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AKR1B1 (aldo-keto reductase family 1 member B)

Identity

Alias_namesALDR1
aldo-keto reductase family 1
Alias_symbol (synonym)AR
Other aliasADR
ALR2
HGNC (Hugo) AKR1B1
LocusID (NCBI) 231
Atlas_Id 610
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 134442350 and ends at 134459192 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKR1B1 (7q33) / ITK (5q33.3)AKR1B1 (7q33) / PPP1R21 (2p16.3)JADE2 (5q31.1) / AKR1B1 (7q33)
KDM4A (1p34.1) / AKR1B1 (7q33)TBCD (17q25.3) / AKR1B1 (7q33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKR1B1   381
Cards
Entrez_Gene (NCBI)AKR1B1  231  aldo-keto reductase family 1 member B
AliasesADR; ALDR1; ALR2; AR
GeneCards (Weizmann)AKR1B1
Ensembl hg19 (Hinxton)ENSG00000085662 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085662 [Gene_View]  ENSG00000085662 [Sequence]  chr7:134442350-134459192 [Contig_View]  AKR1B1 [Vega]
ICGC DataPortalENSG00000085662
TCGA cBioPortalAKR1B1
AceView (NCBI)AKR1B1
Genatlas (Paris)AKR1B1
WikiGenes231
SOURCE (Princeton)AKR1B1
Genetics Home Reference (NIH)AKR1B1
Genomic and cartography
GoldenPath hg38 (UCSC)AKR1B1  -     chr7:134442350-134459192 -  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKR1B1  -     7q33   [Description]    (hg19-Feb_2009)
EnsemblAKR1B1 - 7q33 [CytoView hg19]  AKR1B1 - 7q33 [CytoView hg38]
Mapping of homologs : NCBIAKR1B1 [Mapview hg19]  AKR1B1 [Mapview hg38]
OMIM103880   
Gene and transcription
Genbank (Entrez)AA599612 AB209796 AF328729 AK311339 AK313439
RefSeq transcript (Entrez)NM_001346142 NM_001628
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKR1B1
Cluster EST : UnigeneHs.521212 [ NCBI ]
CGAP (NCI)Hs.521212
Alternative Splicing GalleryENSG00000085662
Gene ExpressionAKR1B1 [ NCBI-GEO ]   AKR1B1 [ EBI - ARRAY_EXPRESS ]   AKR1B1 [ SEEK ]   AKR1B1 [ MEM ]
Gene Expression Viewer (FireBrowse)AKR1B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)231
GTEX Portal (Tissue expression)AKR1B1
Human Protein AtlasENSG00000085662-AKR1B1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15121   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15121  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15121
Splice isoforms : SwissVarP15121
Catalytic activity : Enzyme1.1.1.21 [ Enzyme-Expasy ]   1.1.1.211.1.1.21 [ IntEnz-EBI ]   1.1.1.21 [ BRENDA ]   1.1.1.21 [ KEGG ]   
PhosPhoSitePlusP15121
Domaine pattern : Prosite (Expaxy)ALDOKETO_REDUCTASE_1 (PS00798)    ALDOKETO_REDUCTASE_2 (PS00062)    ALDOKETO_REDUCTASE_3 (PS00063)   
Domains : Interpro (EBI)Aldo/ket_reductase_CS    Aldo/keto_reductase    NADP_OxRdtase_dom   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)AKR1B1
DMDM Disease mutations231
Blocks (Seattle)AKR1B1
PDB (SRS)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
PDB (PDBSum)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
PDB (IMB)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
PDB (RSDB)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
Structural Biology KnowledgeBase1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
SCOP (Structural Classification of Proteins)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
CATH (Classification of proteins structures)1ABN    1ADS    1AZ1    1AZ2    1EF3    1EL3    1IEI    1MAR    1PWL    1PWM    1T40    1T41    1US0    1X96    1X97    1X98    1XGD    1Z3N    1Z89    1Z8A    2ACQ    2ACR    2ACS    2ACU    2AGT    2DUX    2DUZ    2DV0    2F2K    2FZ8    2FZ9    2FZB    2FZD    2HV5    2HVN    2HVO    2I16    2I17    2IKG    2IKH    2IKI    2IKJ    2INE    2INZ    2IPW    2IQ0    2IQD    2IS7    2ISF    2J8T    2NVC    2NVD    2PD5    2PD9    2PDB    2PDC    2PDF    2PDG    2PDH    2PDI    2PDJ    2PDK    2PDL    2PDM    2PDN    2PDP    2PDQ    2PDU    2PDW    2PDX    2PDY    2PEV    2PF8    2PFH    2PZN    2QXW    2R24    3BCJ    3DN5    3G5E    3GHR    3GHS    3GHT    3GHU    3LBO    3LD5    3LEN    3LEP    3LQG    3LQL    3LZ3    3LZ5    3M0I    3M4H    3M64    3MB9    3MC5    3ONB    3ONC    3P2V    3Q65    3Q67    3RX2    3RX3    3RX4    3S3G    3T42    3U2C    3V35    3V36    4GCA    4GQ0    4IGS    4JIR    4LAU    4LAZ    4LB3    4LB4    4LBR    4LBS    4NKC    4PR4    4PRR    4PRT    4PUU    4PUW    4Q7B    4QBX    4QR6    4QX4    4QXI    4RPQ    4XZH    4XZI    4YS1    4YU1    5HA7   
SuperfamilyP15121
Human Protein Atlas [tissue]ENSG00000085662-AKR1B1 [tissue]
Peptide AtlasP15121
HPRD00071
IPIIPI00413641   IPI00556258   IPI00926520   
Protein Interaction databases
DIP (DOE-UCLA)P15121
IntAct (EBI)P15121
FunCoupENSG00000085662
BioGRIDAKR1B1
STRING (EMBL)AKR1B1
ZODIACAKR1B1
Ontologies - Pathways
QuickGOP15121
Ontology : AmiGOtissue homeostasis  renal water homeostasis  alditol:NADP+ 1-oxidoreductase activity  alditol:NADP+ 1-oxidoreductase activity  extracellular space  nucleoplasm  cytosol  cytosol  carbohydrate metabolic process  sorbitol biosynthetic process  C21-steroid hormone biosynthetic process  electron transfer activity  response to water deprivation  naphthalene metabolic process  electron transport chain  stress-activated protein kinase signaling cascade  plasma membrane bounded cell projection cytoplasm  paranodal junction  regulation of urine volume  norepinephrine metabolic process  mast cell granule  negative regulation of apoptotic process  Schmidt-Lanterman incisure  glyceraldehyde oxidoreductase activity  daunorubicin metabolic process  doxorubicin metabolic process  fructose biosynthetic process  positive regulation of JAK-STAT cascade  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  oxidation-reduction process  maternal process involved in female pregnancy  extracellular exosome  cellular hyperosmotic salinity response  inner medullary collecting duct development  response to thyroid hormone  cellular response to methylglyoxal  Schwann cell microvillus  cellular response to peptide  
Ontology : EGO-EBItissue homeostasis  renal water homeostasis  alditol:NADP+ 1-oxidoreductase activity  alditol:NADP+ 1-oxidoreductase activity  extracellular space  nucleoplasm  cytosol  cytosol  carbohydrate metabolic process  sorbitol biosynthetic process  C21-steroid hormone biosynthetic process  electron transfer activity  response to water deprivation  naphthalene metabolic process  electron transport chain  stress-activated protein kinase signaling cascade  plasma membrane bounded cell projection cytoplasm  paranodal junction  regulation of urine volume  norepinephrine metabolic process  mast cell granule  negative regulation of apoptotic process  Schmidt-Lanterman incisure  glyceraldehyde oxidoreductase activity  daunorubicin metabolic process  doxorubicin metabolic process  fructose biosynthetic process  positive regulation of JAK-STAT cascade  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  oxidation-reduction process  maternal process involved in female pregnancy  extracellular exosome  cellular hyperosmotic salinity response  inner medullary collecting duct development  response to thyroid hormone  cellular response to methylglyoxal  Schwann cell microvillus  cellular response to peptide  
Pathways : KEGGPentose and glucuronate interconversions    Fructose and mannose metabolism    Glycerolipid metabolism    Pyruvate metabolism    Galactose metabolism   
NDEx NetworkAKR1B1
Atlas of Cancer Signalling NetworkAKR1B1
Wikipedia pathwaysAKR1B1
Orthology - Evolution
OrthoDB231
GeneTree (enSembl)ENSG00000085662
Phylogenetic Trees/Animal Genes : TreeFamAKR1B1
HOVERGENP15121
HOGENOMP15121
Homologs : HomoloGeneAKR1B1
Homology/Alignments : Family Browser (UCSC)AKR1B1
Gene fusions - Rearrangements
Fusion : QuiverAKR1B1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKR1B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKR1B1
dbVarAKR1B1
ClinVarAKR1B1
1000_GenomesAKR1B1 
Exome Variant ServerAKR1B1
ExAC (Exome Aggregation Consortium)ENSG00000085662
GNOMAD BrowserENSG00000085662
Genetic variants : HAPMAP231
Genomic Variants (DGV)AKR1B1 [DGVbeta]
DECIPHERAKR1B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKR1B1 
Mutations
ICGC Data PortalAKR1B1 
TCGA Data PortalAKR1B1 
Broad Tumor PortalAKR1B1
OASIS PortalAKR1B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKR1B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKR1B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKR1B1
DgiDB (Drug Gene Interaction Database)AKR1B1
DoCM (Curated mutations)AKR1B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKR1B1 (select a term)
intoGenAKR1B1
Cancer3DAKR1B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103880   
Orphanet
DisGeNETAKR1B1
MedgenAKR1B1
Genetic Testing Registry AKR1B1
NextProtP15121 [Medical]
TSGene231
GENETestsAKR1B1
Target ValidationAKR1B1
Huge Navigator AKR1B1 [HugePedia]
snp3D : Map Gene to Disease231
BioCentury BCIQAKR1B1
ClinGenAKR1B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD231
Chemical/Pharm GKB GenePA24675
Clinical trialAKR1B1
Miscellaneous
canSAR (ICR)AKR1B1 (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKR1B1
EVEXAKR1B1
GoPubMedAKR1B1
iHOPAKR1B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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