AK4 (adenylate kinase 4)

2016-12-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
AK

Other Information

Locus ID:

NCBI: 205
MIM: 103030
HGNC: 363
Ensembl: ENSG00000162433

Variants:

dbSNP: 205
ClinVar: 205
TCGA: ENSG00000162433
COSMIC: AK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162433ENST00000327299P27144
ENSG00000162433ENST00000395334P27144
ENSG00000162433ENST00000545314P27144
ENSG00000162433ENST00000546702D3DQ64

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Thiamine metabolismKEGGko00730
Purine metabolismKEGGhsa00230
Thiamine metabolismKEGGhsa00730
Metabolic pathwaysKEGGhsa01100
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10005adefovir dipivoxilChemicalPathwayassociated
PA10204tenofovirChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
230022112012Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3.31
298660542018MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4.13
269804352016Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.9
197667322010Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.8
234744582013Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.7
306964682019Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis.5
190731422009Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.4
314638322019Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion.2
318276452019AK4 Promotes the Progression of HER2-Positive Breast Cancer by Facilitating Cell Proliferation and Invasion.2

Citation

Dessen P

AK4 (adenylate kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56660/ak4