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AKAP10 (A-kinase anchoring protein 10)

Identity

Alias_namesA kinase (PRKA) anchor protein 10
Alias_symbol (synonym)D-AKAP2
PRKA10
MGC9414
Other aliasAKAP-10
D-AKAP-2
HGNC (Hugo) AKAP10
LocusID (NCBI) 11216
Atlas_Id 77
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 19807765 and ends at 19881169 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKAP10 (17p11.2) / AKAP10 (17p11.2)AKAP10 (17p11.2) / PSMD11 (17q11.2)CCNY (10p11.21) / AKAP10 (17p11.2)
EPN2 (17p11.2) / AKAP10 (17p11.2)RIMS4 (20q13.12) / AKAP10 (17p11.2)SMCHD1 (18p11.32) / AKAP10 (17p11.2)
CCNY 10p11.21 / AKAP10 17p11.2EPN2 17p11.2 / AKAP10 17p11.2RIMS4 20q13.12 / AKAP10 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Thyroid: Papillary carcinoma/Adenocarcinoma
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)AKAP10   368
Cards
Entrez_Gene (NCBI)AKAP10  11216  A-kinase anchoring protein 10
AliasesAKAP-10; D-AKAP-2; D-AKAP2; PRKA10
GeneCards (Weizmann)AKAP10
Ensembl hg19 (Hinxton)ENSG00000108599 [Gene_View]  chr17:19807765-19881169 [Contig_View]  AKAP10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108599 [Gene_View]  chr17:19807765-19881169 [Contig_View]  AKAP10 [Vega]
ICGC DataPortalENSG00000108599
TCGA cBioPortalAKAP10
AceView (NCBI)AKAP10
Genatlas (Paris)AKAP10
WikiGenes11216
SOURCE (Princeton)AKAP10
Genetics Home Reference (NIH)AKAP10
Genomic and cartography
GoldenPath hg19 (UCSC)AKAP10  -     chr17:19807765-19881169 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AKAP10  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblAKAP10 - 17p11.2 [CytoView hg19]  AKAP10 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIAKAP10 [Mapview hg19]  AKAP10 [Mapview hg38]
OMIM115080   604694   
Gene and transcription
Genbank (Entrez)AF037439 AK295180 AK308297 AK312438 BC017055
RefSeq transcript (Entrez)NM_007202
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_011493 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)AKAP10
Cluster EST : UnigeneHs.642676 [ NCBI ]
CGAP (NCI)Hs.642676
Alternative Splicing GalleryENSG00000108599
Gene ExpressionAKAP10 [ NCBI-GEO ]   AKAP10 [ EBI - ARRAY_EXPRESS ]   AKAP10 [ SEEK ]   AKAP10 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11216
GTEX Portal (Tissue expression)AKAP10
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43572   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43572  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43572
Splice isoforms : SwissVarO43572
PhosPhoSitePlusO43572
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)AKAP10
DMDM Disease mutations11216
Blocks (Seattle)AKAP10
PDB (SRS)3IM4    3TMH   
PDB (PDBSum)3IM4    3TMH   
PDB (IMB)3IM4    3TMH   
PDB (RSDB)3IM4    3TMH   
Structural Biology KnowledgeBase3IM4    3TMH   
SCOP (Structural Classification of Proteins)3IM4    3TMH   
CATH (Classification of proteins structures)3IM4    3TMH   
SuperfamilyO43572
Human Protein AtlasENSG00000108599
Peptide AtlasO43572
HPRD05259
IPIIPI00306265   IPI00657731   
Protein Interaction databases
DIP (DOE-UCLA)O43572
IntAct (EBI)O43572
FunCoupENSG00000108599
BioGRIDAKAP10
STRING (EMBL)AKAP10
ZODIACAKAP10
Ontologies - Pathways
QuickGOO43572
Ontology : AmiGOcytoplasm  mitochondrion  cytosol  plasma membrane  signal transduction  blood coagulation  protein localization  
Ontology : EGO-EBIcytoplasm  mitochondrion  cytosol  plasma membrane  signal transduction  blood coagulation  protein localization  
NDEx NetworkAKAP10
Atlas of Cancer Signalling NetworkAKAP10
Wikipedia pathwaysAKAP10
Orthology - Evolution
OrthoDB11216
GeneTree (enSembl)ENSG00000108599
Phylogenetic Trees/Animal Genes : TreeFamAKAP10
HOVERGENO43572
HOGENOMO43572
Homologs : HomoloGeneAKAP10
Homology/Alignments : Family Browser (UCSC)AKAP10
Gene fusions - Rearrangements
Fusion : MitelmanAKAP10/PSMD11 [17p11.2/17q11.2]  
Fusion : MitelmanCCNY/AKAP10 [10p11.21/17p11.2]  [t(10;17)(p11;p11)]  
Fusion : MitelmanEPN2/AKAP10 [17p11.2/17p11.2]  [t(17;17)(p11;p11)]  
Fusion : MitelmanRIMS4/AKAP10 [20q13.12/17p11.2]  [t(17;20)(p11;q13)]  
Fusion: TCGACCNY 10p11.21 AKAP10 17p11.2 BRCA
Fusion: TCGAEPN2 17p11.2 AKAP10 17p11.2 BRCA
Fusion: TCGARIMS4 20q13.12 AKAP10 17p11.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP10
dbVarAKAP10
ClinVarAKAP10
1000_GenomesAKAP10 
Exome Variant ServerAKAP10
ExAC (Exome Aggregation Consortium)AKAP10 (select the gene name)
Genetic variants : HAPMAP11216
Genomic Variants (DGV)AKAP10 [DGVbeta]
DECIPHER (Syndromes)17:19807765-19881169  ENSG00000108599
CONAN: Copy Number AnalysisAKAP10 
Mutations
ICGC Data PortalAKAP10 
TCGA Data PortalAKAP10 
Broad Tumor PortalAKAP10
OASIS PortalAKAP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AKAP10
DgiDB (Drug Gene Interaction Database)AKAP10
DoCM (Curated mutations)AKAP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP10 (select a term)
intoGenAKAP10
Cancer3DAKAP10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115080    604694   
Orphanet
MedgenAKAP10
Genetic Testing Registry AKAP10
NextProtO43572 [Medical]
TSGene11216
GENETestsAKAP10
Huge Navigator AKAP10 [HugePedia]
snp3D : Map Gene to Disease11216
BioCentury BCIQAKAP10
ClinGenAKAP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11216
Chemical/Pharm GKB GenePA24662
Clinical trialAKAP10
Miscellaneous
canSAR (ICR)AKAP10 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP10
EVEXAKAP10
GoPubMedAKAP10
iHOPAKAP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:24 CET 2017

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