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AHR (aryl hydrocarbon receptor)

Identity

Alias_symbol (synonym)bHLHe76
Other alias
HGNC (Hugo) AHR
LocusID (NCBI) 196
Atlas_Id 598
Location 7p21.1  [Link to chromosome band 7p21]
Location_base_pair Starts at 17298652 and ends at 17346151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHR (7p21.1) / AHR (7p21.1)AHR (7p21.1) / CCDC144CP (17p11.2)AHR (7p21.1) / CDK14 (7q21.13)
BRWD1 (21q22.2) / AHR (7p21.1)AHR 7p21.1 / CDK14 7q21.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  idic(7)(q11.2)
t(1;12)(q21;p13) ETV6/ARNT


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Soft Tissues: Angiofibroma
t(7;7)(p21;q21) AHR/CDK14


External links

Nomenclature
HGNC (Hugo)AHR   348
Cards
Entrez_Gene (NCBI)AHR  196  aryl hydrocarbon receptor
AliasesbHLHe76
GeneCards (Weizmann)AHR
Ensembl hg19 (Hinxton)ENSG00000106546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106546 [Gene_View]  chr7:17298652-17346151 [Contig_View]  AHR [Vega]
ICGC DataPortalENSG00000106546
TCGA cBioPortalAHR
AceView (NCBI)AHR
Genatlas (Paris)AHR
WikiGenes196
SOURCE (Princeton)AHR
Genetics Home Reference (NIH)AHR
Genomic and cartography
GoldenPath hg38 (UCSC)AHR  -     chr7:17298652-17346151 +  7p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AHR  -     7p21.1   [Description]    (hg19-Feb_2009)
EnsemblAHR - 7p21.1 [CytoView hg19]  AHR - 7p21.1 [CytoView hg38]
Mapping of homologs : NCBIAHR [Mapview hg19]  AHR [Mapview hg38]
OMIM600253   
Gene and transcription
Genbank (Entrez)AA329775 AK130815 AK307495 BC021696 BC069390
RefSeq transcript (Entrez)NM_001621
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AHR
Cluster EST : UnigeneHs.171189 [ NCBI ]
CGAP (NCI)Hs.171189
Alternative Splicing GalleryENSG00000106546
Gene ExpressionAHR [ NCBI-GEO ]   AHR [ EBI - ARRAY_EXPRESS ]   AHR [ SEEK ]   AHR [ MEM ]
Gene Expression Viewer (FireBrowse)AHR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196
GTEX Portal (Tissue expression)AHR
Human Protein AtlasENSG00000106546-AHR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35869   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35869  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35869
Splice isoforms : SwissVarP35869
PhosPhoSitePlusP35869
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)AHR    bHLH_dom    PAC    PAS    PAS_fold    PAS_fold_3   
Domain families : Pfam (Sanger)HLH (PF00010)    PAS (PF00989)    PAS_3 (PF08447)   
Domain families : Pfam (NCBI)pfam00010    pfam00989    pfam08447   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
Conserved Domain (NCBI)AHR
DMDM Disease mutations196
Blocks (Seattle)AHR
SuperfamilyP35869
Human Protein Atlas [tissue]ENSG00000106546-AHR [tissue]
Peptide AtlasP35869
HPRD02596
IPIIPI00021008   
Protein Interaction databases
DIP (DOE-UCLA)P35869
IntAct (EBI)P35869
FunCoupENSG00000106546
BioGRIDAHR
STRING (EMBL)AHR
ZODIACAHR
Ontologies - Pathways
QuickGOP35869
Ontology : AmiGOTFIID-class transcription factor binding  transcription coactivator binding  blood vessel development  DNA binding  DNA binding  DNA binding transcription factor activity  aryl hydrocarbon receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  xenobiotic metabolic process  apoptotic process  cell cycle  transcription factor binding  response to xenobiotic stimulus  response to toxic substance  regulation of gene expression  TBP-class protein binding  cAMP-mediated signaling  intracellular receptor signaling pathway  regulation of B cell proliferation  circadian regulation of gene expression  cytosolic aryl hydrocarbon receptor complex  nuclear aryl hydrocarbon receptor complex  enhancer binding  protein complex  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  protein dimerization activity  Hsp90 protein binding  E-box binding  cellular response to cAMP  cellular response to forskolin  cellular response to 2,3,7,8-tetrachlorodibenzodioxine  
Ontology : EGO-EBITFIID-class transcription factor binding  transcription coactivator binding  blood vessel development  DNA binding  DNA binding  DNA binding transcription factor activity  aryl hydrocarbon receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  xenobiotic metabolic process  apoptotic process  cell cycle  transcription factor binding  response to xenobiotic stimulus  response to toxic substance  regulation of gene expression  TBP-class protein binding  cAMP-mediated signaling  intracellular receptor signaling pathway  regulation of B cell proliferation  circadian regulation of gene expression  cytosolic aryl hydrocarbon receptor complex  nuclear aryl hydrocarbon receptor complex  enhancer binding  protein complex  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  protein dimerization activity  Hsp90 protein binding  E-box binding  cellular response to cAMP  cellular response to forskolin  cellular response to 2,3,7,8-tetrachlorodibenzodioxine  
Pathways : BIOCARTAAhr Signal Transduction Pathway [Genes]   
NDEx NetworkAHR
Atlas of Cancer Signalling NetworkAHR
Wikipedia pathwaysAHR
Orthology - Evolution
OrthoDB196
GeneTree (enSembl)ENSG00000106546
Phylogenetic Trees/Animal Genes : TreeFamAHR
HOVERGENP35869
HOGENOMP35869
Homologs : HomoloGeneAHR
Homology/Alignments : Family Browser (UCSC)AHR
Gene fusions - Rearrangements
Fusion : MitelmanAHR/CDK14 [7p21.1/7q21.13]  
Fusion: TCGA_MDACCAHR 7p21.1 CDK14 7q21.13 BRCA
Fusion PortalAHR 7p21.1 CDK14 7q21.13 BRCA
Fusion : QuiverAHR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAHR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AHR
dbVarAHR
ClinVarAHR
1000_GenomesAHR 
Exome Variant ServerAHR
ExAC (Exome Aggregation Consortium)ENSG00000106546
GNOMAD BrowserENSG00000106546
Genetic variants : HAPMAP196
Genomic Variants (DGV)AHR [DGVbeta]
DECIPHERAHR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAHR 
Mutations
ICGC Data PortalAHR 
TCGA Data PortalAHR 
Broad Tumor PortalAHR
OASIS PortalAHR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAHR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAHR
intOGen PortalAHR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AHR
DgiDB (Drug Gene Interaction Database)AHR
DoCM (Curated mutations)AHR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AHR (select a term)
intoGenAHR
Cancer3DAHR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600253   
Orphanet
DisGeNETAHR
MedgenAHR
Genetic Testing Registry AHR
NextProtP35869 [Medical]
TSGene196
GENETestsAHR
Target ValidationAHR
Huge Navigator AHR [HugePedia]
snp3D : Map Gene to Disease196
BioCentury BCIQAHR
ClinGenAHR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD196
Chemical/Pharm GKB GenePA24641
Clinical trialAHR
Miscellaneous
canSAR (ICR)AHR (select the gene name)
Probes
Litterature
PubMed480 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAHR
EVEXAHR
GoPubMedAHR
iHOPAHR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 11:29:12 CEST 2018

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