Atlas of Genetics and Cytogenetics in Oncology and Haematology

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AKR1B10 (aldo-keto reductase family 1 member B10)

Identity

Alias_namesAKR1B11
aldo-keto reductase family 1, member B10 (aldose reductase)
Alias_symbol (synonym)AKR1B12
ARL-1
HIS
ARL1
HSI
ALDRLn
Other alias
HGNC (Hugo) AKR1B10
LocusID (NCBI) 57016
Atlas_Id 611
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 134527567 and ends at 134541412 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AKR1B10   382
Cards
Entrez_Gene (NCBI)AKR1B10  57016  aldo-keto reductase family 1 member B10
AliasesAKR1B11; AKR1B12; ALDRLn; ARL-1; 
ARL1; HIS; HSI
GeneCards (Weizmann)AKR1B10
Ensembl hg19 (Hinxton)ENSG00000198074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198074 [Gene_View]  ENSG00000198074 [Sequence]  chr7:134527567-134541412 [Contig_View]  AKR1B10 [Vega]
ICGC DataPortalENSG00000198074
TCGA cBioPortalAKR1B10
AceView (NCBI)AKR1B10
Genatlas (Paris)AKR1B10
WikiGenes57016
SOURCE (Princeton)AKR1B10
Genetics Home Reference (NIH)AKR1B10
Genomic and cartography
GoldenPath hg38 (UCSC)AKR1B10  -     chr7:134527567-134541412 +  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKR1B10  -     7q33   [Description]    (hg19-Feb_2009)
GoldenPathAKR1B10 - 7q33 [CytoView hg19]  AKR1B10 - 7q33 [CytoView hg38]
Genome Data Viewer NCBIAKR1B10 [Mapview hg19]  
OMIM604707   
Gene and transcription
Genbank (Entrez)AF044961 AF052577 AF524864 BC008837 BM975664
RefSeq transcript (Entrez)NM_020299
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKR1B10
Alternative Splicing GalleryENSG00000198074
Gene ExpressionAKR1B10 [ NCBI-GEO ]   AKR1B10 [ EBI - ARRAY_EXPRESS ]   AKR1B10 [ SEEK ]   AKR1B10 [ MEM ]
Gene Expression Viewer (FireBrowse)AKR1B10 [ Firebrowse - Broad ]
GenevisibleExpression of AKR1B10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57016
GTEX Portal (Tissue expression)AKR1B10
Human Protein AtlasENSG00000198074-AKR1B10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60218   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60218  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60218
Splice isoforms : SwissVarO60218
PhosPhoSitePlusO60218
Domaine pattern : Prosite (Expaxy)ALDOKETO_REDUCTASE_1 (PS00798)    ALDOKETO_REDUCTASE_2 (PS00062)    ALDOKETO_REDUCTASE_3 (PS00063)   
Domains : Interpro (EBI)Aldo/ket_reductase_CS    Aldo/keto_reductase    NADP_OxRdtase_dom    NADP_OxRdtase_dom_sf   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)AKR1B10
DMDM Disease mutations57016
PDB (RSDB)1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
PDB Europe1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
PDB (PDBSum)1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
PDB (IMB)1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
Structural Biology KnowledgeBase1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
SCOP (Structural Classification of Proteins)1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
CATH (Classification of proteins structures)1ZUA    4GA8    4GAB    4GQ0    4GQG    4I5X    4ICC    4JIH    4JII    4WEV    4XZL    4XZM    4XZN    5LIK    5LIU    5LIW    5LIX    5LIY    5M2F    5Y7N   
SuperfamilyO60218
Human Protein Atlas [tissue]ENSG00000198074-AKR1B10 [tissue]
Peptide AtlasO60218
HPRD05271
IPIIPI00105407   
Protein Interaction databases
DIP (DOE-UCLA)O60218
IntAct (EBI)O60218
FunCoupENSG00000198074
BioGRIDAKR1B10
STRING (EMBL)AKR1B10
ZODIACAKR1B10
Ontologies - Pathways
QuickGOO60218
Ontology : AmiGOretinoid metabolic process  retinoid metabolic process  retinal dehydrogenase activity  alditol:NADP+ 1-oxidoreductase activity  aldo-keto reductase (NADP) activity  protein binding  extracellular region  mitochondrion  lysosome  cytosol  cytosol  alcohol dehydrogenase (NADP+) activity  alcohol dehydrogenase (NADP+) activity  farnesol catabolic process  oxidoreductase activity  retinol metabolic process  daunorubicin metabolic process  doxorubicin metabolic process  geranylgeranyl reductase activity  allyl-alcohol dehydrogenase activity  indanol dehydrogenase activity  NADP-retinol dehydrogenase activity  oxidation-reduction process  cellular detoxification of aldehyde  
Ontology : EGO-EBIretinoid metabolic process  retinoid metabolic process  retinal dehydrogenase activity  alditol:NADP+ 1-oxidoreductase activity  aldo-keto reductase (NADP) activity  protein binding  extracellular region  mitochondrion  lysosome  cytosol  cytosol  alcohol dehydrogenase (NADP+) activity  alcohol dehydrogenase (NADP+) activity  farnesol catabolic process  oxidoreductase activity  retinol metabolic process  daunorubicin metabolic process  doxorubicin metabolic process  geranylgeranyl reductase activity  allyl-alcohol dehydrogenase activity  indanol dehydrogenase activity  NADP-retinol dehydrogenase activity  oxidation-reduction process  cellular detoxification of aldehyde  
Pathways : KEGGPentose and glucuronate interconversions    Fructose and mannose metabolism    Galactose metabolism    Glycerolipid metabolism    Pyruvate metabolism   
NDEx NetworkAKR1B10
Atlas of Cancer Signalling NetworkAKR1B10
Wikipedia pathwaysAKR1B10
Orthology - Evolution
OrthoDB57016
GeneTree (enSembl)ENSG00000198074
Phylogenetic Trees/Animal Genes : TreeFamAKR1B10
HOGENOMO60218
Homologs : HomoloGeneAKR1B10
Homology/Alignments : Family Browser (UCSC)AKR1B10
Gene fusions - Rearrangements
Fusion : QuiverAKR1B10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKR1B10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKR1B10
dbVarAKR1B10
ClinVarAKR1B10
1000_GenomesAKR1B10 
Exome Variant ServerAKR1B10
GNOMAD BrowserENSG00000198074
Varsome BrowserAKR1B10
Genetic variants : HAPMAP57016
Genomic Variants (DGV)AKR1B10 [DGVbeta]
DECIPHERAKR1B10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKR1B10 
Mutations
ICGC Data PortalAKR1B10 
TCGA Data PortalAKR1B10 
Broad Tumor PortalAKR1B10
OASIS PortalAKR1B10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKR1B10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAKR1B10
Mutations and Diseases : HGMDAKR1B10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect AKR1B10
DgiDB (Drug Gene Interaction Database)AKR1B10
DoCM (Curated mutations)AKR1B10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKR1B10 (select a term)
intoGenAKR1B10
Cancer3DAKR1B10 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604707   
Orphanet
DisGeNETAKR1B10
MedgenAKR1B10
Genetic Testing Registry AKR1B10
NextProtO60218 [Medical]
TSGene57016
GENETestsAKR1B10
Open Targets GeneticsENSG00000198074  [validation]
snp3D : Map Gene to Disease57016
BioCentury BCIQAKR1B10
ClinGenAKR1B10
Clinical trials, drugs, therapy
Protein Interactions : CTD57016
Pharm GKB GenePA24676
Pharm GKB PathwaysPA2035   PA2038   
Clinical trialAKR1B10
Miscellaneous
canSAR (ICR)AKR1B10 (select the gene name)
HarmonizomeAKR1B10
DataMed IndexAKR1B10
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKR1B10
EVEXAKR1B10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 19:38:28 CEST 2020
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