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AKAP10 (A-kinase anchoring protein 10)

Identity

Alias (NCBI)AKAP-10
D-AKAP-2
D-AKAP2
PRKA10
HGNC (Hugo) AKAP10
HGNC Alias symbD-AKAP2
PRKA10
MGC9414
HGNC Alias namedual-specificity A-kinase anchoring protein 2
 protein kinase A anchoring protein 10
 mitochondrial A kinase PPKA anchor protein 10
HGNC Previous nameA kinase (PRKA) anchor protein 10
LocusID (NCBI) 11216
Atlas_Id 77
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 19904303 and ends at 19977828 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKAP10 (17p11.2) / AKAP10 (17p11.2)AKAP10 (17p11.2) / PSMD11 (17q11.2)CCNY (10p11.21) / AKAP10 (17p11.2)
EPN2 (17p11.2) / AKAP10 (17p11.2)RIMS4 (20q13.12) / AKAP10 (17p11.2)SMCHD1 (18p11.32) / AKAP10 (17p11.2)
CCNY 10p11.21 / AKAP10 17p11.2EPN2 17p11.2 / AKAP10 17p11.2RIMS4 20q13.12 / AKAP10 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AKAP10   368
Cards
Entrez_Gene (NCBI)AKAP10    A-kinase anchoring protein 10
AliasesAKAP-10; D-AKAP-2; D-AKAP2; PRKA10
GeneCards (Weizmann)AKAP10
Ensembl hg19 (Hinxton)ENSG00000108599 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108599 [Gene_View]  ENSG00000108599 [Sequence]  chr17:19904303-19977828 [Contig_View]  AKAP10 [Vega]
ICGC DataPortalENSG00000108599
TCGA cBioPortalAKAP10
AceView (NCBI)AKAP10
Genatlas (Paris)AKAP10
SOURCE (Princeton)AKAP10
Genetics Home Reference (NIH)AKAP10
Genomic and cartography
GoldenPath hg38 (UCSC)AKAP10  -     chr17:19904303-19977828 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKAP10  -     17p11.2   [Description]    (hg19-Feb_2009)
GoldenPathAKAP10 - 17p11.2 [CytoView hg19]  AKAP10 - 17p11.2 [CytoView hg38]
ImmunoBaseENSG00000108599
Genome Data Viewer NCBIAKAP10 [Mapview hg19]  
OMIM115080   604694   
Gene and transcription
Genbank (Entrez)AF037439 AK295180 AK308297 AK312438 BC017055
RefSeq transcript (Entrez)NM_001330152 NM_007202
Consensus coding sequences : CCDS (NCBI)AKAP10
Gene ExpressionAKAP10 [ NCBI-GEO ]   AKAP10 [ EBI - ARRAY_EXPRESS ]   AKAP10 [ SEEK ]   AKAP10 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP10 [ Firebrowse - Broad ]
GenevisibleExpression of AKAP10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11216
GTEX Portal (Tissue expression)AKAP10
Human Protein AtlasENSG00000108599-AKAP10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43572   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43572  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43572
PhosPhoSitePlusO43572
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)AKAP10_AKB_dom    RGS    RGS_sf   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)AKAP10
PDB (RSDB)3IM4    3TMH   
PDB Europe3IM4    3TMH   
PDB (PDBSum)3IM4    3TMH   
PDB (IMB)3IM4    3TMH   
Structural Biology KnowledgeBase3IM4    3TMH   
SCOP (Structural Classification of Proteins)3IM4    3TMH   
CATH (Classification of proteins structures)3IM4    3TMH   
SuperfamilyO43572
AlphaFold pdb e-kbO43572   
Human Protein Atlas [tissue]ENSG00000108599-AKAP10 [tissue]
HPRD05259
Protein Interaction databases
DIP (DOE-UCLA)O43572
IntAct (EBI)O43572
BioGRIDAKAP10
STRING (EMBL)AKAP10
ZODIACAKAP10
Ontologies - Pathways
QuickGOO43572
Ontology : AmiGOprotein binding  mitochondrion  cytosol  cytosol  plasma membrane  plasma membrane  signal transduction  blood coagulation  protein localization  protein-containing complex  protein kinase A binding  
Ontology : EGO-EBIprotein binding  mitochondrion  cytosol  cytosol  plasma membrane  plasma membrane  signal transduction  blood coagulation  protein localization  protein-containing complex  protein kinase A binding  
NDEx NetworkAKAP10
Atlas of Cancer Signalling NetworkAKAP10
Wikipedia pathwaysAKAP10
Orthology - Evolution
OrthoDB11216
GeneTree (enSembl)ENSG00000108599
Phylogenetic Trees/Animal Genes : TreeFamAKAP10
Homologs : HomoloGeneAKAP10
Homology/Alignments : Family Browser (UCSC)AKAP10
Gene fusions - Rearrangements
Fusion : MitelmanAKAP10/PSMD11 [17p11.2/17q11.2]  
Fusion : MitelmanCCNY/AKAP10 [10p11.21/17p11.2]  
Fusion : MitelmanEPN2/AKAP10 [17p11.2/17p11.2]  
Fusion : MitelmanRIMS4/AKAP10 [20q13.12/17p11.2]  
Fusion : QuiverAKAP10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP10
dbVarAKAP10
ClinVarAKAP10
MonarchAKAP10
1000_GenomesAKAP10 
Exome Variant ServerAKAP10
GNOMAD BrowserENSG00000108599
Varsome BrowserAKAP10
ACMGAKAP10 variants
VarityO43572
Genomic Variants (DGV)AKAP10 [DGVbeta]
DECIPHERAKAP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKAP10 
Mutations
ICGC Data PortalAKAP10 
TCGA Data PortalAKAP10 
Broad Tumor PortalAKAP10
OASIS PortalAKAP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAKAP10
Mutations and Diseases : HGMDAKAP10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAKAP10
DgiDB (Drug Gene Interaction Database)AKAP10
DoCM (Curated mutations)AKAP10
CIViC (Clinical Interpretations of Variants in Cancer)AKAP10
Cancer3DAKAP10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115080    604694   
Orphanet
DisGeNETAKAP10
MedgenAKAP10
Genetic Testing Registry AKAP10
NextProtO43572 [Medical]
GENETestsAKAP10
Target ValidationAKAP10
Huge Navigator AKAP10 [HugePedia]
ClinGenAKAP10
Clinical trials, drugs, therapy
MyCancerGenomeAKAP10
Protein Interactions : CTDAKAP10
Pharm GKB GenePA24662
PharosO43572
Clinical trialAKAP10
Miscellaneous
canSAR (ICR)AKAP10
HarmonizomeAKAP10
DataMed IndexAKAP10
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAKAP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:58 CEST 2021

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