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AKAP8L (A kinase (PRKA) anchor protein 8-like)

Identity

Alias_namesA kinase (PRKA) anchor protein 8-like
Alias_symbol (synonym)NAKAP95
HAP95
Other aliasHA95
NAKAP
HGNC (Hugo) AKAP8L
LocusID (NCBI) 26993
Atlas_Id 60226
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 15490859 and ends at 15529932 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKAP8L (19p13.12) / ADAMTS2 (5q35.3)AKAP8L (19p13.12) / AKAP8 (19p13.12)AKAP8L (19p13.12) / EFCAB3 (17q23.2)
AKAP8L (19p13.12) / FGFR1 (8p11.23)CTD-2192J16.17 () / AKAP8L (19p13.12)HEG1 (3q21.2) / AKAP8L (19p13.12)
KDM4B (19p13.3) / AKAP8L (19p13.12)CTD-2192J16.17 AKAP8LKDM4B AKAP8L

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKAP8L   29857
Cards
Entrez_Gene (NCBI)AKAP8L  26993  A kinase (PRKA) anchor protein 8-like
AliasesHA95; HAP95; NAKAP; NAKAP95
GeneCards (Weizmann)AKAP8L
Ensembl hg19 (Hinxton)ENSG00000011243 [Gene_View]  chr19:15490859-15529932 [Contig_View]  AKAP8L [Vega]
Ensembl hg38 (Hinxton)ENSG00000011243 [Gene_View]  chr19:15490859-15529932 [Contig_View]  AKAP8L [Vega]
ICGC DataPortalENSG00000011243
TCGA cBioPortalAKAP8L
AceView (NCBI)AKAP8L
Genatlas (Paris)AKAP8L
WikiGenes26993
SOURCE (Princeton)AKAP8L
Genetics Home Reference (NIH)AKAP8L
Genomic and cartography
GoldenPath hg19 (UCSC)AKAP8L  -     chr19:15490859-15529932 -  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AKAP8L  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblAKAP8L - 19p13.12 [CytoView hg19]  AKAP8L - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIAKAP8L [Mapview hg19]  AKAP8L [Mapview hg38]
OMIM609475   
Gene and transcription
Genbank (Entrez)AB015332 AB025905 AB451326 AB451469 AF199414
RefSeq transcript (Entrez)NM_001291478 NM_014371
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)AKAP8L
Cluster EST : UnigeneHs.399800 [ NCBI ]
CGAP (NCI)Hs.399800
Alternative Splicing GalleryENSG00000011243
Gene ExpressionAKAP8L [ NCBI-GEO ]   AKAP8L [ EBI - ARRAY_EXPRESS ]   AKAP8L [ SEEK ]   AKAP8L [ MEM ]
Gene Expression Viewer (FireBrowse)AKAP8L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26993
GTEX Portal (Tissue expression)AKAP8L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULX6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULX6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULX6
Splice isoforms : SwissVarQ9ULX6
PhosPhoSitePlusQ9ULX6
Domains : Interpro (EBI)AKAP95    Znf_C2H2-like   
Domain families : Pfam (Sanger)AKAP95 (PF04988)   
Domain families : Pfam (NCBI)pfam04988   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)AKAP8L
DMDM Disease mutations26993
Blocks (Seattle)AKAP8L
SuperfamilyQ9ULX6
Human Protein AtlasENSG00000011243
Peptide AtlasQ9ULX6
HPRD10641
IPIIPI00297455   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULX6
IntAct (EBI)Q9ULX6
FunCoupENSG00000011243
BioGRIDAKAP8L
STRING (EMBL)AKAP8L
ZODIACAKAP8L
Ontologies - Pathways
QuickGOQ9ULX6
Ontology : AmiGODNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  biological_process  nuclear matrix  DEAD/H-box RNA helicase binding  poly(A) RNA binding  metal ion binding  
Ontology : EGO-EBIDNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  biological_process  nuclear matrix  DEAD/H-box RNA helicase binding  poly(A) RNA binding  metal ion binding  
Pathways : KEGGEpstein-Barr virus infection   
NDEx NetworkAKAP8L
Atlas of Cancer Signalling NetworkAKAP8L
Wikipedia pathwaysAKAP8L
Orthology - Evolution
OrthoDB26993
GeneTree (enSembl)ENSG00000011243
Phylogenetic Trees/Animal Genes : TreeFamAKAP8L
HOVERGENQ9ULX6
HOGENOMQ9ULX6
Homologs : HomoloGeneAKAP8L
Homology/Alignments : Family Browser (UCSC)AKAP8L
Gene fusions - Rearrangements
Fusion: TCGACTD-2192J16.17 AKAP8L
Fusion: TCGAKDM4B AKAP8L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKAP8L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKAP8L
dbVarAKAP8L
ClinVarAKAP8L
1000_GenomesAKAP8L 
Exome Variant ServerAKAP8L
ExAC (Exome Aggregation Consortium)AKAP8L (select the gene name)
Genetic variants : HAPMAP26993
Genomic Variants (DGV)AKAP8L [DGVbeta]
DECIPHER (Syndromes)19:15490859-15529932  ENSG00000011243
CONAN: Copy Number AnalysisAKAP8L 
Mutations
ICGC Data PortalAKAP8L 
TCGA Data PortalAKAP8L 
Broad Tumor PortalAKAP8L
OASIS PortalAKAP8L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKAP8L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKAP8L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKAP8L
DgiDB (Drug Gene Interaction Database)AKAP8L
DoCM (Curated mutations)AKAP8L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKAP8L (select a term)
intoGenAKAP8L
Cancer3DAKAP8L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609475   
Orphanet
MedgenAKAP8L
Genetic Testing Registry AKAP8L
NextProtQ9ULX6 [Medical]
TSGene26993
GENETestsAKAP8L
Huge Navigator AKAP8L [HugePedia]
snp3D : Map Gene to Disease26993
BioCentury BCIQAKAP8L
ClinGenAKAP8L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26993
Chemical/Pharm GKB GenePA134867364
Clinical trialAKAP8L
Miscellaneous
canSAR (ICR)AKAP8L (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKAP8L
EVEXAKAP8L
GoPubMedAKAP8L
iHOPAKAP8L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:54:01 CET 2017

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