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ALDH3A1 (aldehyde dehydrogenase 3 family member A1)

Identity

Alias_namesdimeric NADP-preferring
ALDH3
HGNC (Hugo) ALDH3A1
LocusID (NCBI) 218
Atlas_Id 374
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 19641298 and ends at 19651746 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ALDH3A1 (17p11.2) / ASPH (8q12.3)DDX55 (12q24.31) / ALDH3A1 (17p11.2)MSI2 (17q22) / ALDH3A1 (17p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALDH3A1   405
Cards
Entrez_Gene (NCBI)ALDH3A1  218  aldehyde dehydrogenase 3 family member A1
AliasesALDH3; ALDHIII
GeneCards (Weizmann)ALDH3A1
Ensembl hg19 (Hinxton)ENSG00000108602 [Gene_View]  chr17:19641298-19651746 [Contig_View]  ALDH3A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108602 [Gene_View]  chr17:19641298-19651746 [Contig_View]  ALDH3A1 [Vega]
ICGC DataPortalENSG00000108602
TCGA cBioPortalALDH3A1
AceView (NCBI)ALDH3A1
Genatlas (Paris)ALDH3A1
WikiGenes218
SOURCE (Princeton)ALDH3A1
Genetics Home Reference (NIH)ALDH3A1
Genomic and cartography
GoldenPath hg19 (UCSC)ALDH3A1  -     chr17:19641298-19651746 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALDH3A1  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblALDH3A1 - 17p11.2 [CytoView hg19]  ALDH3A1 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIALDH3A1 [Mapview hg19]  ALDH3A1 [Mapview hg38]
OMIM100660   
Gene and transcription
Genbank (Entrez)AK091272 AK093755 AK093877 AK225505 AK225513
RefSeq transcript (Entrez)NM_000691 NM_001135167 NM_001135168
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_012251 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)ALDH3A1
Cluster EST : UnigeneHs.531682 [ NCBI ]
CGAP (NCI)Hs.531682
Alternative Splicing GalleryENSG00000108602
Gene ExpressionALDH3A1 [ NCBI-GEO ]   ALDH3A1 [ EBI - ARRAY_EXPRESS ]   ALDH3A1 [ SEEK ]   ALDH3A1 [ MEM ]
Gene Expression Viewer (FireBrowse)ALDH3A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)218
GTEX Portal (Tissue expression)ALDH3A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30838   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30838  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30838
Splice isoforms : SwissVarP30838
Catalytic activity : Enzyme1.2.1.5 [ Enzyme-Expasy ]   1.2.1.51.2.1.5 [ IntEnz-EBI ]   1.2.1.5 [ BRENDA ]   1.2.1.5 [ KEGG ]   
PhosPhoSitePlusP30838
Domaine pattern : Prosite (Expaxy)ALDEHYDE_DEHYDR_CYS (PS00070)    ALDEHYDE_DEHYDR_GLU (PS00687)   
Domains : Interpro (EBI)Ald_DH/histidinol_DH    Ald_DH_C    Ald_DH_CS_CYS    Ald_DH_CS_GLU    Ald_DH_N    Aldehyde_DH_dom    Aldehyde_DH_NAD(P)   
Domain families : Pfam (Sanger)Aldedh (PF00171)   
Domain families : Pfam (NCBI)pfam00171   
Conserved Domain (NCBI)ALDH3A1
DMDM Disease mutations218
Blocks (Seattle)ALDH3A1
PDB (SRS)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (PDBSum)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (IMB)3SZA    3SZB    4H80    4L1O    4L2O   
PDB (RSDB)3SZA    3SZB    4H80    4L1O    4L2O   
Structural Biology KnowledgeBase3SZA    3SZB    4H80    4L1O    4L2O   
SCOP (Structural Classification of Proteins)3SZA    3SZB    4H80    4L1O    4L2O   
CATH (Classification of proteins structures)3SZA    3SZB    4H80    4L1O    4L2O   
SuperfamilyP30838
Human Protein AtlasENSG00000108602
Peptide AtlasP30838
HPRD00004
IPIIPI00296183   IPI00902542   IPI00940201   IPI00654709   IPI00384883   IPI01009375   IPI00795549   IPI00796116   IPI00796823   
Protein Interaction databases
DIP (DOE-UCLA)P30838
IntAct (EBI)P30838
FunCoupENSG00000108602
BioGRIDALDH3A1
STRING (EMBL)ALDH3A1
ZODIACALDH3A1
Ontologies - Pathways
QuickGOP30838
Ontology : AmiGOresponse to hypoxia  3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  protein binding  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  plasma membrane  cellular aldehyde metabolic process  xenobiotic metabolic process  aging  response to nutrient  alcohol dehydrogenase (NADP+) activity  positive regulation of cell proliferation  integral component of membrane  benzaldehyde dehydrogenase (NAD+) activity  response to drug  intracellular membrane-bounded organelle  response to glucocorticoid  response to cAMP  oxidation-reduction process  
Ontology : EGO-EBIresponse to hypoxia  3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  protein binding  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  plasma membrane  cellular aldehyde metabolic process  xenobiotic metabolic process  aging  response to nutrient  alcohol dehydrogenase (NADP+) activity  positive regulation of cell proliferation  integral component of membrane  benzaldehyde dehydrogenase (NAD+) activity  response to drug  intracellular membrane-bounded organelle  response to glucocorticoid  response to cAMP  oxidation-reduction process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Histidine metabolism    Tyrosine metabolism    Phenylalanine metabolism    beta-Alanine metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkALDH3A1
Atlas of Cancer Signalling NetworkALDH3A1
Wikipedia pathwaysALDH3A1
Orthology - Evolution
OrthoDB218
GeneTree (enSembl)ENSG00000108602
Phylogenetic Trees/Animal Genes : TreeFamALDH3A1
HOVERGENP30838
HOGENOMP30838
Homologs : HomoloGeneALDH3A1
Homology/Alignments : Family Browser (UCSC)ALDH3A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALDH3A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALDH3A1
dbVarALDH3A1
ClinVarALDH3A1
1000_GenomesALDH3A1 
Exome Variant ServerALDH3A1
ExAC (Exome Aggregation Consortium)ALDH3A1 (select the gene name)
Genetic variants : HAPMAP218
Genomic Variants (DGV)ALDH3A1 [DGVbeta]
DECIPHER (Syndromes)17:19641298-19651746  ENSG00000108602
CONAN: Copy Number AnalysisALDH3A1 
Mutations
ICGC Data PortalALDH3A1 
TCGA Data PortalALDH3A1 
Broad Tumor PortalALDH3A1
OASIS PortalALDH3A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALDH3A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALDH3A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALDH3A1
DgiDB (Drug Gene Interaction Database)ALDH3A1
DoCM (Curated mutations)ALDH3A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALDH3A1 (select a term)
intoGenALDH3A1
Cancer3DALDH3A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM100660   
Orphanet
MedgenALDH3A1
Genetic Testing Registry ALDH3A1
NextProtP30838 [Medical]
TSGene218
GENETestsALDH3A1
Huge Navigator ALDH3A1 [HugePedia]
snp3D : Map Gene to Disease218
BioCentury BCIQALDH3A1
ClinGenALDH3A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD218
Chemical/Pharm GKB GenePA24697
Clinical trialALDH3A1
Miscellaneous
canSAR (ICR)ALDH3A1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALDH3A1
EVEXALDH3A1
GoPubMedALDH3A1
iHOPALDH3A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:30:40 CET 2016

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