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ALCAM (activated leukocyte cell adhesion molecule)

Identity

Alias_namesactivated leucocyte cell adhesion molecule
Alias_symbol (synonym)CD166
MEMD
Other alias
HGNC (Hugo) ALCAM
LocusID (NCBI) 214
Atlas_Id 616
Location 3q13.11  [Link to chromosome band 3q13]
Location_base_pair Starts at 105085557 and ends at 105295757 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AHDC1 (1p36.11) / ALCAM (3q13.11)ALCAM (3q13.11) / ALCAM (3q13.11)ALCAM (3q13.11) / EIF2A (3q25.1)
ALCAM (3q13.11) / EPHA6 (3q11.2)ALCAM (3q13.11) / LYZ (12q15)ALCAM (3q13.11) / SH3KBP1 (Xp22.12)
ALCAM (3q13.11) / TBC1D12 (10q23.33)ALCAM (3q13.11) / YIF1B (19q13.2)FCGRT (19q13.33) / ALCAM (3q13.11)
AHDC1 1p36.11 / ALCAM 3q13.11ALCAM 3q13.11 / EIF2A 3q25.1ALCAM 3q13.11 / SH3KBP1 Xp22.12
ALCAM 3q13.11 / YIF1B 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ALCAM   400
Cards
Entrez_Gene (NCBI)ALCAM  214  activated leukocyte cell adhesion molecule
AliasesCD166; MEMD
GeneCards (Weizmann)ALCAM
Ensembl hg19 (Hinxton)ENSG00000170017 [Gene_View]  chr3:105085557-105295757 [Contig_View]  ALCAM [Vega]
Ensembl hg38 (Hinxton)ENSG00000170017 [Gene_View]  chr3:105085557-105295757 [Contig_View]  ALCAM [Vega]
ICGC DataPortalENSG00000170017
TCGA cBioPortalALCAM
AceView (NCBI)ALCAM
Genatlas (Paris)ALCAM
WikiGenes214
SOURCE (Princeton)ALCAM
Genetics Home Reference (NIH)ALCAM
Genomic and cartography
GoldenPath hg19 (UCSC)ALCAM  -     chr3:105085557-105295757 +  3q13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALCAM  -     3q13.11   [Description]    (hg38-Dec_2013)
EnsemblALCAM - 3q13.11 [CytoView hg19]  ALCAM - 3q13.11 [CytoView hg38]
Mapping of homologs : NCBIALCAM [Mapview hg19]  ALCAM [Mapview hg38]
OMIM601662   
Gene and transcription
Genbank (Entrez)AB074167 AK054632 AK095833 AK127617 AK300362
RefSeq transcript (Entrez)NM_001243280 NM_001243281 NM_001243283 NM_001627
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_029729 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)ALCAM
Cluster EST : UnigeneHs.740441 [ NCBI ]
CGAP (NCI)Hs.740441
Alternative Splicing GalleryENSG00000170017
Gene ExpressionALCAM [ NCBI-GEO ]   ALCAM [ EBI - ARRAY_EXPRESS ]   ALCAM [ SEEK ]   ALCAM [ MEM ]
Gene Expression Viewer (FireBrowse)ALCAM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)214
GTEX Portal (Tissue expression)ALCAM
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13740   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13740  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13740
Splice isoforms : SwissVarQ13740
PhosPhoSitePlusQ13740
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)   
Domain families : Pfam (NCBI)pfam08205   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)ALCAM
DMDM Disease mutations214
Blocks (Seattle)ALCAM
PDB (SRS)1KJC    5A2F   
PDB (PDBSum)1KJC    5A2F   
PDB (IMB)1KJC    5A2F   
PDB (RSDB)1KJC    5A2F   
Structural Biology KnowledgeBase1KJC    5A2F   
SCOP (Structural Classification of Proteins)1KJC    5A2F   
CATH (Classification of proteins structures)1KJC    5A2F   
SuperfamilyQ13740
Human Protein AtlasENSG00000170017
Peptide AtlasQ13740
HPRD03389
IPIIPI00015102   IPI00807403   IPI00748835   IPI00944977   IPI00795504   
Protein Interaction databases
DIP (DOE-UCLA)Q13740
IntAct (EBI)Q13740
FunCoupENSG00000170017
BioGRIDALCAM
STRING (EMBL)ALCAM
ZODIACALCAM
Ontologies - Pathways
QuickGOQ13740
Ontology : AmiGOimmunological synapse  adaptive immune response  receptor binding  protein binding  integral component of plasma membrane  focal adhesion  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  motor neuron axon guidance  external side of plasma membrane  axon  dendrite  intrinsic component of plasma membrane  retinal ganglion cell axon guidance  T cell receptor complex  neuronal cell body  axon extension involved in axon guidance  extracellular exosome  neuron projection extension  
Ontology : EGO-EBIimmunological synapse  adaptive immune response  receptor binding  protein binding  integral component of plasma membrane  focal adhesion  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  motor neuron axon guidance  external side of plasma membrane  axon  dendrite  intrinsic component of plasma membrane  retinal ganglion cell axon guidance  T cell receptor complex  neuronal cell body  axon extension involved in axon guidance  extracellular exosome  neuron projection extension  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkALCAM
Atlas of Cancer Signalling NetworkALCAM
Wikipedia pathwaysALCAM
Orthology - Evolution
OrthoDB214
GeneTree (enSembl)ENSG00000170017
Phylogenetic Trees/Animal Genes : TreeFamALCAM
HOVERGENQ13740
HOGENOMQ13740
Homologs : HomoloGeneALCAM
Homology/Alignments : Family Browser (UCSC)ALCAM
Gene fusions - Rearrangements
Fusion : MitelmanAHDC1/ALCAM [1p36.11/3q13.11]  [t(1;3)(p36;q13)]  
Fusion : MitelmanALCAM/EIF2A [3q13.11/3q25.1]  [t(3;3)(q13;q25)]  
Fusion : MitelmanALCAM/EPHA6 [3q13.11/3q11.2]  [t(3;3)(q11;q13)]  
Fusion : MitelmanALCAM/SH3KBP1 [3q13.11/Xp22.12]  [t(X;3)(p22;q13)]  
Fusion : MitelmanALCAM/YIF1B [3q13.11/19q13.2]  [t(3;19)(q13;q13)]  
Fusion: TCGAAHDC1 1p36.11 ALCAM 3q13.11 LUAD
Fusion: TCGAALCAM 3q13.11 EIF2A 3q25.1 BRCA
Fusion: TCGAALCAM 3q13.11 SH3KBP1 Xp22.12 BLCA
Fusion: TCGAALCAM 3q13.11 YIF1B 19q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALCAM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALCAM
dbVarALCAM
ClinVarALCAM
1000_GenomesALCAM 
Exome Variant ServerALCAM
ExAC (Exome Aggregation Consortium)ALCAM (select the gene name)
Genetic variants : HAPMAP214
Genomic Variants (DGV)ALCAM [DGVbeta]
DECIPHER (Syndromes)3:105085557-105295757  ENSG00000170017
CONAN: Copy Number AnalysisALCAM 
Mutations
ICGC Data PortalALCAM 
TCGA Data PortalALCAM 
Broad Tumor PortalALCAM
OASIS PortalALCAM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALCAM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALCAM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALCAM
DgiDB (Drug Gene Interaction Database)ALCAM
DoCM (Curated mutations)ALCAM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALCAM (select a term)
intoGenALCAM
Cancer3DALCAM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601662   
Orphanet
MedgenALCAM
Genetic Testing Registry ALCAM
NextProtQ13740 [Medical]
TSGene214
GENETestsALCAM
Huge Navigator ALCAM [HugePedia]
snp3D : Map Gene to Disease214
BioCentury BCIQALCAM
ClinGenALCAM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD214
Chemical/Pharm GKB GenePA24691
Clinical trialALCAM
Miscellaneous
canSAR (ICR)ALCAM (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALCAM
EVEXALCAM
GoPubMedALCAM
iHOPALCAM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:29 CET 2017

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