AKR1B1 (aldo-keto reductase family 1 member B)

2003-08-01  

Identity

HGNC
AKR1B1
LOCATION
7q33
LOCUSID
231
ALIAS
ADR,ALDR1,ALR2,AR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 231
MIM: 103880
HGNC: 381
Ensembl: ENSG00000085662

Variants:

dbSNP: 231
ClinVar: 231
TCGA: ENSG00000085662
COSMIC: AKR1B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085662ENST00000285930P15121
ENSG00000085662ENST00000285930A0A024R7A8
ENSG00000085662ENST00000426422E9PEF9
ENSG00000085662ENST00000434222E9PCX2

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Glycerolipid metabolismKEGGko00561
Pentose and glucuronate interconversionsKEGGhsa00040
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Fructose metabolismREACTOMER-HSA-5652084
Fructose biosynthesisREACTOMER-HSA-5652227
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Pregnenolone biosynthesisREACTOMER-HSA-196108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
201505322010Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.60
152842192004Central role for aldose reductase pathway in myocardial ischemic injury.41
170186292006Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.41
210675722010Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy.33
203541212010Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.28
213296842011Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.26
241868622014Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals.26
244746492014Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.26
152842212004Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells.24

Citation

Dessen P

AKR1B1 (aldo-keto reductase family 1 member B)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/610/akr1b1