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ALDH3A1 (aldehyde dehydrogenase 3 family, member A1)

Identity

Other namesALDH3
ALDHIII
HGNC (Hugo) ALDH3A1
LocusID (NCBI) 218
Atlas_Id 374
Location 17p11.2
Location_base_pair Starts at 19641298 and ends at 19651746 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALDH3A1   405
Cards
Entrez_Gene (NCBI)ALDH3A1  218  aldehyde dehydrogenase 3 family, member A1
GeneCards (Weizmann)ALDH3A1
Ensembl hg19 (Hinxton)ENSG00000108602 [Gene_View]  chr17:19641298-19651746 [Contig_View]  ALDH3A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108602 [Gene_View]  chr17:19641298-19651746 [Contig_View]  ALDH3A1 [Vega]
ICGC DataPortalENSG00000108602
TCGA cBioPortalALDH3A1
AceView (NCBI)ALDH3A1
Genatlas (Paris)ALDH3A1
WikiGenes218
SOURCE (Princeton)ALDH3A1
Genomic and cartography
GoldenPath hg19 (UCSC)ALDH3A1  -     chr17:19641298-19651746 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALDH3A1  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblALDH3A1 - 17p11.2 [CytoView hg19]  ALDH3A1 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIALDH3A1 [Mapview hg19]  ALDH3A1 [Mapview hg38]
OMIM100660   
Gene and transcription
Genbank (Entrez)AK091272 AK093755 AK093877 AK225505 AK225513
RefSeq transcript (Entrez)NM_000691 NM_001135167 NM_001135168
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_012251 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)ALDH3A1
Cluster EST : UnigeneHs.531682 [ NCBI ]
CGAP (NCI)Hs.531682
Alternative Splicing : Fast-db (Paris)GSHG0013184
Alternative Splicing GalleryENSG00000108602
Gene ExpressionALDH3A1 [ NCBI-GEO ]     ALDH3A1 [ SEEK ]   ALDH3A1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30838 (Uniprot)
NextProtP30838  [Medical]
With graphics : InterProP30838
Splice isoforms : SwissVarP30838 (Swissvar)
Catalytic activity : Enzyme1.2.1.5 [ Enzyme-Expasy ]   1.2.1.51.2.1.5 [ IntEnz-EBI ]   1.2.1.5 [ BRENDA ]   1.2.1.5 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ALDEHYDE_DEHYDR_CYS (PS00070)    ALDEHYDE_DEHYDR_GLU (PS00687)   
Domains : Interpro (EBI)Ald_DH/histidinol_DH    Ald_DH_C    Ald_DH_CS_CYS    Ald_DH_CS_GLU    Ald_DH_N    Aldehyde_DH_dom    Aldehyde_DH_NAD(P)   
Related proteins : CluSTrP30838
Domain families : Pfam (Sanger)Aldedh (PF00171)   
Domain families : Pfam (NCBI)pfam00171   
DMDM Disease mutations218
Blocks (Seattle)P30838
PDB (SRS)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (PDBSum)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (IMB)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (RSDB)3SZA    3SZB    4H80    4L1O    4L2O   
Human Protein AtlasENSG00000108602
Peptide AtlasP30838
HPRD00004
IPIIPI00296183   IPI00902542   IPI00940201   IPI00654709   IPI00384883   IPI01009375   IPI00795549   IPI00796116   IPI00796823   
Protein Interaction databases
DIP (DOE-UCLA)P30838
IntAct (EBI)P30838
FunCoupENSG00000108602
BioGRIDALDH3A1
IntegromeDBALDH3A1
STRING (EMBL)ALDH3A1
Ontologies - Pathways
QuickGOP30838
Ontology : AmiGOresponse to hypoxia  3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  plasma membrane  cellular aldehyde metabolic process  aging  response to nutrient  alcohol dehydrogenase (NADP+) activity  positive regulation of cell proliferation  benzaldehyde dehydrogenase (NAD+) activity  response to drug  intracellular membrane-bounded organelle  response to glucocorticoid  response to cAMP  oxidation-reduction process  
Ontology : EGO-EBIresponse to hypoxia  3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  plasma membrane  cellular aldehyde metabolic process  aging  response to nutrient  alcohol dehydrogenase (NADP+) activity  positive regulation of cell proliferation  benzaldehyde dehydrogenase (NAD+) activity  response to drug  intracellular membrane-bounded organelle  response to glucocorticoid  response to cAMP  oxidation-reduction process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Histidine metabolism    Tyrosine metabolism    Phenylalanine metabolism    beta-Alanine metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
Protein Interaction DatabaseALDH3A1
DoCM (Curated mutations)ALDH3A1
Wikipedia pathwaysALDH3A1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerALDH3A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALDH3A1
dbVarALDH3A1
ClinVarALDH3A1
1000_GenomesALDH3A1 
Exome Variant ServerALDH3A1
SNP (GeneSNP Utah)ALDH3A1
SNP : HGBaseALDH3A1
Genetic variants : HAPMAPALDH3A1
Genomic Variants (DGV)ALDH3A1 [DGVbeta]
Mutations
ICGC Data PortalALDH3A1 
TCGA Data PortalALDH3A1 
Tumor PortalALDH3A1
Somatic Mutations in Cancer : COSMICALDH3A1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:19641298-19651746
CONAN: Copy Number AnalysisALDH3A1 
Mutations and Diseases : HGMDALDH3A1
OMIM100660   
MedgenALDH3A1
NextProtP30838 [Medical]
GENETestsALDH3A1
Disease Genetic AssociationALDH3A1
Huge Navigator ALDH3A1 [HugePedia]  ALDH3A1 [HugeCancerGEM]
snp3D : Map Gene to Disease218
DGIdb (Drug Gene Interaction db)ALDH3A1
General knowledge
Homologs : HomoloGeneALDH3A1
Homology/Alignments : Family Browser (UCSC)ALDH3A1
Phylogenetic Trees/Animal Genes : TreeFamALDH3A1
Chemical/Protein Interactions : CTD218
Chemical/Pharm GKB GenePA24697
Clinical trialALDH3A1
Cancer Resource (Charite)ENSG00000108602
Other databases
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
CoreMineALDH3A1
GoPubMedALDH3A1
iHOPALDH3A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 18:45:54 CEST 2015

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