AKR7A2 (aldo-keto reductase family 7 member A2)

2003-02-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
AFAR,AFAR1,AFB1-AR1,AKR7

Other Information

Locus ID:

NCBI: 8574
MIM: 603418
HGNC: 389
Ensembl: ENSG00000053371

Variants:

dbSNP: 8574
ClinVar: 8574
TCGA: ENSG00000053371
COSMIC: AKR7A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000053371ENST00000235835O43488
ENSG00000053371ENST00000235835V9HWA2
ENSG00000053371ENST00000330072H3BLU7
ENSG00000053371ENST00000481966H7C4Q7
ENSG00000053371ENST00000489286H7C5H7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449212daunorubicinChemicalVariantAnnotationassociatedPK20837989
PA449412doxorubicinChemicalVariantAnnotationassociatedPK20837989

References

Pubmed IDYearTitleCitations
190774592009Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
175917732007Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.8
254515872015Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.6
128790232003Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.4
187528862008Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.3
250276722015GST-M1 is transcribed moreso than AKR7A2 in AFB₁-exposed human monocytes and lymphocytes.3
285366272016The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.1
308179762019Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes.0

Citation

Dessen P

AKR7A2 (aldo-keto reductase family 7 member A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/613/akr7a2