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AKAP13 (A kinase (PRKA) anchor protein 13)

Identity

Other namesAKAP-13
AKAP-Lbc
ARHGEF13
BRX
HA-3
Ht31
LBC
PRKA13
PROTO-LB
PROTO-LBC
c-lbc
p47
HGNC (Hugo) AKAP13
LocusID (NCBI) 11214
Location 15q25.3
Location_base_pair Starts at 86163181 and ends at 86292589 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AKAP13   371
Cards
Entrez_Gene (NCBI)AKAP13  11214  A kinase (PRKA) anchor protein 13
GeneCards (Weizmann)AKAP13
Ensembl (Hinxton)ENSG00000170776 [Gene_View]  chr15:86163181-86292589 [Contig_View]  AKAP13 [Vega]
ICGC DataPortalENSG00000170776
AceView (NCBI)AKAP13
Genatlas (Paris)AKAP13
WikiGenes11214
SOURCE (Princeton)NM_001270546 NM_006738 NM_007200 NM_144767
Genomic and cartography
GoldenPath (UCSC)AKAP13  -  15q25.3   chr15:86163181-86292589 +  15q25.3   [Description]    (hg19-Feb_2009)
EnsemblAKAP13 - 15q25.3 [CytoView]
Mapping of homologs : NCBIAKAP13 [Mapview]
OMIM604686   
Gene and transcription
Genbank (Entrez)AB055890 AB209414 AF086293 AF126008 AF387101
RefSeq transcript (Entrez)NM_001270546 NM_006738 NM_007200 NM_144767
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838222 NW_004929399
Consensus coding sequences : CCDS (NCBI)AKAP13
Cluster EST : UnigeneHs.710656 [ NCBI ]
CGAP (NCI)Hs.710656
Alternative Splicing : Fast-db (Paris)GSHG0022772
Alternative Splicing GalleryENSG00000170776
Gene ExpressionAKAP13 [ NCBI-GEO ]     AKAP13 [ SEEK ]   AKAP13 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12802 (Uniprot)
NextProtQ12802  [Medical]
With graphics : InterProQ12802
Splice isoforms : SwissVarQ12802 (Swissvar)
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AKAP13    DH-domain    PH_like_dom    Pleckstrin_homology    Prot_Kinase_C-like_PE/DAG-bd   
Related proteins : CluSTrQ12802
Domain families : Pfam (Sanger)PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00169    pfam00621   
Domain families : Smart (EMBL)C1 (SM00109)  PH (SM00233)  RhoGEF (SM00325)  
DMDM Disease mutations11214
Blocks (Seattle)Q12802
PDB (SRS)2DRN    2LG1   
PDB (PDBSum)2DRN    2LG1   
PDB (IMB)2DRN    2LG1   
PDB (RSDB)2DRN    2LG1   
Human Protein AtlasENSG00000170776
Peptide AtlasQ12802
HPRD05253
IPIIPI00329783   IPI00065931   IPI00829717   IPI00829774   IPI00384381   IPI00829853   IPI00885071   IPI01018636   IPI00872432   IPI00375281   
Protein Interaction databases
DIP (DOE-UCLA)Q12802
IntAct (EBI)Q12802
FunCoupENSG00000170776
BioGRIDAKAP13
InParanoidQ12802
Interologous Interaction database Q12802
IntegromeDBAKAP13
STRING (EMBL)AKAP13
Ontologies - Pathways
Ontology : AmiGOcAMP-dependent protein kinase activity  signal transducer activity  Rho guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  cytosol  protein phosphorylation  protein phosphorylation  small GTPase mediated signal transduction  regulation of cardiac muscle hypertrophy  membrane  Rho GTPase binding  positive regulation of Rho GTPase activity  protein complex scaffold  positive regulation of apoptotic process  regulation of protein kinase activity  metal ion binding  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  protein kinase A binding  regulation of small GTPase mediated signal transduction  nuclear export  apoptotic signaling pathway  regulation of glucocorticoid mediated signaling pathway  
Ontology : EGO-EBIcAMP-dependent protein kinase activity  signal transducer activity  Rho guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  cytosol  protein phosphorylation  protein phosphorylation  small GTPase mediated signal transduction  regulation of cardiac muscle hypertrophy  membrane  Rho GTPase binding  positive regulation of Rho GTPase activity  protein complex scaffold  positive regulation of apoptotic process  regulation of protein kinase activity  metal ion binding  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  protein kinase A binding  regulation of small GTPase mediated signal transduction  nuclear export  apoptotic signaling pathway  regulation of glucocorticoid mediated signaling pathway  
Pathways : BIOCARTARho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation [Genes]   
Protein Interaction DatabaseAKAP13
Wikipedia pathwaysAKAP13
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)AKAP13
SNP (GeneSNP Utah)AKAP13
SNP : HGBaseAKAP13
Genetic variants : HAPMAPAKAP13
1000_GenomesAKAP13 
ICGC programENSG00000170776 
CONAN: Copy Number AnalysisAKAP13 
Somatic Mutations in Cancer : COSMICAKAP13 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDAKAP13
OMIM604686   
MedgenAKAP13
GENETestsAKAP13
Disease Genetic AssociationAKAP13
Huge Navigator AKAP13 [HugePedia]  AKAP13 [HugeCancerGEM]
Genomic VariantsAKAP13  AKAP13 [DGVbeta]
Exome VariantAKAP13
dbVarAKAP13
ClinVarAKAP13
snp3D : Map Gene to Disease11214
General knowledge
Homologs : HomoloGeneAKAP13
Homology/Alignments : Family Browser (UCSC)AKAP13
Phylogenetic Trees/Animal Genes : TreeFamAKAP13
Chemical/Protein Interactions : CTD11214
Chemical/Pharm GKB GenePA24665
Clinical trialAKAP13
Cancer Resource (Charite)ENSG00000170776
Other databases
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
CoreMineAKAP13
iHOPAKAP13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:31:24 CEST 2014

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