AKAP5 (A-kinase anchoring protein 5)

2007-04-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
AKAP75,AKAP79,H21

Other Information

Locus ID:

NCBI: 9495
MIM: 604688
HGNC: 375
Ensembl: ENSG00000179841

Variants:

dbSNP: 9495
ClinVar: 9495
TCGA: ENSG00000179841
COSMIC: AKAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179841ENST00000320636P24588
ENSG00000179841ENST00000394718P24588

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169734432006Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.99
223437222012Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.67
125079942003Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy.60
226236572012Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.55
121145072002Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79.53
214642872011Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex.44
169400532006AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor.42
217717832011Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.38
204103032010AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.34
183051162008AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site.32

Citation

Dessen P

AKAP5 (A-kinase anchoring protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47463/akap5