AICDA (activation induced cytidine deaminase)

2006-10-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
AID,ARP2,CDA2,HEL-S-284,HIGM2

Other Information

Locus ID:

NCBI: 57379
MIM: 605257
HGNC: 13203
Ensembl: ENSG00000111732

Variants:

dbSNP: 57379
ClinVar: 57379
TCGA: ENSG00000111732
COSMIC: AICDA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111732ENST00000229335Q9GZX7
ENSG00000111732ENST00000229335Q546Y9
ENSG00000111732ENST00000537228Q9GZX7
ENSG00000111732ENST00000543081H0YFL3
ENSG00000111732ENST00000544516H0YFP1
ENSG00000111732ENST00000545512H0YGF6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Primary immunodeficiencyKEGGko05340
Primary immunodeficiencyKEGGhsa05340
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672

References

Pubmed IDYearTitleCitations
120979152002AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.307
200271822010Reprogramming towards pluripotency requires AID-dependent DNA demethylation.285
154481522004Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.180
212558252011The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.138
147699372004Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.115
254837772014B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.105
183907092008Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells.103
127994242003Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.98
145360882003C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.98
254837762014Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.89

Citation

Dessen P

AICDA (activation induced cytidine deaminase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43110/aicda