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AKAP2 (A-kinase anchoring protein 2)

Identity

Alias_namesPRKA2
A kinase (PRKA) anchor protein 2
Alias_symbol (synonym)AKAP-KL
KIAA0920
DKFZp564L0716
MISP2
Other aliasAKAP-2
AKAPKL
HGNC (Hugo) AKAP2
LocusID (NCBI) 11217
Atlas_Id 54113
Location 9q31.3  [Link to chromosome band 9q31]
Location_base_pair Starts at 110048598 and ends at 110172511 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKAP2 (9q31.3) / ACTG1 (17q25.3)AKAP2 (9q31.3) / AKAP2 (9q31.3)AKAP2 (9q31.3) / NR4A1 (12q13.13)
AKAP2 (9q31.3) / ZFAND3 (6p21.2)IGF2R (6q25.3) / AKAP2 (9q31.3)LOC100507412 (-) / AKAP2 (9q31.3)
PALM2 (9q31.3) / AKAP2 (9q31.3)THBS1 (15q14) / AKAP2 (9q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKAP2   372
Cards
Entrez_Gene (NCBI)AKAP2  11217  A-kinase anchoring protein 2
AliasesAKAP-2; AKAPKL; MISP2; PRKA2
GeneCards (Weizmann)AKAP2
Ensembl hg19 (Hinxton)ENSG00000241978 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241978 [Gene_View]  chr9:110048598-110172511 [Contig_View]  AKAP2 [Vega]
ICGC DataPortalENSG00000241978
TCGA cBioPortalAKAP2
AceView (NCBI)AKAP2
Genatlas (Paris)AKAP2
WikiGenes11217
SOURCE (Princeton)AKAP2
Genetics Home Reference (NIH)AKAP2
Genomic and cartography
GoldenPath hg38 (UCSC)AKAP2  -     chr9:110048598-110172511 +  9q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKAP2  -     9q31.3   [Description]    (hg19-Feb_2009)
EnsemblAKAP2 - 9q31.3 [CytoView hg19]  AKAP2 - 9q31.3 [CytoView hg38]
Mapping of homologs : NCBIAKAP2 [Mapview hg19]  AKAP2 [Mapview hg38]
OMIM604582   
Gene and transcription
Genbank (Entrez)AJ420463 AK000306 AK022693 AK057098 AK300427
RefSeq transcript (Entrez)NM_001004065 NM_001136562 NM_001198656
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKAP2
Cluster EST : UnigeneHs.591908 [ NCBI ]
CGAP (NCI)Hs.591908
Alternative Splicing GalleryENSG00000241978
Gene ExpressionAKAP2 [ NCBI-GEO ]   AKAP2 [ EBI - ARRAY_EXPRESS ]   AKAP2 [ SEEK ]   AKAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11217
GTEX Portal (Tissue expression)AKAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2D5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2D5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2D5
Splice isoforms : SwissVarQ9Y2D5
PhosPhoSitePlusQ9Y2D5
Domains : Interpro (EBI)AKAP2_C   
Domain families : Pfam (Sanger)AKAP2_C (PF15304)   
Domain families : Pfam (NCBI)pfam15304   
Conserved Domain (NCBI)AKAP2
DMDM Disease mutations11217
Blocks (Seattle)AKAP2
SuperfamilyQ9Y2D5
Human Protein AtlasENSG00000241978
Peptide AtlasQ9Y2D5
IPIIPI00032064   IPI00816415   IPI00073769   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2D5
IntAct (EBI)Q9Y2D5
FunCoupENSG00000241978
BioGRIDAKAP2
STRING (EMBL)AKAP2
ZODIACAKAP2
Ontologies - Pathways
QuickGOQ9Y2D5
Ontology : AmiGOactin filament organization  transmembrane receptor protein serine/threonine kinase signaling pathway  protein localization  protein kinase A binding  
Ontology : EGO-EBIactin filament organization  transmembrane receptor protein serine/threonine kinase signaling pathway  protein localization  protein kinase A binding  
NDEx NetworkAKAP2
Atlas of Cancer Signalling NetworkAKAP2
Wikipedia pathwaysAKAP2
Orthology - Evolution
OrthoDB11217
GeneTree (enSembl)ENSG00000241978
Phylogenetic Trees/Animal Genes : TreeFamAKAP2
HOVERGENQ9Y2D5
HOGENOMQ9Y2D5
Homologs : HomoloGeneAKAP2
Homology/Alignments : Family Browser (UCSC)AKAP2
Gene fusions - Rearrangements
Fusion : MitelmanPALM2/AKAP2 [9q31.3/9q31.3]  [t(9;9)(q31;q31)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP2
dbVarAKAP2
ClinVarAKAP2
1000_GenomesAKAP2 
Exome Variant ServerAKAP2
ExAC (Exome Aggregation Consortium)AKAP2 (select the gene name)
Genetic variants : HAPMAP11217
Genomic Variants (DGV)AKAP2 [DGVbeta]
DECIPHERAKAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKAP2 
Mutations
ICGC Data PortalAKAP2 
TCGA Data PortalAKAP2 
Broad Tumor PortalAKAP2
OASIS PortalAKAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKAP2
DgiDB (Drug Gene Interaction Database)AKAP2
DoCM (Curated mutations)AKAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP2 (select a term)
intoGenAKAP2
Cancer3DAKAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604582   
Orphanet
MedgenAKAP2
Genetic Testing Registry AKAP2
NextProtQ9Y2D5 [Medical]
TSGene11217
GENETestsAKAP2
Huge Navigator AKAP2 [HugePedia]
snp3D : Map Gene to Disease11217
BioCentury BCIQAKAP2
ClinGenAKAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11217
Chemical/Pharm GKB GenePA24666
Clinical trialAKAP2
Miscellaneous
canSAR (ICR)AKAP2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP2
EVEXAKAP2
GoPubMedAKAP2
iHOPAKAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:33 CEST 2017

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