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AK2 (adenylate kinase 2)

Identity

Other aliasADK2
HGNC (Hugo) AK2
LocusID (NCBI) 204
Atlas_Id 606
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 33007940 and ends at 33036911 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AK2   362
LRG (Locus Reference Genomic)LRG_133
Cards
Entrez_Gene (NCBI)AK2  204  adenylate kinase 2
AliasesADK2
GeneCards (Weizmann)AK2
Ensembl hg19 (Hinxton)ENSG00000004455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004455 [Gene_View]  chr1:33007940-33036911 [Contig_View]  AK2 [Vega]
ICGC DataPortalENSG00000004455
TCGA cBioPortalAK2
AceView (NCBI)AK2
Genatlas (Paris)AK2
WikiGenes204
SOURCE (Princeton)AK2
Genetics Home Reference (NIH)AK2
Genomic and cartography
GoldenPath hg38 (UCSC)AK2  -     chr1:33007940-33036911 -  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AK2  -     1p35.1   [Description]    (hg19-Feb_2009)
EnsemblAK2 - 1p35.1 [CytoView hg19]  AK2 - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIAK2 [Mapview hg19]  AK2 [Mapview hg38]
OMIM103020   267500   
Gene and transcription
Genbank (Entrez)AB005621 AB005622 AB451267 AB451394 AK023758
RefSeq transcript (Entrez)NM_001199199 NM_001319139 NM_001319140 NM_001319141 NM_001319142 NM_001319143 NM_001625 NM_013411
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AK2
Cluster EST : UnigeneHs.470907 [ NCBI ]
CGAP (NCI)Hs.470907
Alternative Splicing GalleryENSG00000004455
Gene ExpressionAK2 [ NCBI-GEO ]   AK2 [ EBI - ARRAY_EXPRESS ]   AK2 [ SEEK ]   AK2 [ MEM ]
Gene Expression Viewer (FireBrowse)AK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)204
GTEX Portal (Tissue expression)AK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54819   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54819  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54819
Splice isoforms : SwissVarP54819
PhosPhoSitePlusP54819
Domaine pattern : Prosite (Expaxy)ADENYLATE_KINASE (PS00113)   
Domains : Interpro (EBI)Adenyl_kin_sub    Adenylat/UMP-CMP_kin    Adenylat_kinase_CS    Adenylate_kinase_lid-dom    AK2    P-loop_NTPase   
Domain families : Pfam (Sanger)ADK_lid (PF05191)   
Domain families : Pfam (NCBI)pfam05191   
Conserved Domain (NCBI)AK2
DMDM Disease mutations204
Blocks (Seattle)AK2
PDB (SRS)2C9Y   
PDB (PDBSum)2C9Y   
PDB (IMB)2C9Y   
PDB (RSDB)2C9Y   
Structural Biology KnowledgeBase2C9Y   
SCOP (Structural Classification of Proteins)2C9Y   
CATH (Classification of proteins structures)2C9Y   
SuperfamilyP54819
Human Protein AtlasENSG00000004455
Peptide AtlasP54819
HPRD00047
IPIIPI00215901   IPI00218988   IPI00172460   IPI00922165   IPI00921960   IPI00218989   IPI01020958   IPI01021158   IPI01022481   IPI01022632   
Protein Interaction databases
DIP (DOE-UCLA)P54819
IntAct (EBI)P54819
FunCoupENSG00000004455
BioGRIDAK2
STRING (EMBL)AK2
ZODIACAK2
Ontologies - Pathways
QuickGOP54819
Ontology : AmiGOadenylate kinase activity  ATP binding  mitochondrial inner membrane  mitochondrial intermembrane space  ADP biosynthetic process  nucleobase-containing small molecule interconversion  nucleotide phosphorylation  extracellular exosome  sperm mitochondrial sheath  
Ontology : EGO-EBIadenylate kinase activity  ATP binding  mitochondrial inner membrane  mitochondrial intermembrane space  ADP biosynthetic process  nucleobase-containing small molecule interconversion  nucleotide phosphorylation  extracellular exosome  sperm mitochondrial sheath  
Pathways : KEGGPurine metabolism   
NDEx NetworkAK2
Atlas of Cancer Signalling NetworkAK2
Wikipedia pathwaysAK2
Orthology - Evolution
OrthoDB204
GeneTree (enSembl)ENSG00000004455
Phylogenetic Trees/Animal Genes : TreeFamAK2
HOVERGENP54819
HOGENOMP54819
Homologs : HomoloGeneAK2
Homology/Alignments : Family Browser (UCSC)AK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AK2
dbVarAK2
ClinVarAK2
1000_GenomesAK2 
Exome Variant ServerAK2
ExAC (Exome Aggregation Consortium)AK2 (select the gene name)
Genetic variants : HAPMAP204
Genomic Variants (DGV)AK2 [DGVbeta]
DECIPHERAK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAK2 
Mutations
ICGC Data PortalAK2 
TCGA Data PortalAK2 
Broad Tumor PortalAK2
OASIS PortalAK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AK2
DgiDB (Drug Gene Interaction Database)AK2
DoCM (Curated mutations)AK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AK2 (select a term)
intoGenAK2
Cancer3DAK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103020    267500   
Orphanet10318   
MedgenAK2
Genetic Testing Registry AK2
NextProtP54819 [Medical]
TSGene204
GENETestsAK2
Target ValidationAK2
Huge Navigator AK2 [HugePedia]
snp3D : Map Gene to Disease204
BioCentury BCIQAK2
ClinGenAK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD204
Chemical/Pharm GKB GenePA24656
Clinical trialAK2
Miscellaneous
canSAR (ICR)AK2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAK2
EVEXAK2
GoPubMedAK2
iHOPAK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:54:41 CEST 2017

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