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AKAP8 (A-kinase anchoring protein 8)

Identity

Alias_names95kDa
Alias_symbol (synonym)AKAP95
DKFZp586B1222
Other aliasAKAP 95
AKAP-8
AKAP-95
HGNC (Hugo) AKAP8
LocusID (NCBI) 10270
Atlas_Id 609
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 15353521 and ends at 15379801 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADCK4 (19q13.2) / AKAP8 (19p13.12)AKAP8 (19p13.12) / AKAP8 (19p13.12)AKAP8 (19p13.12) / VMP1 (17q23.1)
AKAP8L (19p13.12) / AKAP8 (19p13.12)MTRNR2L8 (11p15.4) / AKAP8 (19p13.12)ADCK4 19q13.2 / AKAP8 19p13.12
AKAP8 19p13.12 / VMP1 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKAP8   378
Cards
Entrez_Gene (NCBI)AKAP8  10270  A-kinase anchoring protein 8
AliasesAKAP; AKAP-8; AKAP-95; AKAP95
GeneCards (Weizmann)AKAP8
Ensembl hg19 (Hinxton)ENSG00000105127 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105127 [Gene_View]  chr19:15353521-15379801 [Contig_View]  AKAP8 [Vega]
ICGC DataPortalENSG00000105127
TCGA cBioPortalAKAP8
AceView (NCBI)AKAP8
Genatlas (Paris)AKAP8
WikiGenes10270
SOURCE (Princeton)AKAP8
Genetics Home Reference (NIH)AKAP8
Genomic and cartography
GoldenPath hg38 (UCSC)AKAP8  -     chr19:15353521-15379801 -  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKAP8  -     19p13.12   [Description]    (hg19-Feb_2009)
EnsemblAKAP8 - 19p13.12 [CytoView hg19]  AKAP8 - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIAKAP8 [Mapview hg19]  AKAP8 [Mapview hg38]
OMIM604692   
Gene and transcription
Genbank (Entrez)AI581319 AK303640 AK308251 AK309529 AL050160
RefSeq transcript (Entrez)NM_005858
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKAP8
Cluster EST : UnigeneHs.594496 [ NCBI ]
CGAP (NCI)Hs.594496
Alternative Splicing GalleryENSG00000105127
Gene ExpressionAKAP8 [ NCBI-GEO ]   AKAP8 [ EBI - ARRAY_EXPRESS ]   AKAP8 [ SEEK ]   AKAP8 [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10270
GTEX Portal (Tissue expression)AKAP8
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43823   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43823  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43823
Splice isoforms : SwissVarO43823
PhosPhoSitePlusO43823
Domaine pattern : Prosite (Expaxy)ZF_C2H2_AKAP95 (PS51799)   
Domains : Interpro (EBI)AKAP95   
Domain families : Pfam (Sanger)AKAP95 (PF04988)   
Domain families : Pfam (NCBI)pfam04988   
Conserved Domain (NCBI)AKAP8
DMDM Disease mutations10270
Blocks (Seattle)AKAP8
SuperfamilyO43823
Human Protein AtlasENSG00000105127
Peptide AtlasO43823
HPRD05258
IPIIPI00014474   IPI01010720   
Protein Interaction databases
DIP (DOE-UCLA)O43823
IntAct (EBI)O43823
FunCoupENSG00000105127
BioGRIDAKAP8
STRING (EMBL)AKAP8
ZODIACAKAP8
Ontologies - Pathways
QuickGOO43823
Ontology : AmiGOmitotic cell cycle  condensed chromosome  female pronucleus  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  Golgi apparatus  transcription, DNA-templated  regulation of transcription, DNA-templated  mitotic chromosome condensation  signal transduction  zinc ion binding  protein transport  membrane  nuclear matrix  nuclear matrix  DEAD/H-box RNA helicase binding  positive regulation of histone deacetylation  negative regulation of tumor necrosis factor production  regulation of histone phosphorylation  protein kinase A regulatory subunit binding  histone deacetylase binding  cell cycle G2/M phase transition  innate immune response  NF-kappaB binding  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  
Ontology : EGO-EBImitotic cell cycle  condensed chromosome  female pronucleus  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  Golgi apparatus  transcription, DNA-templated  regulation of transcription, DNA-templated  mitotic chromosome condensation  signal transduction  zinc ion binding  protein transport  membrane  nuclear matrix  nuclear matrix  DEAD/H-box RNA helicase binding  positive regulation of histone deacetylation  negative regulation of tumor necrosis factor production  regulation of histone phosphorylation  protein kinase A regulatory subunit binding  histone deacetylase binding  cell cycle G2/M phase transition  innate immune response  NF-kappaB binding  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  
Pathways : BIOCARTAAKAP95 role in mitosis and chromosome dynamics [Genes]   
NDEx NetworkAKAP8
Atlas of Cancer Signalling NetworkAKAP8
Wikipedia pathwaysAKAP8
Orthology - Evolution
OrthoDB10270
GeneTree (enSembl)ENSG00000105127
Phylogenetic Trees/Animal Genes : TreeFamAKAP8
HOVERGENO43823
HOGENOMO43823
Homologs : HomoloGeneAKAP8
Homology/Alignments : Family Browser (UCSC)AKAP8
Gene fusions - Rearrangements
Fusion : MitelmanADCK4/AKAP8 [19q13.2/19p13.12]  [t(19;19)(p13;q13)]  
Fusion : MitelmanAKAP8/VMP1 [19p13.12/17q23.1]  [t(17;19)(q23;p13)]  
Fusion: TCGAADCK4 19q13.2 AKAP8 19p13.12 LUAD
Fusion: TCGAAKAP8 19p13.12 VMP1 17q23.1 BRCA
Fusion Cancer (Beijing)MTRNR2L8 [11p15.4]  -  AKAP8 [19p13.12]  [FUSC001365]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP8
dbVarAKAP8
ClinVarAKAP8
1000_GenomesAKAP8 
Exome Variant ServerAKAP8
ExAC (Exome Aggregation Consortium)AKAP8 (select the gene name)
Genetic variants : HAPMAP10270
Genomic Variants (DGV)AKAP8 [DGVbeta]
DECIPHERAKAP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKAP8 
Mutations
ICGC Data PortalAKAP8 
TCGA Data PortalAKAP8 
Broad Tumor PortalAKAP8
OASIS PortalAKAP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKAP8
DgiDB (Drug Gene Interaction Database)AKAP8
DoCM (Curated mutations)AKAP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP8 (select a term)
intoGenAKAP8
Cancer3DAKAP8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604692   
Orphanet
MedgenAKAP8
Genetic Testing Registry AKAP8
NextProtO43823 [Medical]
TSGene10270
GENETestsAKAP8
Target ValidationAKAP8
Huge Navigator AKAP8 [HugePedia]
snp3D : Map Gene to Disease10270
BioCentury BCIQAKAP8
ClinGenAKAP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10270
Chemical/Pharm GKB GenePA24672
Clinical trialAKAP8
Miscellaneous
canSAR (ICR)AKAP8 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP8
EVEXAKAP8
GoPubMedAKAP8
iHOPAKAP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:43 CEST 2017

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