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AK4 (adenylate kinase 4)

Identity

Other aliasAK 4
AK3
AK3L1
AK3L2
HGNC (Hugo) AK4
LocusID (NCBI) 205
Atlas_Id 56660
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 65147549 and ends at 65232145 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AK4   363
Cards
Entrez_Gene (NCBI)AK4  205  adenylate kinase 4
AliasesAK; AK3; AK3L1; AK3L2
GeneCards (Weizmann)AK4
Ensembl hg19 (Hinxton)ENSG00000162433 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162433 [Gene_View]  ENSG00000162433 [Sequence]  chr1:65147549-65232145 [Contig_View]  AK4 [Vega]
ICGC DataPortalENSG00000162433
TCGA cBioPortalAK4
AceView (NCBI)AK4
Genatlas (Paris)AK4
WikiGenes205
SOURCE (Princeton)AK4
Genetics Home Reference (NIH)AK4
Genomic and cartography
GoldenPath hg38 (UCSC)AK4  -     chr1:65147549-65232145 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AK4  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathAK4 - 1p31.3 [CytoView hg19]  AK4 - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000162433
Mapping of homologs : NCBIAK4 [Mapview hg19]  AK4 [Mapview hg38]
OMIM103030   
Gene and transcription
Genbank (Entrez)AK025926 AK026966 AK309057 AK313611 BC016180
RefSeq transcript (Entrez)NM_001005353 NM_001330616 NM_013410 NM_203464
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AK4
Cluster EST : UnigeneHs.10862 [ NCBI ]
CGAP (NCI)Hs.10862
Alternative Splicing GalleryENSG00000162433
Gene ExpressionAK4 [ NCBI-GEO ]   AK4 [ EBI - ARRAY_EXPRESS ]   AK4 [ SEEK ]   AK4 [ MEM ]
Gene Expression Viewer (FireBrowse)AK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)205
GTEX Portal (Tissue expression)AK4
Human Protein AtlasENSG00000162433-AK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27144
Splice isoforms : SwissVarP27144
PhosPhoSitePlusP27144
Domaine pattern : Prosite (Expaxy)ADENYLATE_KINASE (PS00113)   
Domains : Interpro (EBI)Adenyl_kin_sub    Adenylat/UMP-CMP_kin    Adenylat_kinase_CS    Adenylate_kinase_lid-dom    ADK_active_lid_dom_sf    AK3/Ak4_mitochondrial    AK4_mitochondrial    P-loop_NTPase   
Domain families : Pfam (Sanger)ADK_lid (PF05191)   
Domain families : Pfam (NCBI)pfam05191   
Conserved Domain (NCBI)AK4
DMDM Disease mutations205
Blocks (Seattle)AK4
PDB (RSDB)2AR7    2BBW    3NDP   
PDB Europe2AR7    2BBW    3NDP   
PDB (PDBSum)2AR7    2BBW    3NDP   
PDB (IMB)2AR7    2BBW    3NDP   
Structural Biology KnowledgeBase2AR7    2BBW    3NDP   
SCOP (Structural Classification of Proteins)2AR7    2BBW    3NDP   
CATH (Classification of proteins structures)2AR7    2BBW    3NDP   
SuperfamilyP27144
Human Protein Atlas [tissue]ENSG00000162433-AK4 [tissue]
Peptide AtlasP27144
IPIIPI00973950   
Protein Interaction databases
DIP (DOE-UCLA)P27144
IntAct (EBI)P27144
FunCoupENSG00000162433
BioGRIDAK4
STRING (EMBL)AK4
ZODIACAK4
Ontologies - Pathways
QuickGOP27144
Ontology : AmiGOliver development  adenylate kinase activity  adenylate kinase activity  nucleoside diphosphate kinase activity  ATP binding  GTP binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  nucleoside diphosphate phosphorylation  ADP biosynthetic process  brain development  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  response to drug  AMP metabolic process  ATP metabolic process  GTP metabolic process  nucleoside triphosphate adenylate kinase activity  nucleoside triphosphate adenylate kinase activity  nucleoside monophosphate phosphorylation  nucleoside monophosphate kinase activity  
Ontology : EGO-EBIliver development  adenylate kinase activity  adenylate kinase activity  nucleoside diphosphate kinase activity  ATP binding  GTP binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  nucleoside diphosphate phosphorylation  ADP biosynthetic process  brain development  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  response to drug  AMP metabolic process  ATP metabolic process  GTP metabolic process  nucleoside triphosphate adenylate kinase activity  nucleoside triphosphate adenylate kinase activity  nucleoside monophosphate phosphorylation  nucleoside monophosphate kinase activity  
Pathways : KEGGPurine metabolism   
NDEx NetworkAK4
Atlas of Cancer Signalling NetworkAK4
Wikipedia pathwaysAK4
Orthology - Evolution
OrthoDB205
GeneTree (enSembl)ENSG00000162433
Phylogenetic Trees/Animal Genes : TreeFamAK4
HOGENOMP27144
Homologs : HomoloGeneAK4
Homology/Alignments : Family Browser (UCSC)AK4
Gene fusions - Rearrangements
Fusion : QuiverAK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AK4
dbVarAK4
ClinVarAK4
1000_GenomesAK4 
Exome Variant ServerAK4
ExAC (Exome Aggregation Consortium)ENSG00000162433
GNOMAD BrowserENSG00000162433
Varsome BrowserAK4
Genetic variants : HAPMAP205
Genomic Variants (DGV)AK4 [DGVbeta]
DECIPHERAK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAK4 
Mutations
ICGC Data PortalAK4 
TCGA Data PortalAK4 
Broad Tumor PortalAK4
OASIS PortalAK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAK4
BioMutasearch AK4
DgiDB (Drug Gene Interaction Database)AK4
DoCM (Curated mutations)AK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AK4 (select a term)
intoGenAK4
Cancer3DAK4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103030   
Orphanet
DisGeNETAK4
MedgenAK4
Genetic Testing Registry AK4
NextProtP27144 [Medical]
TSGene205
GENETestsAK4
Target ValidationAK4
Huge Navigator AK4 [HugePedia]
snp3D : Map Gene to Disease205
BioCentury BCIQAK4
ClinGenAK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD205
Chemical/Pharm GKB GenePA165750325
Clinical trialAK4
Miscellaneous
canSAR (ICR)AK4 (select the gene name)
DataMed IndexAK4
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAK4
EVEXAK4
GoPubMedAK4
iHOPAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 17:54:44 CEST 2019
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