AHNAK (AHNAK nucleoprotein)

2013-08-01  

Identity

HGNC
AHNAK
LOCATION
11q12.3
LOCUSID
79026
ALIAS
AHNAKRS,PM227
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79026
MIM: 103390
HGNC: 347
Ensembl: ENSG00000124942

Variants:

dbSNP: 79026
ClinVar: 79026
TCGA: ENSG00000124942
COSMIC: AHNAK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124942ENST00000257247Q09666
ENSG00000124942ENST00000378024Q09666
ENSG00000124942ENST00000528508E9PKR9
ENSG00000124942ENST00000530124E9PJC6
ENSG00000124942ENST00000530285E9PLK4
ENSG00000124942ENST00000531324E9PQE3
ENSG00000124942ENST00000533365E9PJZ0

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121539882002The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton.35
183345792008Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle.31
163191402005Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.23
234091832013AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.23
239311522014The Annexin A2/p11 complex is required for efficient invasion of Salmonella Typhimurium in epithelial cells.19
150339862004AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.18
169849132006Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.17
284947972017AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer.16
229405832012Structure of an asymmetric ternary protein complex provides insight for membrane interaction.15
273741782016AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility.15

Citation

Dessen P

AHNAK (AHNAK nucleoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53725/ahnak