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AJAP1 (adherens junctions associated protein 1)

Identity

Alias_symbol (synonym)SHREW1
SHREW-1
MOT8
Other alias
HGNC (Hugo) AJAP1
LocusID (NCBI) 55966
Atlas_Id 45790
Location 1p36.32  [Link to chromosome band 1p36]
Location_base_pair Starts at 4655045 and ends at 4783791 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;7)(p36;p22) AJAP1/CYTH3


External links

Nomenclature
HGNC (Hugo)AJAP1   30801
Cards
Entrez_Gene (NCBI)AJAP1  55966  adherens junctions associated protein 1
AliasesMOT8; SHREW-1; SHREW1
GeneCards (Weizmann)AJAP1
Ensembl hg19 (Hinxton)ENSG00000196581 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196581 [Gene_View]  ENSG00000196581 [Sequence]  chr1:4655045-4783791 [Contig_View]  AJAP1 [Vega]
ICGC DataPortalENSG00000196581
TCGA cBioPortalAJAP1
AceView (NCBI)AJAP1
Genatlas (Paris)AJAP1
WikiGenes55966
SOURCE (Princeton)AJAP1
Genetics Home Reference (NIH)AJAP1
Genomic and cartography
GoldenPath hg38 (UCSC)AJAP1  -     chr1:4655045-4783791 +  1p36.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AJAP1  -     1p36.32   [Description]    (hg19-Feb_2009)
EnsemblAJAP1 - 1p36.32 [CytoView hg19]  AJAP1 - 1p36.32 [CytoView hg38]
Mapping of homologs : NCBIAJAP1 [Mapview hg19]  AJAP1 [Mapview hg38]
OMIM610972   
Gene and transcription
Genbank (Entrez)AF052109 AF052143 AF175409 AL049672 AL049673
RefSeq transcript (Entrez)NM_001042478 NM_018836
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AJAP1
Cluster EST : UnigeneHs.25924 [ NCBI ]
CGAP (NCI)Hs.25924
Alternative Splicing GalleryENSG00000196581
Gene ExpressionAJAP1 [ NCBI-GEO ]   AJAP1 [ EBI - ARRAY_EXPRESS ]   AJAP1 [ SEEK ]   AJAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)AJAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55966
GTEX Portal (Tissue expression)AJAP1
Human Protein AtlasENSG00000196581-AJAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKB5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKB5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKB5
Splice isoforms : SwissVarQ9UKB5
PhosPhoSitePlusQ9UKB5
Domains : Interpro (EBI)AJAP1_PANP_C   
Domain families : Pfam (Sanger)AJAP1_PANP_C (PF15298)   
Domain families : Pfam (NCBI)pfam15298   
Conserved Domain (NCBI)AJAP1
DMDM Disease mutations55966
Blocks (Seattle)AJAP1
SuperfamilyQ9UKB5
Human Protein Atlas [tissue]ENSG00000196581-AJAP1 [tissue]
Peptide AtlasQ9UKB5
HPRD15339
IPIIPI00001399   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKB5
IntAct (EBI)Q9UKB5
FunCoupENSG00000196581
BioGRIDAJAP1
STRING (EMBL)AJAP1
ZODIACAJAP1
Ontologies - Pathways
QuickGOQ9UKB5
Ontology : AmiGOnegative regulation of cell-matrix adhesion  cell-cell adherens junction  cell adhesion  beta-catenin binding  cytoplasmic side of plasma membrane  cell surface  basolateral plasma membrane  apical plasma membrane  regulation of polarized epithelial cell differentiation  protein complex binding  spanning component of plasma membrane  cell-cell contact zone  negative regulation of wound healing  
Ontology : EGO-EBInegative regulation of cell-matrix adhesion  cell-cell adherens junction  cell adhesion  beta-catenin binding  cytoplasmic side of plasma membrane  cell surface  basolateral plasma membrane  apical plasma membrane  regulation of polarized epithelial cell differentiation  protein complex binding  spanning component of plasma membrane  cell-cell contact zone  negative regulation of wound healing  
NDEx NetworkAJAP1
Atlas of Cancer Signalling NetworkAJAP1
Wikipedia pathwaysAJAP1
Orthology - Evolution
OrthoDB55966
GeneTree (enSembl)ENSG00000196581
Phylogenetic Trees/Animal Genes : TreeFamAJAP1
HOVERGENQ9UKB5
HOGENOMQ9UKB5
Homologs : HomoloGeneAJAP1
Homology/Alignments : Family Browser (UCSC)AJAP1
Gene fusions - Rearrangements
Fusion : QuiverAJAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAJAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AJAP1
dbVarAJAP1
ClinVarAJAP1
1000_GenomesAJAP1 
Exome Variant ServerAJAP1
ExAC (Exome Aggregation Consortium)ENSG00000196581
GNOMAD BrowserENSG00000196581
Genetic variants : HAPMAP55966
Genomic Variants (DGV)AJAP1 [DGVbeta]
DECIPHERAJAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAJAP1 
Mutations
ICGC Data PortalAJAP1 
TCGA Data PortalAJAP1 
Broad Tumor PortalAJAP1
OASIS PortalAJAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAJAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAJAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AJAP1
DgiDB (Drug Gene Interaction Database)AJAP1
DoCM (Curated mutations)AJAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AJAP1 (select a term)
intoGenAJAP1
Cancer3DAJAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610972   
Orphanet
DisGeNETAJAP1
MedgenAJAP1
Genetic Testing Registry AJAP1
NextProtQ9UKB5 [Medical]
TSGene55966
GENETestsAJAP1
Target ValidationAJAP1
Huge Navigator AJAP1 [HugePedia]
snp3D : Map Gene to Disease55966
BioCentury BCIQAJAP1
ClinGenAJAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55966
Chemical/Pharm GKB GenePA142672629
Clinical trialAJAP1
Miscellaneous
canSAR (ICR)AJAP1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAJAP1
EVEXAJAP1
GoPubMedAJAP1
iHOPAJAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:13:35 CEST 2018

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