ MEM ]
Gene Expression Viewer (FireBrowse)AGXT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64902
GTEX Portal (Tissue expression)AGXT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYV1
Splice isoforms : SwissVarQ9BYV1
Catalytic activity : Enzyme2.6.1.44 [ Enzyme-Expasy ]   2.6.1.442.6.1.44 [ IntEnz-EBI ]   2.6.1.44 [ BRENDA ]   2.6.1.44 [ KEGG ]   
PhosPhoSitePlusQ9BYV1
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_3 (PS00600)   
Domains : Interpro (EBI)Aminotrans_3    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_3 (PF00202)   
Domain families : Pfam (NCBI)pfam00202   
Conserved Domain (NCBI)AGXT2
DMDM Disease mutations64902
Blocks (Seattle)AGXT2
SuperfamilyQ9BYV1
Human Protein AtlasENSG00000113492
Peptide AtlasQ9BYV1
HPRD10638
IPIIPI00011075   IPI00922302   IPI00922649   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYV1
IntAct (EBI)Q9BYV1
FunCoupENSG00000113492
BioGRIDAGXT2
STRING (EMBL)AGXT2
ZODIACAGXT2
Ontologies - Pathways
QuickGOQ9BYV1
Ontology : AmiGOmitochondrion  mitochondrial matrix  alanine-glyoxylate transaminase activity  alanine-glyoxylate transaminase activity  glyoxylate catabolic process  glycine biosynthetic process, by transamination of glyoxylate  L-alanine catabolic process, by transamination  pyridoxal phosphate binding  identical protein binding  positive regulation of nitric oxide biosynthetic process  glyoxylate metabolic process  (R)-3-amino-2-methylpropionate-pyruvate transaminase activity  
Ontology : EGO-EBImitochondrion  mitochondrial matrix  alanine-glyoxylate transaminase activity  alanine-glyoxylate transaminase activity  glyoxylate catabolic process  glycine biosynthetic process, by transamination of glyoxylate  L-alanine catabolic process, by transamination  pyridoxal phosphate binding  identical protein binding  positive regulation of nitric oxide biosynthetic process  glyoxylate metabolic process  (R)-3-amino-2-methylpropionate-pyruvate transaminase activity  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Glycine, serine and threonine metabolism   
NDEx NetworkAGXT2
Atlas of Cancer Signalling NetworkAGXT2
Wikipedia pathwaysAGXT2
Orthology - Evolution
OrthoDB64902
GeneTree (enSembl)ENSG00000113492
Phylogenetic Trees/Animal Genes : TreeFamAGXT2
HOVERGENQ9BYV1
HOGENOMQ9BYV1
Homologs : HomoloGeneAGXT2
Homology/Alignments : Family Browser (UCSC)AGXT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGXT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGXT2
dbVarAGXT2
ClinVarAGXT2
1000_GenomesAGXT2 
Exome Variant ServerAGXT2
ExAC (Exome Aggregation Consortium)AGXT2 (select the gene name)
Genetic variants : HAPMAP64902
Genomic Variants (DGV)AGXT2 [DGVbeta]
DECIPHERAGXT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGXT2 
Mutations
ICGC Data PortalAGXT2 
TCGA Data PortalAGXT2 
Broad Tumor PortalAGXT2
OASIS PortalAGXT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGXT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGXT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AGXT2
DgiDB (Drug Gene Interaction Database)AGXT2
DoCM (Curated mutations)AGXT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGXT2 (select a term)
intoGenAGXT2
Cancer3DAGXT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612471   
Orphanet
MedgenAGXT2
Genetic Testing Registry AGXT2
NextProtQ9BYV1 [Medical]
TSGene64902
GENETestsAGXT2
Target ValidationAGXT2
Huge Navigator AGXT2 [HugePedia]
snp3D : Map Gene to Disease64902
BioCentury BCIQAGXT2
ClinGenAGXT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64902
Chemical/Pharm GKB GenePA24634
Clinical trialAGXT2
Miscellaneous
canSAR (ICR)AGXT2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGXT2
EVEXAGXT2
GoPubMedAGXT2
iHOPAGXT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:01:05 CEST 2017

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