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AKR7A3 (aldo-keto reductase family 7 member A3)

Identity

Alias_namesaldo-keto reductase family 7
Other aliasAFAR2
HGNC (Hugo) AKR7A3
LocusID (NCBI) 22977
Atlas_Id 614
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 19282563 and ends at 19288786 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AKR7A3   390
Cards
Entrez_Gene (NCBI)AKR7A3  22977  aldo-keto reductase family 7 member A3
AliasesAFAR2
GeneCards (Weizmann)AKR7A3
Ensembl hg19 (Hinxton)ENSG00000162482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162482 [Gene_View]  chr1:19282563-19288786 [Contig_View]  AKR7A3 [Vega]
ICGC DataPortalENSG00000162482
TCGA cBioPortalAKR7A3
AceView (NCBI)AKR7A3
Genatlas (Paris)AKR7A3
WikiGenes22977
SOURCE (Princeton)AKR7A3
Genetics Home Reference (NIH)AKR7A3
Genomic and cartography
GoldenPath hg38 (UCSC)AKR7A3  -     chr1:19282563-19288786 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AKR7A3  -     1p36.13   [Description]    (hg19-Feb_2009)
EnsemblAKR7A3 - 1p36.13 [CytoView hg19]  AKR7A3 - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIAKR7A3 [Mapview hg19]  AKR7A3 [Mapview hg38]
OMIM608477   
Gene and transcription
Genbank (Entrez)AA844782 AF040639 AJ271799 BC025709 BC031562
RefSeq transcript (Entrez)NM_012067
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AKR7A3
Cluster EST : UnigeneHs.6980 [ NCBI ]
CGAP (NCI)Hs.6980
Alternative Splicing GalleryENSG00000162482
Gene ExpressionAKR7A3 [ NCBI-GEO ]   AKR7A3 [ EBI - ARRAY_EXPRESS ]   AKR7A3 [ SEEK ]   AKR7A3 [ MEM ]
Gene Expression Viewer (FireBrowse)AKR7A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22977
GTEX Portal (Tissue expression)AKR7A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95154   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95154  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95154
Splice isoforms : SwissVarO95154
Catalytic activity : Enzyme1.-.-.- [ Enzyme-Expasy ]   1.-.-.-1.-.-.- [ IntEnz-EBI ]   1.-.-.- [ BRENDA ]   1.-.-.- [ KEGG ]   
PhosPhoSitePlusO95154
Domains : Interpro (EBI)NADP_OxRdtase_dom   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)AKR7A3
DMDM Disease mutations22977
Blocks (Seattle)AKR7A3
PDB (SRS)2CLP   
PDB (PDBSum)2CLP   
PDB (IMB)2CLP   
PDB (RSDB)2CLP   
Structural Biology KnowledgeBase2CLP   
SCOP (Structural Classification of Proteins)2CLP   
CATH (Classification of proteins structures)2CLP   
SuperfamilyO95154
Human Protein AtlasENSG00000162482
Peptide AtlasO95154
HPRD07089
IPIIPI00293721   
Protein Interaction databases
DIP (DOE-UCLA)O95154
IntAct (EBI)O95154
FunCoupENSG00000162482
BioGRIDAKR7A3
STRING (EMBL)AKR7A3
ZODIACAKR7A3
Ontologies - Pathways
QuickGOO95154
Ontology : AmiGOaldo-keto reductase (NADP) activity  protein binding  cytosol  cytosol  cellular aldehyde metabolic process  xenobiotic metabolic process  electron carrier activity  identical protein binding  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIaldo-keto reductase (NADP) activity  protein binding  cytosol  cytosol  cellular aldehyde metabolic process  xenobiotic metabolic process  electron carrier activity  identical protein binding  oxidation-reduction process  extracellular exosome  
Pathways : KEGGMetabolism of xenobiotics by cytochrome P450   
NDEx NetworkAKR7A3
Atlas of Cancer Signalling NetworkAKR7A3
Wikipedia pathwaysAKR7A3
Orthology - Evolution
OrthoDB22977
GeneTree (enSembl)ENSG00000162482
Phylogenetic Trees/Animal Genes : TreeFamAKR7A3
HOVERGENO95154
HOGENOMO95154
Homologs : HomoloGeneAKR7A3
Homology/Alignments : Family Browser (UCSC)AKR7A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAKR7A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AKR7A3
dbVarAKR7A3
ClinVarAKR7A3
1000_GenomesAKR7A3 
Exome Variant ServerAKR7A3
ExAC (Exome Aggregation Consortium)AKR7A3 (select the gene name)
Genetic variants : HAPMAP22977
Genomic Variants (DGV)AKR7A3 [DGVbeta]
DECIPHERAKR7A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAKR7A3 
Mutations
ICGC Data PortalAKR7A3 
TCGA Data PortalAKR7A3 
Broad Tumor PortalAKR7A3
OASIS PortalAKR7A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAKR7A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAKR7A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AKR7A3
DgiDB (Drug Gene Interaction Database)AKR7A3
DoCM (Curated mutations)AKR7A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AKR7A3 (select a term)
intoGenAKR7A3
Cancer3DAKR7A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608477   
Orphanet
MedgenAKR7A3
Genetic Testing Registry AKR7A3
NextProtO95154 [Medical]
TSGene22977
GENETestsAKR7A3
Target ValidationAKR7A3
Huge Navigator AKR7A3 [HugePedia]
snp3D : Map Gene to Disease22977
BioCentury BCIQAKR7A3
ClinGenAKR7A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22977
Chemical/Pharm GKB GenePA24683
Clinical trialAKR7A3
Miscellaneous
canSAR (ICR)AKR7A3 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAKR7A3
EVEXAKR7A3
GoPubMedAKR7A3
iHOPAKR7A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:51 CEST 2017

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