Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

AKR1E2 (aldo-keto reductase family 1, member E2)

Identity

Alias_namesAKRDC1
AKR1CL2
aldo-keto reductase family 1
Alias_symbol (synonym)MGC10612
Other aliasLoopADR
hTSP
htAKR
HGNC (Hugo) AKR1E2
LocusID (NCBI) 83592
Atlas_Id 53068
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 4868369 and ends at 4890251 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FARS2 (6p25.1) / AKR1E2 (10p15.1)FARS2 6p25.1 / AKR1E2 10p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKR1E2   23437
Cards
Entrez_Gene (NCBI)AKR1E2  83592  aldo-keto reductase family 1, member E2
AliasesAKR1CL2; AKRDC1; LoopADR; hTSP; 
htAKR
GeneCards (Weizmann)AKR1E2
Ensembl hg19 (Hinxton)ENSG00000165568 [Gene_View]  chr10:4868369-4890251 [Contig_View]  AKR1E2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000165568 [Gene_View]  chr10:4868369-4890251 [Contig_View]  AKR1E2 [Vega]
ICGC DataPortalENSG00000165568
TCGA cBioPortalAKR1E2
AceView (NCBI)AKR1E2
Genatlas (Paris)AKR1E2
WikiGenes83592
SOURCE (Princeton)AKR1E2
Genetics Home Reference (NIH)AKR1E2
Genomic and cartography
GoldenPath hg19 (UCSC)AKR1E2  -     chr10:4868369-4890251 +  10p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AKR1E2  -     10p15.1   [Description]    (hg38-Dec_2013)
EnsemblAKR1E2 - 10p15.1 [CytoView hg19]  AKR1E2 - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIAKR1E2 [Mapview hg19]  AKR1E2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB040820 AB040821 AB040822 AB055603 AF263242
RefSeq transcript (Entrez)NM_001040177 NM_001271021 NM_001271025 NM_031436
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_008705 NW_004929370
Consensus coding sequences : CCDS (NCBI)AKR1E2
Cluster EST : UnigeneHs.657944 [ NCBI ]
CGAP (NCI)Hs.657944
Alternative Splicing GalleryENSG00000165568
Gene ExpressionAKR1E2 [ NCBI-GEO ]   AKR1E2 [ EBI - ARRAY_EXPRESS ]   AKR1E2 [ SEEK ]   AKR1E2 [ MEM ]
Gene Expression Viewer (FireBrowse)AKR1E2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83592
GTEX Portal (Tissue expression)AKR1E2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JD6
Splice isoforms : SwissVarQ96JD6
Catalytic activity : Enzyme1.1.1.263 [ Enzyme-Expasy ]   1.1.1.2631.1.1.263 [ IntEnz-EBI ]   1.1.1.263 [ BRENDA ]   1.1.1.263 [ KEGG ]   
PhosPhoSitePlusQ96JD6
Domaine pattern : Prosite (Expaxy)ALDOKETO_REDUCTASE_1 (PS00798)    ALDOKETO_REDUCTASE_2 (PS00062)   
Domains : Interpro (EBI)Aldo/ket_red/Kv-b    Aldo/ket_reductase_CS    Aldo/keto_reductase    NADP_OxRdtase_dom   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)AKR1E2
DMDM Disease mutations83592
Blocks (Seattle)AKR1E2
SuperfamilyQ96JD6
Human Protein AtlasENSG00000165568
Peptide AtlasQ96JD6
HPRD07472
IPIIPI00153045   IPI00384752   IPI00845396   IPI00644253   IPI00384751   IPI00978079   IPI00981106   IPI00977378   IPI00979790   IPI00981771   
Protein Interaction databases
DIP (DOE-UCLA)Q96JD6
IntAct (EBI)Q96JD6
FunCoupENSG00000165568
BioGRIDAKR1E2
STRING (EMBL)AKR1E2
ZODIACAKR1E2
Ontologies - Pathways
QuickGOQ96JD6
Ontology : AmiGOcytoplasm  1,5-anhydro-D-fructose reductase activity  oxidation-reduction process  extracellular exosome  mitophagy in response to mitochondrial depolarization  
Ontology : EGO-EBIcytoplasm  1,5-anhydro-D-fructose reductase activity  oxidation-reduction process  extracellular exosome  mitophagy in response to mitochondrial depolarization  
NDEx NetworkAKR1E2
Atlas of Cancer Signalling NetworkAKR1E2
Wikipedia pathwaysAKR1E2
Orthology - Evolution
OrthoDB83592
GeneTree (enSembl)ENSG00000165568
Phylogenetic Trees/Animal Genes : TreeFamAKR1E2
HOVERGENQ96JD6
HOGENOMQ96JD6
Homologs : HomoloGeneAKR1E2
Homology/Alignments : Family Browser (UCSC)AKR1E2
Gene fusions - Rearrangements
Fusion : MitelmanFARS2/AKR1E2 [6p25.1/10p15.1]  [t(6;10)(p25;p15)]  
Fusion: TCGAFARS2 6p25.1 AKR1E2 10p15.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKR1E2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKR1E2
dbVarAKR1E2
ClinVarAKR1E2
1000_GenomesAKR1E2 
Exome Variant ServerAKR1E2
ExAC (Exome Aggregation Consortium)AKR1E2 (select the gene name)
Genetic variants : HAPMAP83592
Genomic Variants (DGV)AKR1E2 [DGVbeta]
DECIPHER (Syndromes)10:4868369-4890251  ENSG00000165568
CONAN: Copy Number AnalysisAKR1E2 
Mutations
ICGC Data PortalAKR1E2 
TCGA Data PortalAKR1E2 
Broad Tumor PortalAKR1E2
OASIS PortalAKR1E2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKR1E2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKR1E2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKR1E2
DgiDB (Drug Gene Interaction Database)AKR1E2
DoCM (Curated mutations)AKR1E2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKR1E2 (select a term)
intoGenAKR1E2
Cancer3DAKR1E2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenAKR1E2
Genetic Testing Registry AKR1E2
NextProtQ96JD6 [Medical]
TSGene83592
GENETestsAKR1E2
Huge Navigator AKR1E2 [HugePedia]
snp3D : Map Gene to Disease83592
BioCentury BCIQAKR1E2
ClinGenAKR1E2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83592
Chemical/Pharm GKB GenePA165548224
Clinical trialAKR1E2
Miscellaneous
canSAR (ICR)AKR1E2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKR1E2
EVEXAKR1E2
GoPubMedAKR1E2
iHOPAKR1E2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:52:05 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.