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AHCYL1 (adenosylhomocysteinase like 1)

Identity

Alias_namesS-adenosylhomocysteine hydrolase-like 1
adenosylhomocysteinase-like 1
Alias_symbol (synonym)XPVKONA
IRBIT
PPP1R78
Other aliasDCAL
PRO0233
HGNC (Hugo) AHCYL1
LocusID (NCBI) 10768
Atlas_Id 53083
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 110527387 and ends at 110566364 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AHCYL1 (1p13.3) / AHCYL1 (1p13.3)AHCYL1 (1p13.3) / CDK6 (7q21.2)AHCYL1 (1p13.3) / DDX39B (6p21.33)
AHCYL1 (1p13.3) / DENND2D (1p13.3)AHCYL1 (1p13.3) / LRRC58 (3q13.33)AHCYL1 (1p13.3) / LRRIQ3 (1p31.1)
AHCYL1 (1p13.3) / RAD51C (17q22)AHCYL1 (1p13.3) / RNFT2 (12q24.22)MDC1 (6p21.33) / AHCYL1 (1p13.3)
PDXDC1 (16p13.11) / AHCYL1 (1p13.3)RBFOX2 (22q12.3) / AHCYL1 (1p13.3)AHCYL1 1p13.3 / DENND2D 1p13.3
AHCYL1 1p13.3 / LRRIQ3 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AHCYL1   344
Cards
Entrez_Gene (NCBI)AHCYL1  10768  adenosylhomocysteinase like 1
AliasesDCAL; IRBIT; PPP1R78; PRO0233; 
XPVKONA
GeneCards (Weizmann)AHCYL1
Ensembl hg19 (Hinxton)ENSG00000168710 [Gene_View]  chr1:110527387-110566364 [Contig_View]  AHCYL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168710 [Gene_View]  chr1:110527387-110566364 [Contig_View]  AHCYL1 [Vega]
ICGC DataPortalENSG00000168710
TCGA cBioPortalAHCYL1
AceView (NCBI)AHCYL1
Genatlas (Paris)AHCYL1
WikiGenes10768
SOURCE (Princeton)AHCYL1
Genetics Home Reference (NIH)AHCYL1
Genomic and cartography
GoldenPath hg19 (UCSC)AHCYL1  -     chr1:110527387-110566364 +  1p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AHCYL1  -     1p13.3   [Description]    (hg38-Dec_2013)
EnsemblAHCYL1 - 1p13.3 [CytoView hg19]  AHCYL1 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIAHCYL1 [Mapview hg19]  AHCYL1 [Mapview hg38]
OMIM607826   
Gene and transcription
Genbank (Entrez)AA427939 AA865152 AF035319 AF090905 AF315687
RefSeq transcript (Entrez)NM_001242673 NM_001242674 NM_001242675 NM_001242676 NM_006621
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_029182 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)AHCYL1
Cluster EST : UnigeneHs.743973 [ NCBI ]
CGAP (NCI)Hs.743973
Alternative Splicing GalleryENSG00000168710
Gene ExpressionAHCYL1 [ NCBI-GEO ]   AHCYL1 [ EBI - ARRAY_EXPRESS ]   AHCYL1 [ SEEK ]   AHCYL1 [ MEM ]
Gene Expression Viewer (FireBrowse)AHCYL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10768
GTEX Portal (Tissue expression)AHCYL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43865   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43865  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43865
Splice isoforms : SwissVarO43865
Catalytic activity : Enzyme3.3.1.1 [ Enzyme-Expasy ]   3.3.1.13.3.1.1 [ IntEnz-EBI ]   3.3.1.1 [ BRENDA ]   3.3.1.1 [ KEGG ]   
PhosPhoSitePlusO43865
Domaine pattern : Prosite (Expaxy)ADOHCYASE_1 (PS00738)    ADOHCYASE_2 (PS00739)   
Domains : Interpro (EBI)Adenosylhomocysteinase    Ado_hCys_hydrolase_NAD-bd    NAD(P)-bd_dom    S-Ado-L-homoCys_hydrolase_CS   
Domain families : Pfam (Sanger)AdoHcyase (PF05221)    AdoHcyase_NAD (PF00670)   
Domain families : Pfam (NCBI)pfam05221    pfam00670   
Domain families : Smart (EMBL)AdoHcyase (SM00996)  AdoHcyase_NAD (SM00997)  
Conserved Domain (NCBI)AHCYL1
DMDM Disease mutations10768
Blocks (Seattle)AHCYL1
PDB (SRS)3MTG   
PDB (PDBSum)3MTG   
PDB (IMB)3MTG   
PDB (RSDB)3MTG   
Structural Biology KnowledgeBase3MTG   
SCOP (Structural Classification of Proteins)3MTG   
CATH (Classification of proteins structures)3MTG   
SuperfamilyO43865
Human Protein AtlasENSG00000168710
Peptide AtlasO43865
HPRD07613
IPIIPI00182938   IPI00479201   IPI00441992   IPI00022976   
Protein Interaction databases
DIP (DOE-UCLA)O43865
IntAct (EBI)O43865
FunCoupENSG00000168710
BioGRIDAHCYL1
STRING (EMBL)AHCYL1
ZODIACAHCYL1
Ontologies - Pathways
QuickGOO43865
Ontology : AmiGORNA binding  adenosylhomocysteinase activity  protein binding  cytoplasm  endoplasmic reticulum membrane  cytosol  mRNA polyadenylation  protein export from nucleus  one-carbon metabolic process  biological_process  positive regulation of sodium ion transport  apical plasma membrane  regulation of mRNA 3'-end processing  regulation of ion transmembrane transporter activity  S-adenosylmethionine cycle  angiotensin-activated signaling pathway  epithelial fluid transport  regulation of anion transport  response to calcium ion  extracellular exosome  regulation of cardiac conduction  
Ontology : EGO-EBIRNA binding  adenosylhomocysteinase activity  protein binding  cytoplasm  endoplasmic reticulum membrane  cytosol  mRNA polyadenylation  protein export from nucleus  one-carbon metabolic process  biological_process  positive regulation of sodium ion transport  apical plasma membrane  regulation of mRNA 3'-end processing  regulation of ion transmembrane transporter activity  S-adenosylmethionine cycle  angiotensin-activated signaling pathway  epithelial fluid transport  regulation of anion transport  response to calcium ion  extracellular exosome  regulation of cardiac conduction  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkAHCYL1
Atlas of Cancer Signalling NetworkAHCYL1
Wikipedia pathwaysAHCYL1
Orthology - Evolution
OrthoDB10768
GeneTree (enSembl)ENSG00000168710
Phylogenetic Trees/Animal Genes : TreeFamAHCYL1
HOVERGENO43865
HOGENOMO43865
Homologs : HomoloGeneAHCYL1
Homology/Alignments : Family Browser (UCSC)AHCYL1
Gene fusions - Rearrangements
Fusion : MitelmanAHCYL1/DENND2D [1p13.3/1p13.3]  
Fusion : MitelmanAHCYL1/LRRIQ3 [1p13.3/1p31.1]  [t(1;1)(p13;p31)]  
Fusion : MitelmanAHCYL1/RAD51C [1p13.3/17q22]  [t(1;17)(p13;q22)]  
Fusion: TCGAAHCYL1 1p13.3 DENND2D 1p13.3 BRCA
Fusion: TCGAAHCYL1 1p13.3 LRRIQ3 1p31.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAHCYL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AHCYL1
dbVarAHCYL1
ClinVarAHCYL1
1000_GenomesAHCYL1 
Exome Variant ServerAHCYL1
ExAC (Exome Aggregation Consortium)AHCYL1 (select the gene name)
Genetic variants : HAPMAP10768
Genomic Variants (DGV)AHCYL1 [DGVbeta]
DECIPHER (Syndromes)1:110527387-110566364  ENSG00000168710
CONAN: Copy Number AnalysisAHCYL1 
Mutations
ICGC Data PortalAHCYL1 
TCGA Data PortalAHCYL1 
Broad Tumor PortalAHCYL1
OASIS PortalAHCYL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAHCYL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAHCYL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AHCYL1
DgiDB (Drug Gene Interaction Database)AHCYL1
DoCM (Curated mutations)AHCYL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AHCYL1 (select a term)
intoGenAHCYL1
Cancer3DAHCYL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607826   
Orphanet
MedgenAHCYL1
Genetic Testing Registry AHCYL1
NextProtO43865 [Medical]
TSGene10768
GENETestsAHCYL1
Huge Navigator AHCYL1 [HugePedia]
snp3D : Map Gene to Disease10768
BioCentury BCIQAHCYL1
ClinGenAHCYL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10768
Chemical/Pharm GKB GenePA24637
Clinical trialAHCYL1
Miscellaneous
canSAR (ICR)AHCYL1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAHCYL1
EVEXAHCYL1
GoPubMedAHCYL1
iHOPAHCYL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:56 CEST 2017

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