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AKAP7 (A-kinase anchoring protein 7)

Identity

Alias_namesA kinase (PRKA) anchor protein 7
Alias_symbol (synonym)AKAP18
AKAP15
Other alias
HGNC (Hugo) AKAP7
LocusID (NCBI) 9465
Atlas_Id 46846
Location 6q23.2  [Link to chromosome band 6q23]
Location_base_pair Starts at 131250159 and ends at 131283535 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKAP7 (6q23.2) / AKAP7 (6q23.2)VPS13B (8q22.2) / AKAP7 (6q23.2)VPS13B 8q22.2 / AKAP7 6q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;8)(q23;q22) VPS13B/AKAP7


External links

Nomenclature
HGNC (Hugo)AKAP7   377
Cards
Entrez_Gene (NCBI)AKAP7  9465  A-kinase anchoring protein 7
AliasesAKAP15; AKAP18
GeneCards (Weizmann)AKAP7
Ensembl hg19 (Hinxton)ENSG00000118507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118507 [Gene_View]  ENSG00000118507 [Sequence]  chr6:131250159-131283535 [Contig_View]  AKAP7 [Vega]
ICGC DataPortalENSG00000118507
TCGA cBioPortalAKAP7
AceView (NCBI)AKAP7
Genatlas (Paris)AKAP7
WikiGenes9465
SOURCE (Princeton)AKAP7
Genetics Home Reference (NIH)AKAP7
Genomic and cartography
GoldenPath hg38 (UCSC)AKAP7  -     chr6:131250159-131283535 +  6q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKAP7  -     6q23.2   [Description]    (hg19-Feb_2009)
EnsemblAKAP7 - 6q23.2 [CytoView hg19]  AKAP7 - 6q23.2 [CytoView hg38]
Mapping of homologs : NCBIAKAP7 [Mapview hg19]  AKAP7 [Mapview hg38]
OMIM604693   
Gene and transcription
Genbank (Entrez)AB451273 AB451400 AF152929 AF161075 AK290271
RefSeq transcript (Entrez)NM_004842 NM_016377 NM_138633
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKAP7
Cluster EST : UnigeneHs.732515 [ NCBI ]
CGAP (NCI)Hs.732515
Alternative Splicing GalleryENSG00000118507
Gene ExpressionAKAP7 [ NCBI-GEO ]   AKAP7 [ EBI - ARRAY_EXPRESS ]   AKAP7 [ SEEK ]   AKAP7 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9465
GTEX Portal (Tissue expression)AKAP7
Human Protein AtlasENSG00000118507-AKAP7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0M2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0M2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0M2
Splice isoforms : SwissVarQ9P0M2
PhosPhoSitePlusQ9P0M2
Domains : Interpro (EBI)AKAP7_RI-RII-bd_dom    cNuc_Pdiesterase    Kinase-A_anchor_nucl_local_sig   
Domain families : Pfam (Sanger)AKAP7_NLS (PF10469)    AKAP7_RIRII_bdg (PF10470)   
Domain families : Pfam (NCBI)pfam10469    pfam10470   
Conserved Domain (NCBI)AKAP7
DMDM Disease mutations9465
Blocks (Seattle)AKAP7
PDB (SRS)4ZP3    5JJ2   
PDB (PDBSum)4ZP3    5JJ2   
PDB (IMB)4ZP3    5JJ2   
PDB (RSDB)4ZP3    5JJ2   
Structural Biology KnowledgeBase4ZP3    5JJ2   
SCOP (Structural Classification of Proteins)4ZP3    5JJ2   
CATH (Classification of proteins structures)4ZP3    5JJ2   
SuperfamilyQ9P0M2
Human Protein Atlas [tissue]ENSG00000118507-AKAP7 [tissue]
Peptide AtlasQ9P0M2
HPRD16065
IPIIPI00216352   IPI00171649   IPI00942176   IPI00422254   IPI01009675   IPI01010609   IPI01009805   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0M2
IntAct (EBI)Q9P0M2
FunCoupENSG00000118507
BioGRIDAKAP7
STRING (EMBL)AKAP7
ZODIACAKAP7
Ontologies - Pathways
QuickGOQ9P0M2
Ontology : AmiGOnucleotide binding  protein binding  nucleus  cytosol  cytosol  biological_process  regulation of protein kinase A signaling  protein kinase binding  protein-containing complex  protein kinase A regulatory subunit binding  protein kinase A binding  protein kinase A binding  
Ontology : EGO-EBInucleotide binding  protein binding  nucleus  cytosol  cytosol  biological_process  regulation of protein kinase A signaling  protein kinase binding  protein-containing complex  protein kinase A regulatory subunit binding  protein kinase A binding  protein kinase A binding  
NDEx NetworkAKAP7
Atlas of Cancer Signalling NetworkAKAP7
Wikipedia pathwaysAKAP7
Orthology - Evolution
OrthoDB9465
GeneTree (enSembl)ENSG00000118507
Phylogenetic Trees/Animal Genes : TreeFamAKAP7
HOVERGENQ9P0M2
HOGENOMQ9P0M2
Homologs : HomoloGeneAKAP7
Homology/Alignments : Family Browser (UCSC)AKAP7
Gene fusions - Rearrangements
Fusion : MitelmanVPS13B/AKAP7 [8q22.2/6q23.2]  [t(6;8)(q23;q22)]  
Fusion PortalVPS13B 8q22.2 AKAP7 6q23.2 PRAD
Fusion : QuiverAKAP7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP7
dbVarAKAP7
ClinVarAKAP7
1000_GenomesAKAP7 
Exome Variant ServerAKAP7
ExAC (Exome Aggregation Consortium)ENSG00000118507
GNOMAD BrowserENSG00000118507
Varsome BrowserAKAP7
Genetic variants : HAPMAP9465
Genomic Variants (DGV)AKAP7 [DGVbeta]
DECIPHERAKAP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKAP7 
Mutations
ICGC Data PortalAKAP7 
TCGA Data PortalAKAP7 
Broad Tumor PortalAKAP7
OASIS PortalAKAP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKAP7
DgiDB (Drug Gene Interaction Database)AKAP7
DoCM (Curated mutations)AKAP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP7 (select a term)
intoGenAKAP7
Cancer3DAKAP7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604693   
Orphanet
DisGeNETAKAP7
MedgenAKAP7
Genetic Testing Registry AKAP7
NextProtQ9P0M2 [Medical]
TSGene9465
GENETestsAKAP7
Target ValidationAKAP7
Huge Navigator AKAP7 [HugePedia]
snp3D : Map Gene to Disease9465
BioCentury BCIQAKAP7
ClinGenAKAP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9465
Chemical/Pharm GKB GenePA24671
Clinical trialAKAP7
Miscellaneous
canSAR (ICR)AKAP7 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP7
EVEXAKAP7
GoPubMedAKAP7
iHOPAKAP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:08:30 CEST 2018

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