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AK3 (adenylate kinase 3)

Identity

Alias_namesAK6
AK3L1
adenylate kinase 6
adenylate kinase 3 like 1
Alias_symbol (synonym)AKL3L1
Other aliasAKL3L
FIX
HGNC (Hugo) AK3
LocusID (NCBI) 50808
Atlas_Id 43112
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 4709556 and ends at 4741309 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AK3 (9p24.1) / CDC27 (17q21.32)AK3 (9p24.1) / DOCK8 (9p24.3)AK3 (9p24.1) / EHMT1 (9q34.3)
AK3 (9p24.1) / RCL1 (9p24.1)SFTPB (2p11.2) / AK3 (9p24.1)AK3 9p24.1 / DOCK8 9p24.3
AK3 9p24.1 / RCL1 9p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AK3   17376
Cards
Entrez_Gene (NCBI)AK3  50808  adenylate kinase 3
AliasesAK3L1; AK6; AKL3L; AKL3L1; 
FIX
GeneCards (Weizmann)AK3
Ensembl hg19 (Hinxton)ENSG00000147853 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147853 [Gene_View]  chr9:4709556-4741309 [Contig_View]  AK3 [Vega]
ICGC DataPortalENSG00000147853
TCGA cBioPortalAK3
AceView (NCBI)AK3
Genatlas (Paris)AK3
WikiGenes50808
SOURCE (Princeton)AK3
Genetics Home Reference (NIH)AK3
Genomic and cartography
GoldenPath hg38 (UCSC)AK3  -     chr9:4709556-4741309 -  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AK3  -     9p24.1   [Description]    (hg19-Feb_2009)
EnsemblAK3 - 9p24.1 [CytoView hg19]  AK3 - 9p24.1 [CytoView hg38]
Mapping of homologs : NCBIAK3 [Mapview hg19]  AK3 [Mapview hg38]
OMIM609290   
Gene and transcription
Genbank (Entrez)AB021870 AF086913 AF100785 AF183419 AK001553
RefSeq transcript (Entrez)NM_001199852 NM_001199853 NM_001199854 NM_001199855 NM_001199856 NM_016282
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AK3
Cluster EST : UnigeneHs.732022 [ NCBI ]
CGAP (NCI)Hs.732022
Alternative Splicing GalleryENSG00000147853
Gene ExpressionAK3 [ NCBI-GEO ]   AK3 [ EBI - ARRAY_EXPRESS ]   AK3 [ SEEK ]   AK3 [ MEM ]
Gene Expression Viewer (FireBrowse)AK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50808
GTEX Portal (Tissue expression)AK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIJ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIJ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIJ7
Splice isoforms : SwissVarQ9UIJ7
PhosPhoSitePlusQ9UIJ7
Domaine pattern : Prosite (Expaxy)ADENYLATE_KINASE (PS00113)   
Domains : Interpro (EBI)Adenyl_kin_sub    Adenylat/UMP-CMP_kin    Adenylat_kinase_CS    Adenylate_kinase_lid-dom    AK3/Ak4_mitochondrial    P-loop_NTPase   
Domain families : Pfam (Sanger)ADK_lid (PF05191)   
Domain families : Pfam (NCBI)pfam05191   
Conserved Domain (NCBI)AK3
DMDM Disease mutations50808
Blocks (Seattle)AK3
PDB (SRS)1ZD8   
PDB (PDBSum)1ZD8   
PDB (IMB)1ZD8   
PDB (RSDB)1ZD8   
Structural Biology KnowledgeBase1ZD8   
SCOP (Structural Classification of Proteins)1ZD8   
CATH (Classification of proteins structures)1ZD8   
SuperfamilyQ9UIJ7
Human Protein AtlasENSG00000147853
Peptide AtlasQ9UIJ7
HPRD12439
IPIIPI00465256   IPI00910240   IPI00478236   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIJ7
IntAct (EBI)Q9UIJ7
FunCoupENSG00000147853
BioGRIDAK3
STRING (EMBL)AK3
ZODIACAK3
Ontologies - Pathways
QuickGOQ9UIJ7
Ontology : AmiGOadenylate kinase activity  protein binding  ATP binding  GTP binding  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  blood coagulation  phosphorylation  AMP metabolic process  GTP metabolic process  ITP metabolic process  UTP metabolic process  nucleoside triphosphate adenylate kinase activity  nucleoside triphosphate adenylate kinase activity  
Ontology : EGO-EBIadenylate kinase activity  protein binding  ATP binding  GTP binding  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  blood coagulation  phosphorylation  AMP metabolic process  GTP metabolic process  ITP metabolic process  UTP metabolic process  nucleoside triphosphate adenylate kinase activity  nucleoside triphosphate adenylate kinase activity  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkAK3
Atlas of Cancer Signalling NetworkAK3
Wikipedia pathwaysAK3
Orthology - Evolution
OrthoDB50808
GeneTree (enSembl)ENSG00000147853
Phylogenetic Trees/Animal Genes : TreeFamAK3
HOVERGENQ9UIJ7
HOGENOMQ9UIJ7
Homologs : HomoloGeneAK3
Homology/Alignments : Family Browser (UCSC)AK3
Gene fusions - Rearrangements
Fusion : MitelmanAK3/DOCK8 [9p24.1/9p24.3]  
Fusion : MitelmanAK3/RCL1 [9p24.1/9p24.1]  [t(9;9)(p24;p24)]  
Fusion: TCGAAK3 9p24.1 DOCK8 9p24.3 KIRC
Fusion: TCGAAK3 9p24.1 RCL1 9p24.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AK3
dbVarAK3
ClinVarAK3
1000_GenomesAK3 
Exome Variant ServerAK3
ExAC (Exome Aggregation Consortium)AK3 (select the gene name)
Genetic variants : HAPMAP50808
Genomic Variants (DGV)AK3 [DGVbeta]
DECIPHERAK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAK3 
Mutations
ICGC Data PortalAK3 
TCGA Data PortalAK3 
Broad Tumor PortalAK3
OASIS PortalAK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AK3
DgiDB (Drug Gene Interaction Database)AK3
DoCM (Curated mutations)AK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AK3 (select a term)
intoGenAK3
Cancer3DAK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609290   
Orphanet
MedgenAK3
Genetic Testing Registry AK3
NextProtQ9UIJ7 [Medical]
TSGene50808
GENETestsAK3
Target ValidationAK3
Huge Navigator AK3 [HugePedia]
snp3D : Map Gene to Disease50808
BioCentury BCIQAK3
ClinGenAK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50808
Chemical/Pharm GKB GenePA164741184
Clinical trialAK3
Miscellaneous
canSAR (ICR)AK3 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAK3
EVEXAK3
GoPubMedAK3
iHOPAK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:42 CEST 2017

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