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AK5 (adenylate kinase 5)

Identity

Other aliasAK6
HGNC (Hugo) AK5
LocusID (NCBI) 26289
Atlas_Id 43113
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 77748287 and ends at 78025654 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABCD3 (1p21.3) / AK5 (1p31.1)ADGRL2 (1p31.1) / AK5 (1p31.1)FAM49B (8q24.21) / AK5 (1p31.1)
NEXN (1p31.1) / AK5 (1p31.1)ABCD3 1p21.3 / AK5 1p31.1FAM49B 8q24.21 / AK5 1p31.1
LPHN2 AK5 1p31.1NEXN 1p31.1 / AK5 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AK5   365
Cards
Entrez_Gene (NCBI)AK5  26289  adenylate kinase 5
AliasesAK6
GeneCards (Weizmann)AK5
Ensembl hg19 (Hinxton)ENSG00000154027 [Gene_View]  chr1:77748287-78025654 [Contig_View]  AK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154027 [Gene_View]  chr1:77748287-78025654 [Contig_View]  AK5 [Vega]
ICGC DataPortalENSG00000154027
TCGA cBioPortalAK5
AceView (NCBI)AK5
Genatlas (Paris)AK5
WikiGenes26289
SOURCE (Princeton)AK5
Genetics Home Reference (NIH)AK5
Genomic and cartography
GoldenPath hg19 (UCSC)AK5  -     chr1:77748287-78025654 +  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AK5  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblAK5 - 1p31.1 [CytoView hg19]  AK5 - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIAK5 [Mapview hg19]  AK5 [Mapview hg38]
OMIM608009   
Gene and transcription
Genbank (Entrez)AF062595 AF445193 AK090967 AW665223 AY171600
RefSeq transcript (Entrez)NM_012093 NM_174858
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)AK5
Cluster EST : UnigeneHs.597002 [ NCBI ]
CGAP (NCI)Hs.597002
Alternative Splicing GalleryENSG00000154027
Gene ExpressionAK5 [ NCBI-GEO ]   AK5 [ EBI - ARRAY_EXPRESS ]   AK5 [ SEEK ]   AK5 [ MEM ]
Gene Expression Viewer (FireBrowse)AK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26289
GTEX Portal (Tissue expression)AK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6K8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6K8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6K8
Splice isoforms : SwissVarQ9Y6K8
Catalytic activity : Enzyme2.7.4.3 [ Enzyme-Expasy ]   2.7.4.32.7.4.3 [ IntEnz-EBI ]   2.7.4.3 [ BRENDA ]   2.7.4.3 [ KEGG ]   
PhosPhoSitePlusQ9Y6K8
Domaine pattern : Prosite (Expaxy)ADENYLATE_KINASE (PS00113)   
Domains : Interpro (EBI)Adenylat/UMP-CMP_kin    AK1/5    cAMP_dep_PK_reg_su_I/II_a/b    P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)AK5
DMDM Disease mutations26289
Blocks (Seattle)AK5
PDB (SRS)2BWJ   
PDB (PDBSum)2BWJ   
PDB (IMB)2BWJ   
PDB (RSDB)2BWJ   
Structural Biology KnowledgeBase2BWJ   
SCOP (Structural Classification of Proteins)2BWJ   
CATH (Classification of proteins structures)2BWJ   
SuperfamilyQ9Y6K8
Human Protein AtlasENSG00000154027
Peptide AtlasQ9Y6K8
HPRD10472
IPIIPI00943762   IPI00844054   IPI00166342   IPI00743623   IPI00975722   IPI00980215   IPI01008811   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6K8
IntAct (EBI)Q9Y6K8
FunCoupENSG00000154027
BioGRIDAK5
STRING (EMBL)AK5
ZODIACAK5
Ontologies - Pathways
QuickGOQ9Y6K8
Ontology : AmiGOadenylate kinase activity  nucleoside diphosphate kinase activity  ATP binding  cytoplasm  microtubule organizing center  cytosol  nucleoside diphosphate phosphorylation  ADP biosynthetic process  dADP biosynthetic process  nucleoside triphosphate biosynthetic process  pyrimidine ribonucleotide biosynthetic process  nucleobase-containing small molecule interconversion  nucleoside kinase activity  ATP metabolic process  
Ontology : EGO-EBIadenylate kinase activity  nucleoside diphosphate kinase activity  ATP binding  cytoplasm  microtubule organizing center  cytosol  nucleoside diphosphate phosphorylation  ADP biosynthetic process  dADP biosynthetic process  nucleoside triphosphate biosynthetic process  pyrimidine ribonucleotide biosynthetic process  nucleobase-containing small molecule interconversion  nucleoside kinase activity  ATP metabolic process  
Pathways : KEGGPurine metabolism   
NDEx NetworkAK5
Atlas of Cancer Signalling NetworkAK5
Wikipedia pathwaysAK5
Orthology - Evolution
OrthoDB26289
GeneTree (enSembl)ENSG00000154027
Phylogenetic Trees/Animal Genes : TreeFamAK5
HOVERGENQ9Y6K8
HOGENOMQ9Y6K8
Homologs : HomoloGeneAK5
Homology/Alignments : Family Browser (UCSC)AK5
Gene fusions - Rearrangements
Fusion : MitelmanABCD3/AK5 [1p21.3/1p31.1]  [t(1;1)(p21;p31)]  
Fusion : MitelmanADGRL2/AK5 [1p31.1/1p31.1]  [t(1;1)(p31;p31)]  
Fusion : MitelmanFAM49B/AK5 [8q24.21/1p31.1]  [t(1;8)(p31;q24)]  
Fusion : MitelmanNEXN/AK5 [1p31.1/1p31.1]  [t(1;1)(p31;p31)]  
Fusion: TCGAABCD3 1p21.3 AK5 1p31.1 LUSC
Fusion: TCGAFAM49B 8q24.21 AK5 1p31.1 BLCA
Fusion: TCGALPHN2 AK5 1p31.1 PRAD
Fusion: TCGANEXN 1p31.1 AK5 1p31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AK5
dbVarAK5
ClinVarAK5
1000_GenomesAK5 
Exome Variant ServerAK5
ExAC (Exome Aggregation Consortium)AK5 (select the gene name)
Genetic variants : HAPMAP26289
Genomic Variants (DGV)AK5 [DGVbeta]
DECIPHER (Syndromes)1:77748287-78025654  ENSG00000154027
CONAN: Copy Number AnalysisAK5 
Mutations
ICGC Data PortalAK5 
TCGA Data PortalAK5 
Broad Tumor PortalAK5
OASIS PortalAK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AK5
DgiDB (Drug Gene Interaction Database)AK5
DoCM (Curated mutations)AK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AK5 (select a term)
intoGenAK5
Cancer3DAK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608009   
Orphanet
MedgenAK5
Genetic Testing Registry AK5
NextProtQ9Y6K8 [Medical]
TSGene26289
GENETestsAK5
Huge Navigator AK5 [HugePedia]
snp3D : Map Gene to Disease26289
BioCentury BCIQAK5
ClinGenAK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26289
Chemical/Pharm GKB GenePA24659
Clinical trialAK5
Miscellaneous
canSAR (ICR)AK5 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAK5
EVEXAK5
GoPubMedAK5
iHOPAK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:55:23 CET 2017

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