AKR1C1 (aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase))

Identity

Other names	2-ALPHA-HSD
	20-ALPHA-HSD
	C9
	DD1
	DDH
	DDH1
	H-37
	HAKRC
	MBAB
	MGC8954
HGNC	AKR1C1
Location	10p15-p14
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	AKR1C1   384
Entrez_Gene	AKR1C1  1645  aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
	Cards
GeneCards	AKR1C1
Ensembl	AKR1C1 [Search_View]   ENSG00000187134 [Gene_View]
Genatlas	AKR1C1
GeneLynx	AKR1C1
eGenome	AKR1C1
euGene	1645
	Genomic and cartography
GoldenPath	AKR1C1  -     chr10:4995454-5010158 +  10p15.1   [Description]    (hg18-March_2006)
Ensembl	AKR1C1 - 10p15.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	AKR1C1
	Gene and transcription
Genbank	AB031083 [ ENTREZ ]
Genbank	AK310658 [ ENTREZ ]
Genbank	BC015490 [ ENTREZ ]
Genbank	BC020216 [ ENTREZ ]
Genbank	BC040210 [ ENTREZ ]
RefSeq	NM_001353 [ SRS ]    NM_001353 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_077567 [ SRS ]    NT_077567 [ ENTREZ ]
RefSeq	NW_001837930 [ SRS ]    NW_001837930 [ ENTREZ ]
RefSeq	NW_924584 [ SRS ]    NW_924584 [ ENTREZ ]
AceView	AKR1C1 AceView - NCBI
Unigene	Hs.460260 [ SRS ]    Hs.460260 [ NCBI ]     HS460260 [ spliceNest ]
Fast-db	474 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q04828 [ SRS]    Q04828 [ EXPASY ]     Q04828 [ INTERPRO ]     Q04828 [ UNIPROT ]
Prosite	PS00798 ALDOKETO_REDUCTASE_1 [ SRS ]    PS00798 ALDOKETO_REDUCTASE_1 [ Expasy ]
Prosite	PS00062 ALDOKETO_REDUCTASE_2 [ SRS ]    PS00062 ALDOKETO_REDUCTASE_2 [ Expasy ]
Prosite	PS00063 ALDOKETO_REDUCTASE_3 [ SRS ]    PS00063 ALDOKETO_REDUCTASE_3 [ Expasy ]
Interpro	IPR001395 Aldo/ket_red [ SRS ]    IPR001395 Aldo/ket_red [ EBI ]
CluSTr	Q04828
Pfam	PF00248 Aldo_ket_red [ SRS ]    PF00248 Aldo_ket_red [ Sanger ]    pfam00248 [ NCBI-CDD ]
Prodom	PD000288 Aldo/ket_red[INRA-Toulouse]
Prodom	Q04828 AK1C1_HUMAN [ Domain structure ]   Q04828 AK1C1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q04828
PDB	1MRQ [ SRS ]    1MRQ [ PdbSum ],   1MRQ [ IMB ]   1MRQ [ RSDB ]
HPRD	07194
	Protein Interaction databases
DIP	Q04828
IntAct	Q04828
	Polymorphism : SNP, mutations, diseases
OMIM	600449    [ map ]
GENECLINICS	600449
SNP	AKR1C1 [dbSNP-NCBI]
SNP	NM_001353 [SNP-NCI]
SNP	AKR1C1 [GeneSNPs - Utah]  AKR1C1] [HGBASE - SRS]
HAPMAP	AKR1C1 [HAPMAP]
HGMD	AKR1C1
	General knowledge
Family Browser	AKR1C1 [UCSC Family Browser]
SOURCE	NM_001353
SMD	Hs.460260
SAGE	Hs.460260
Enzyme	1.1.1.- [ Enzyme-Expasy ]   1.1.1.- [ Enzyme-SRS ]   1.1.1.- [ IntEnz-EBI ]   1.1.1.- [ BRENDA ]   1.1.1.- [ KEGG ]   1.1.1.- [ WIT ]
GO	aldo-keto reductase activity [Amigo]  aldo-keto reductase activity
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	xenobiotic metabolic process [Amigo]  xenobiotic metabolic process
GO	digestion [Amigo]  digestion
GO	bile acid metabolic process [Amigo]  bile acid metabolic process
GO	bile acid and bile salt transport [Amigo]  bile acid and bile salt transport
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	cholesterol absorption [Amigo]  cholesterol absorption
GO	bile acid binding [Amigo]  bile acid binding
GO	cholesterol homeostasis [Amigo]  cholesterol homeostasis
GO	20-alpha-hydroxysteroid dehydrogenase activity [Amigo]  20-alpha-hydroxysteroid dehydrogenase activity
GO	3-alpha-hydroxysteroid dehydrogenase (B-specific) activity [Amigo]  3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
GO	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [Amigo]  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO	protein homooligomerization [Amigo]  protein homooligomerization
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Metabolism of xenobiotics by cytochrome P450
PubGene	AKR1C1
TreeFam	AKR1C1
CTD	1645 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	AKR1C1 Related clones (RZPD - Berlin)
	PubMed
PubMed	32 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:59:41 2008