Atlas of Genetics and Cytogenetics in Oncology and Haematology

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AK9 (adenylate kinase 9)

Identity

Alias (NCBI)AK 9
AKD1
AKD2
C6orf199
C6orf224
dJ70A9.1
HGNC (Hugo) AK9
HGNC Alias symbFLJ42177
FLJ25791
dJ70A9.1
MGC26954
HGNC Previous nameC6orf224
 AKD2
 C6orf199
 AKD1
HGNC Previous namechromosome 6 open reading frame 224
 adenylate kinase domain containing 2
 chromosome 6 open reading frame 199
 adenylate kinase domain containing 1
LocusID (NCBI) 221264
Atlas_Id 60222
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 109631696 and ends at 109691212 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AK9 (6q21) / FAM184A (6q22.31)HDAC2 (6q21) / AK9 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q21;q22) AK9/FAM184A

External links

Nomenclature
HGNC (Hugo)AK9   33814
Cards
Entrez_Gene (NCBI)AK9  221264  adenylate kinase 9
AliasesAK; AKD1; AKD2; C6orf199; 
C6orf224; dJ70A9.1
GeneCards (Weizmann)AK9
Ensembl hg19 (Hinxton)ENSG00000155085 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155085 [Gene_View]  ENSG00000155085 [Sequence]  chr6:109631696-109691212 [Contig_View]  AK9 [Vega]
ICGC DataPortalENSG00000155085
TCGA cBioPortalAK9
AceView (NCBI)AK9
Genatlas (Paris)AK9
WikiGenes221264
SOURCE (Princeton)AK9
Genetics Home Reference (NIH)AK9
Genomic and cartography
GoldenPath hg38 (UCSC)AK9  -     chr6:109631696-109691212 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AK9  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathAK9 - 6q21 [CytoView hg19]  AK9 - 6q21 [CytoView hg38]
ImmunoBaseENSG00000155085
genome Data Viewer NCBIAK9 [Mapview hg19]  
OMIM615358   
Gene and transcription
Genbank (Entrez)AK055538 AK098657 AK124171 AK131244 AK315561
RefSeq transcript (Entrez)NM_001001706 NM_001145128 NM_001329602 NM_001329603 NM_145025 NM_173559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AK9
Alternative Splicing GalleryENSG00000155085
Gene ExpressionAK9 [ NCBI-GEO ]   AK9 [ EBI - ARRAY_EXPRESS ]   AK9 [ SEEK ]   AK9 [ MEM ]
Gene Expression Viewer (FireBrowse)AK9 [ Firebrowse - Broad ]
GenevisibleExpression of AK9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221264
GTEX Portal (Tissue expression)AK9
Human Protein AtlasENSG00000155085-AK9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TCS8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TCS8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TCS8
Splice isoforms : SwissVarQ5TCS8
Catalytic activity : Enzyme2.7.4.4 [ Enzyme-Expasy ]   2.7.4.42.7.4.4 [ IntEnz-EBI ]   2.7.4.4 [ BRENDA ]   2.7.4.4 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5TCS8
Domains : Interpro (EBI)AAA+_ATPase    Adenylat/UMP-CMP_kin    P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)AK9
DMDM Disease mutations221264
Blocks (Seattle)AK9
SuperfamilyQ5TCS8
Human Protein Atlas [tissue]ENSG00000155085-AK9 [tissue]
Peptide AtlasQ5TCS8
HPRD12871
IPIIPI00556253   IPI00641136   IPI00856053   IPI00930224   IPI00418605   IPI00552962   IPI00947244   IPI00645506   IPI01025814   IPI00983239   IPI00984080   
Protein Interaction databases
DIP (DOE-UCLA)Q5TCS8
IntAct (EBI)Q5TCS8
FunCoupENSG00000155085
BioGRIDAK9
STRING (EMBL)AK9
ZODIACAK9
Ontologies - Pathways
QuickGOQ5TCS8
Ontology : AmiGOnucleoside diphosphate kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  dADP phosphorylation  dGDP phosphorylation  AMP phosphorylation  ATP generation from ADP  nucleobase-containing small molecule interconversion  nuclear membrane  nucleoside monophosphate kinase activity  CDP phosphorylation  dAMP phosphorylation  CMP phosphorylation  dCMP phosphorylation  GDP phosphorylation  UDP phosphorylation  dCDP phosphorylation  TDP phosphorylation  
Ontology : EGO-EBInucleoside diphosphate kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  dADP phosphorylation  dGDP phosphorylation  AMP phosphorylation  ATP generation from ADP  nucleobase-containing small molecule interconversion  nuclear membrane  nucleoside monophosphate kinase activity  CDP phosphorylation  dAMP phosphorylation  CMP phosphorylation  dCMP phosphorylation  GDP phosphorylation  UDP phosphorylation  dCDP phosphorylation  TDP phosphorylation  
NDEx NetworkAK9
Atlas of Cancer Signalling NetworkAK9
Wikipedia pathwaysAK9
Orthology - Evolution
OrthoDB221264
GeneTree (enSembl)ENSG00000155085
Phylogenetic Trees/Animal Genes : TreeFamAK9
HOGENOMQ5TCS8
Homologs : HomoloGeneAK9
Homology/Alignments : Family Browser (UCSC)AK9
Gene fusions - Rearrangements
Fusion : QuiverAK9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAK9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AK9
dbVarAK9
ClinVarAK9
1000_GenomesAK9 
Exome Variant ServerAK9
GNOMAD BrowserENSG00000155085
Varsome BrowserAK9
Genetic variants : HAPMAP221264
Genomic Variants (DGV)AK9 [DGVbeta]
DECIPHERAK9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAK9 
Mutations
ICGC Data PortalAK9 
TCGA Data PortalAK9 
Broad Tumor PortalAK9
OASIS PortalAK9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAK9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAK9
Mutations and Diseases : HGMDAK9
BioMutasearch AK9
DgiDB (Drug Gene Interaction Database)AK9
DoCM (Curated mutations)AK9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AK9 (select a term)
intoGenAK9
Cancer3DAK9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615358   
Orphanet
DisGeNETAK9
MedgenAK9
Genetic Testing Registry AK9
NextProtQ5TCS8 [Medical]
TSGene221264
GENETestsAK9
Target ValidationAK9
Huge Navigator AK9 [HugePedia]
snp3D : Map Gene to Disease221264
BioCentury BCIQAK9
ClinGenAK9
Clinical trials, drugs, therapy
Protein Interactions : CTD221264
Pharm GKB GenePA164715271
Clinical trialAK9
Miscellaneous
canSAR (ICR)AK9 (select the gene name)
HarmonizomeAK9
DataMed IndexAK9
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAK9
EVEXAK9
GoPubMedAK9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:05:21 CEST 2020
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