Identity
HGNC
LOCATION
7q33
LOCUSID
ALIAS
ADR,ALDR1,ALR2,AR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 231
MIM: 103880
HGNC: 381
Ensembl: ENSG00000085662
Variants:
dbSNP: 231
ClinVar: 231
TCGA: ENSG00000085662
COSMIC: AKR1B1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000085662 | ENST00000285930 | P15121 |
| ENSG00000085662 | ENST00000285930 | A0A024R7A8 |
| ENSG00000085662 | ENST00000426422 | E9PEF9 |
| ENSG00000085662 | ENST00000434222 | E9PCX2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38185272 | 2024 | Aldose reductase is a potential therapeutic target for neurodegeneration. | 1 |
| 38185272 | 2024 | Aldose reductase is a potential therapeutic target for neurodegeneration. | 1 |
| 36319788 | 2023 | Association of candidate genes (ALR2, RAGE, and VEGF) polymorphisms with diabetic retinopathy in type 2 diabetic patients of Khyber Pakhtunkhwa, Pakistan. | 1 |
| 37011733 | 2023 | Aldose reductase and cancer metabolism: The master regulator in the limelight. | 0 |
| 37218221 | 2023 | Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics. | 0 |
| 37285280 | 2023 | Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer. | 2 |
| 37336288 | 2023 | LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1. | 2 |
| 36319788 | 2023 | Association of candidate genes (ALR2, RAGE, and VEGF) polymorphisms with diabetic retinopathy in type 2 diabetic patients of Khyber Pakhtunkhwa, Pakistan. | 1 |
| 37011733 | 2023 | Aldose reductase and cancer metabolism: The master regulator in the limelight. | 0 |
| 37218221 | 2023 | Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics. | 0 |
| 37285280 | 2023 | Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer. | 2 |
| 37336288 | 2023 | LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1. | 2 |
| 34773353 | 2022 | Homozygosity of the Z-2 polymorphic variant in the aldose reductase gene promoter confers increased risk for neuropathy in children and adolescents with Type 1 diabetes. | 0 |
| 35029856 | 2022 | The A allele of the rs759853 single nucleotide polymorphism in the AKR1B1 gene confers risk for diabetic kidney disease in patients with type 2 diabetes from a Brazilian population. | 3 |
| 35984530 | 2022 | Identification of missense SNP-mediated mutations in the regulatory sites of aldose reductase (ALR2) responsible for treatment failure in diabetic complications. | 0 |
Citation
Dessen P
AKR1B1 (aldo-keto reductase family 1 member B)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/610/akr1b1
