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AHCYL2 (adenosylhomocysteinase like 2)

Identity

Alias_namesS-adenosylhomocysteine hydrolase-like 2
Alias_symbol (synonym)KIAA0828
Other aliasADOHCYASE3
IRBIT2
HGNC (Hugo) AHCYL2
LocusID (NCBI) 23382
Atlas_Id 53066
Location 7q32.1  [Link to chromosome band 7q32]
Location_base_pair Starts at 129225014 and ends at 129430211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AHCYL2 (7q32.1) / PTGES3 (12q13.3)AHCYL2 (7q32.1) / SND1 (7q32.1)AHCYL2 (7q32.1) / YME1L1 (10p12.1)
CD244 (1q23.3) / AHCYL2 (7q32.1)CELF2 (10p14) / AHCYL2 (7q32.1)CUX1 (7q22.1) / AHCYL2 (7q32.1)
AHCYL2 7q32.1 / SND1 7q32.1CUX1 7q22.1 / AHCYL2 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AHCYL2   22204
Cards
Entrez_Gene (NCBI)AHCYL2  23382  adenosylhomocysteinase like 2
AliasesADOHCYASE3; IRBIT2
GeneCards (Weizmann)AHCYL2
Ensembl hg19 (Hinxton)ENSG00000158467 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158467 [Gene_View]  chr7:129225014-129430211 [Contig_View]  AHCYL2 [Vega]
ICGC DataPortalENSG00000158467
TCGA cBioPortalAHCYL2
AceView (NCBI)AHCYL2
Genatlas (Paris)AHCYL2
WikiGenes23382
SOURCE (Princeton)AHCYL2
Genetics Home Reference (NIH)AHCYL2
Genomic and cartography
GoldenPath hg38 (UCSC)AHCYL2  -     chr7:129225014-129430211 +  7q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AHCYL2  -     7q32.1   [Description]    (hg19-Feb_2009)
EnsemblAHCYL2 - 7q32.1 [CytoView hg19]  AHCYL2 - 7q32.1 [CytoView hg38]
Mapping of homologs : NCBIAHCYL2 [Mapview hg19]  AHCYL2 [Mapview hg38]
OMIM616520   
Gene and transcription
Genbank (Entrez)AB020635 AK025372 AK295851 AK316073 BC008349
RefSeq transcript (Entrez)NM_001130720 NM_001130722 NM_001130723 NM_015328
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AHCYL2
Cluster EST : UnigeneHs.600789 [ NCBI ]
CGAP (NCI)Hs.600789
Alternative Splicing GalleryENSG00000158467
Gene ExpressionAHCYL2 [ NCBI-GEO ]   AHCYL2 [ EBI - ARRAY_EXPRESS ]   AHCYL2 [ SEEK ]   AHCYL2 [ MEM ]
Gene Expression Viewer (FireBrowse)AHCYL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23382
GTEX Portal (Tissue expression)AHCYL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HN2
Splice isoforms : SwissVarQ96HN2
Catalytic activity : Enzyme3.3.1.1 [ Enzyme-Expasy ]   3.3.1.13.3.1.1 [ IntEnz-EBI ]   3.3.1.1 [ BRENDA ]   3.3.1.1 [ KEGG ]   
PhosPhoSitePlusQ96HN2
Domaine pattern : Prosite (Expaxy)ADOHCYASE_1 (PS00738)    ADOHCYASE_2 (PS00739)   
Domains : Interpro (EBI)Adenosylhomocysteinase-like    Ado_hCys_hydrolase_NAD-bd    NAD(P)-bd_dom    S-Ado-L-homoCys_hydrolase_CS   
Domain families : Pfam (Sanger)AdoHcyase (PF05221)    AdoHcyase_NAD (PF00670)   
Domain families : Pfam (NCBI)pfam05221    pfam00670   
Domain families : Smart (EMBL)AdoHcyase (SM00996)  AdoHcyase_NAD (SM00997)  
Conserved Domain (NCBI)AHCYL2
DMDM Disease mutations23382
Blocks (Seattle)AHCYL2
PDB (SRS)3GVP   
PDB (PDBSum)3GVP   
PDB (IMB)3GVP   
PDB (RSDB)3GVP   
Structural Biology KnowledgeBase3GVP   
SCOP (Structural Classification of Proteins)3GVP   
CATH (Classification of proteins structures)3GVP   
SuperfamilyQ96HN2
Human Protein AtlasENSG00000158467
Peptide AtlasQ96HN2
HPRD11113
IPIIPI00101645   IPI00908473   IPI00878976   IPI00942978   IPI00910338   IPI00945758   IPI00944892   
Protein Interaction databases
DIP (DOE-UCLA)Q96HN2
IntAct (EBI)Q96HN2
FunCoupENSG00000158467
BioGRIDAHCYL2
STRING (EMBL)AHCYL2
ZODIACAHCYL2
Ontologies - Pathways
QuickGOQ96HN2
Ontology : AmiGOadenosylhomocysteinase activity  protein binding  endoplasmic reticulum  cytosol  one-carbon metabolic process  S-adenosylmethionine cycle  neuron projection  
Ontology : EGO-EBIadenosylhomocysteinase activity  protein binding  endoplasmic reticulum  cytosol  one-carbon metabolic process  S-adenosylmethionine cycle  neuron projection  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkAHCYL2
Atlas of Cancer Signalling NetworkAHCYL2
Wikipedia pathwaysAHCYL2
Orthology - Evolution
OrthoDB23382
GeneTree (enSembl)ENSG00000158467
Phylogenetic Trees/Animal Genes : TreeFamAHCYL2
HOVERGENQ96HN2
HOGENOMQ96HN2
Homologs : HomoloGeneAHCYL2
Homology/Alignments : Family Browser (UCSC)AHCYL2
Gene fusions - Rearrangements
Fusion : MitelmanAHCYL2/SND1 [7q32.1/7q32.1]  
Fusion : MitelmanCUX1/AHCYL2 [7q22.1/7q32.1]  [t(7;7)(q22;q32)]  
Fusion: TCGAAHCYL2 7q32.1 SND1 7q32.1 PRAD
Fusion: TCGACUX1 7q22.1 AHCYL2 7q32.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAHCYL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AHCYL2
dbVarAHCYL2
ClinVarAHCYL2
1000_GenomesAHCYL2 
Exome Variant ServerAHCYL2
ExAC (Exome Aggregation Consortium)AHCYL2 (select the gene name)
Genetic variants : HAPMAP23382
Genomic Variants (DGV)AHCYL2 [DGVbeta]
DECIPHERAHCYL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAHCYL2 
Mutations
ICGC Data PortalAHCYL2 
TCGA Data PortalAHCYL2 
Broad Tumor PortalAHCYL2
OASIS PortalAHCYL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAHCYL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAHCYL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AHCYL2
DgiDB (Drug Gene Interaction Database)AHCYL2
DoCM (Curated mutations)AHCYL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AHCYL2 (select a term)
intoGenAHCYL2
Cancer3DAHCYL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616520   
Orphanet
MedgenAHCYL2
Genetic Testing Registry AHCYL2
NextProtQ96HN2 [Medical]
TSGene23382
GENETestsAHCYL2
Target ValidationAHCYL2
Huge Navigator AHCYL2 [HugePedia]
snp3D : Map Gene to Disease23382
BioCentury BCIQAHCYL2
ClinGenAHCYL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23382
Chemical/Pharm GKB GenePA162376046
Clinical trialAHCYL2
Miscellaneous
canSAR (ICR)AHCYL2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAHCYL2
EVEXAHCYL2
GoPubMedAHCYL2
iHOPAHCYL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:23:11 CEST 2017

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