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AKAP3 (A-kinase anchoring protein 3)

Identity

Alias_namesA kinase (PRKA) anchor protein 3
Alias_symbol (synonym)FSP95
SOB1
AKAP110
CT82
Other aliasAKAP 110
HEL159
PRKA3
HGNC (Hugo) AKAP3
LocusID (NCBI) 10566
Atlas_Id 45668
Location 12p13.32  [Link to chromosome band 12p13]
Location_base_pair Starts at 4724674 and ends at 4758213 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKAP3 (12p13.32) / AKAP3 (12p13.32)CCND2 (12p13.32) / AKAP3 (12p13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKAP3   373
Cards
Entrez_Gene (NCBI)AKAP3  10566  A-kinase anchoring protein 3
AliasesAKAP; AKAP110; CT82; FSP95; 
HEL159; PRKA3; SOB1
GeneCards (Weizmann)AKAP3
Ensembl hg19 (Hinxton)ENSG00000111254 [Gene_View]  chr12:4724674-4758213 [Contig_View]  AKAP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111254 [Gene_View]  chr12:4724674-4758213 [Contig_View]  AKAP3 [Vega]
ICGC DataPortalENSG00000111254
TCGA cBioPortalAKAP3
AceView (NCBI)AKAP3
Genatlas (Paris)AKAP3
WikiGenes10566
SOURCE (Princeton)AKAP3
Genetics Home Reference (NIH)AKAP3
Genomic and cartography
GoldenPath hg19 (UCSC)AKAP3  -     chr12:4724674-4758213 -  12p13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AKAP3  -     12p13.32   [Description]    (hg38-Dec_2013)
EnsemblAKAP3 - 12p13.32 [CytoView hg19]  AKAP3 - 12p13.32 [CytoView hg38]
Mapping of homologs : NCBIAKAP3 [Mapview hg19]  AKAP3 [Mapview hg38]
OMIM604689   
Gene and transcription
Genbank (Entrez)AF087003 AF093408 AI004486 AK074722 AK292451
RefSeq transcript (Entrez)NM_001278309 NM_006422
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)AKAP3
Cluster EST : UnigeneHs.98397 [ NCBI ]
CGAP (NCI)Hs.98397
Alternative Splicing GalleryENSG00000111254
Gene ExpressionAKAP3 [ NCBI-GEO ]   AKAP3 [ EBI - ARRAY_EXPRESS ]   AKAP3 [ SEEK ]   AKAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10566
GTEX Portal (Tissue expression)AKAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75969   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75969  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75969
Splice isoforms : SwissVarO75969
PhosPhoSitePlusO75969
Domains : Interpro (EBI)AKAP_110    AKAP_110_C    RII_binding_1    SPHK1-interactor_AKAP_110   
Domain families : Pfam (Sanger)AKAP_110 (PF05716)    RII_binding_1 (PF10522)   
Domain families : Pfam (NCBI)pfam05716    pfam10522   
Domain families : Smart (EMBL)AKAP_110 (SM00807)  
Conserved Domain (NCBI)AKAP3
DMDM Disease mutations10566
Blocks (Seattle)AKAP3
SuperfamilyO75969
Human Protein AtlasENSG00000111254
Peptide AtlasO75969
HPRD05256
IPIIPI00290854   IPI01013921   IPI01012478   
Protein Interaction databases
DIP (DOE-UCLA)O75969
IntAct (EBI)O75969
FunCoupENSG00000111254
BioGRIDAKAP3
STRING (EMBL)AKAP3
ZODIACAKAP3
Ontologies - Pathways
QuickGOO75969
Ontology : AmiGOacrosomal vesicle  protein binding  nucleus  cytoplasm  movement of cell or subcellular component  transmembrane receptor protein serine/threonine kinase signaling pathway  single fertilization  acrosome reaction  protein localization  regulation of protein kinase A signaling  sperm fibrous sheath  protein kinase A binding  sperm principal piece  
Ontology : EGO-EBIacrosomal vesicle  protein binding  nucleus  cytoplasm  movement of cell or subcellular component  transmembrane receptor protein serine/threonine kinase signaling pathway  single fertilization  acrosome reaction  protein localization  regulation of protein kinase A signaling  sperm fibrous sheath  protein kinase A binding  sperm principal piece  
NDEx NetworkAKAP3
Atlas of Cancer Signalling NetworkAKAP3
Wikipedia pathwaysAKAP3
Orthology - Evolution
OrthoDB10566
GeneTree (enSembl)ENSG00000111254
Phylogenetic Trees/Animal Genes : TreeFamAKAP3
HOVERGENO75969
HOGENOMO75969
Homologs : HomoloGeneAKAP3
Homology/Alignments : Family Browser (UCSC)AKAP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP3
dbVarAKAP3
ClinVarAKAP3
1000_GenomesAKAP3 
Exome Variant ServerAKAP3
ExAC (Exome Aggregation Consortium)AKAP3 (select the gene name)
Genetic variants : HAPMAP10566
Genomic Variants (DGV)AKAP3 [DGVbeta]
DECIPHER (Syndromes)12:4724674-4758213  ENSG00000111254
CONAN: Copy Number AnalysisAKAP3 
Mutations
ICGC Data PortalAKAP3 
TCGA Data PortalAKAP3 
Broad Tumor PortalAKAP3
OASIS PortalAKAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKAP3
DgiDB (Drug Gene Interaction Database)AKAP3
DoCM (Curated mutations)AKAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP3 (select a term)
intoGenAKAP3
Cancer3DAKAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604689   
Orphanet
MedgenAKAP3
Genetic Testing Registry AKAP3
NextProtO75969 [Medical]
TSGene10566
GENETestsAKAP3
Huge Navigator AKAP3 [HugePedia]
snp3D : Map Gene to Disease10566
BioCentury BCIQAKAP3
ClinGenAKAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10566
Chemical/Pharm GKB GenePA24667
Clinical trialAKAP3
Miscellaneous
canSAR (ICR)AKAP3 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP3
EVEXAKAP3
GoPubMedAKAP3
iHOPAKAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:24 CET 2017

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