Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AKR7A2 (aldo-keto reductase family 7 member A2)

Identity

Alias_symbol (synonym)AFAR
Other aliasAFAR1
AFB1-AR1
AKR7
HGNC (Hugo) AKR7A2
LocusID (NCBI) 8574
Atlas_Id 613
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 19302708 and ends at 19312146 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKR7A2   389
Cards
Entrez_Gene (NCBI)AKR7A2  8574  aldo-keto reductase family 7 member A2
AliasesAFAR; AFAR1; AFB1-AR1; AKR7
GeneCards (Weizmann)AKR7A2
Ensembl hg19 (Hinxton)ENSG00000053371 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000053371 [Gene_View]  chr1:19302708-19312146 [Contig_View]  AKR7A2 [Vega]
ICGC DataPortalENSG00000053371
TCGA cBioPortalAKR7A2
AceView (NCBI)AKR7A2
Genatlas (Paris)AKR7A2
WikiGenes8574
SOURCE (Princeton)AKR7A2
Genetics Home Reference (NIH)AKR7A2
Genomic and cartography
GoldenPath hg38 (UCSC)AKR7A2  -     chr1:19302708-19312146 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKR7A2  -     1p36.13   [Description]    (hg19-Feb_2009)
EnsemblAKR7A2 - 1p36.13 [CytoView hg19]  AKR7A2 - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIAKR7A2 [Mapview hg19]  AKR7A2 [Mapview hg38]
OMIM603418   
Gene and transcription
Genbank (Entrez)AA037839 AF026947 AK225267 AK303131 AK310609
RefSeq transcript (Entrez)NM_001320979 NM_003689
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKR7A2
Cluster EST : UnigeneHs.571886 [ NCBI ]
CGAP (NCI)Hs.571886
Alternative Splicing GalleryENSG00000053371
Gene ExpressionAKR7A2 [ NCBI-GEO ]   AKR7A2 [ EBI - ARRAY_EXPRESS ]   AKR7A2 [ SEEK ]   AKR7A2 [ MEM ]
Gene Expression Viewer (FireBrowse)AKR7A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8574
GTEX Portal (Tissue expression)AKR7A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43488   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43488  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43488
Splice isoforms : SwissVarO43488
Catalytic activity : Enzyme1.1.1.n11 [ Enzyme-Expasy ]   1.1.1.n111.1.1.n11 [ IntEnz-EBI ]   1.1.1.n11 [ BRENDA ]   1.1.1.n11 [ KEGG ]   
PhosPhoSitePlusO43488
Domains : Interpro (EBI)NADP_OxRdtase_dom   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)AKR7A2
DMDM Disease mutations8574
Blocks (Seattle)AKR7A2
PDB (SRS)2BP1   
PDB (PDBSum)2BP1   
PDB (IMB)2BP1   
PDB (RSDB)2BP1   
Structural Biology KnowledgeBase2BP1   
SCOP (Structural Classification of Proteins)2BP1   
CATH (Classification of proteins structures)2BP1   
SuperfamilyO43488
Human Protein AtlasENSG00000053371
Peptide AtlasO43488
HPRD04567
IPIIPI00305978   IPI00908691   IPI00946527   IPI00946674   IPI00946488   
Protein Interaction databases
DIP (DOE-UCLA)O43488
IntAct (EBI)O43488
FunCoupENSG00000053371
BioGRIDAKR7A2
STRING (EMBL)AKR7A2
ZODIACAKR7A2
Ontologies - Pathways
QuickGOO43488
Ontology : AmiGOalditol:NADP+ 1-oxidoreductase activity  aldo-keto reductase (NADP) activity  protein binding  Golgi apparatus  cytosol  cytosol  carbohydrate metabolic process  cellular aldehyde metabolic process  xenobiotic metabolic process  electron carrier activity  phenanthrene-9,10-epoxide hydrolase activity  daunorubicin metabolic process  doxorubicin metabolic process  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIalditol:NADP+ 1-oxidoreductase activity  aldo-keto reductase (NADP) activity  protein binding  Golgi apparatus  cytosol  cytosol  carbohydrate metabolic process  cellular aldehyde metabolic process  xenobiotic metabolic process  electron carrier activity  phenanthrene-9,10-epoxide hydrolase activity  daunorubicin metabolic process  doxorubicin metabolic process  oxidation-reduction process  extracellular exosome  
Pathways : BIOCARTAOxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
Pathways : KEGGMetabolism of xenobiotics by cytochrome P450   
NDEx NetworkAKR7A2
Atlas of Cancer Signalling NetworkAKR7A2
Wikipedia pathwaysAKR7A2
Orthology - Evolution
OrthoDB8574
GeneTree (enSembl)ENSG00000053371
Phylogenetic Trees/Animal Genes : TreeFamAKR7A2
HOVERGENO43488
HOGENOMO43488
Homologs : HomoloGeneAKR7A2
Homology/Alignments : Family Browser (UCSC)AKR7A2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKR7A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKR7A2
dbVarAKR7A2
ClinVarAKR7A2
1000_GenomesAKR7A2 
Exome Variant ServerAKR7A2
ExAC (Exome Aggregation Consortium)AKR7A2 (select the gene name)
Genetic variants : HAPMAP8574
Genomic Variants (DGV)AKR7A2 [DGVbeta]
DECIPHERAKR7A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKR7A2 
Mutations
ICGC Data PortalAKR7A2 
TCGA Data PortalAKR7A2 
Broad Tumor PortalAKR7A2
OASIS PortalAKR7A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKR7A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKR7A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AKR7A2
DgiDB (Drug Gene Interaction Database)AKR7A2
DoCM (Curated mutations)AKR7A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKR7A2 (select a term)
intoGenAKR7A2
Cancer3DAKR7A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603418   
Orphanet
MedgenAKR7A2
Genetic Testing Registry AKR7A2
NextProtO43488 [Medical]
TSGene8574
GENETestsAKR7A2
Target ValidationAKR7A2
Huge Navigator AKR7A2 [HugePedia]
snp3D : Map Gene to Disease8574
BioCentury BCIQAKR7A2
ClinGenAKR7A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8574
Chemical/Pharm GKB GenePA24682
Clinical trialAKR7A2
Miscellaneous
canSAR (ICR)AKR7A2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKR7A2
EVEXAKR7A2
GoPubMedAKR7A2
iHOPAKR7A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:23:22 CEST 2017

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