Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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ALDH3A2 (aldehyde dehydrogenase 3 family, member A2)

Identity

Other namesALDH10
FALDH
SLS
HGNC (Hugo) ALDH3A2
LocusID (NCBI) 224
Location 17p11.2
Location_base_pair Starts at 19552064 and ends at 19580908 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALDH3A2   403
Cards
Entrez_Gene (NCBI)ALDH3A2  224  aldehyde dehydrogenase 3 family, member A2
GeneCards (Weizmann)ALDH3A2
Ensembl hg19 (Hinxton)ENSG00000072210 [Gene_View]  chr17:19552064-19580908 [Contig_View]  ALDH3A2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000072210 [Gene_View]  chr17:19552064-19580908 [Contig_View]  ALDH3A2 [Vega]
ICGC DataPortalENSG00000072210
cBioPortalALDH3A2
AceView (NCBI)ALDH3A2
Genatlas (Paris)ALDH3A2
WikiGenes224
SOURCE (Princeton)ALDH3A2
Genomic and cartography
GoldenPath hg19 (UCSC)ALDH3A2  -     chr17:19552064-19580908 +  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALDH3A2  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblALDH3A2 - 17p11.2 [CytoView hg19]  ALDH3A2 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIALDH3A2 [Mapview hg19]  ALDH3A2 [Mapview hg38]
OMIM270200   609523   
Gene and transcription
Genbank (Entrez)AB208894 AK000858 AK025677 AK123877 AK292381
RefSeq transcript (Entrez)NM_000382 NM_001031806
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_007095 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)ALDH3A2
Cluster EST : UnigeneHs.499886 [ NCBI ]
CGAP (NCI)Hs.499886
Alternative Splicing : Fast-db (Paris)GSHG0012303
Alternative Splicing GalleryENSG00000072210
Gene ExpressionALDH3A2 [ NCBI-GEO ]     ALDH3A2 [ SEEK ]   ALDH3A2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51648 (Uniprot)
NextProtP51648  [Medical]
With graphics : InterProP51648
Splice isoforms : SwissVarP51648 (Swissvar)
Catalytic activity : Enzyme1.2.1.3 [ Enzyme-Expasy ]   1.2.1.31.2.1.3 [ IntEnz-EBI ]   1.2.1.3 [ BRENDA ]   1.2.1.3 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ALDEHYDE_DEHYDR_CYS (PS00070)    ALDEHYDE_DEHYDR_GLU (PS00687)   
Domains : Interpro (EBI)Ald_DH/histidinol_DH    Ald_DH_C    Ald_DH_CS_CYS    Ald_DH_CS_GLU    Ald_DH_N    Aldehyde_DH_dom    Aldehyde_DH_NAD(P)   
Related proteins : CluSTrP51648
Domain families : Pfam (Sanger)Aldedh (PF00171)   
Domain families : Pfam (NCBI)pfam00171   
DMDM Disease mutations224
Blocks (Seattle)P51648
PDB (SRS)4QGK   
PDB (PDBSum)4QGK   
PDB (IMB)4QGK   
PDB (RSDB)4QGK   
Human Protein AtlasENSG00000072210
Peptide AtlasP51648
HPRD07188
IPIIPI00333619   IPI00394758   IPI00789301   
Protein Interaction databases
DIP (DOE-UCLA)P51648
IntAct (EBI)P51648
FunCoupENSG00000072210
BioGRIDALDH3A2
IntegromeDBALDH3A2
STRING (EMBL)ALDH3A2
Ontologies - Pathways
QuickGOP51648
Ontology : AmiGO3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  mitochondrial inner membrane  peroxisome  endoplasmic reticulum membrane  cellular aldehyde metabolic process  cellular aldehyde metabolic process  sesquiterpenoid metabolic process  central nervous system development  peripheral nervous system development  epidermis development  integral component of membrane  phytol metabolic process  intracellular membrane-bounded organelle  long-chain-alcohol oxidase activity  long-chain-aldehyde dehydrogenase activity  medium-chain-aldehyde dehydrogenase activity  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBI3-chloroallyl aldehyde dehydrogenase activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase (NAD) activity  aldehyde dehydrogenase [NAD(P)+] activity  mitochondrial inner membrane  peroxisome  endoplasmic reticulum membrane  cellular aldehyde metabolic process  cellular aldehyde metabolic process  sesquiterpenoid metabolic process  central nervous system development  peripheral nervous system development  epidermis development  integral component of membrane  phytol metabolic process  intracellular membrane-bounded organelle  long-chain-alcohol oxidase activity  long-chain-aldehyde dehydrogenase activity  medium-chain-aldehyde dehydrogenase activity  oxidation-reduction process  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Pentose and glucuronate interconversions    Ascorbate and aldarate metabolism    Fatty acid degradation    Valine, leucine and isoleucine degradation    Lysine degradation    Arginine and proline metabolism    Histidine metabolism    Tryptophan metabolism    beta-Alanine metabolism    Glycerolipid metabolism    Pyruvate metabolism    Propanoate metabolism   
Protein Interaction DatabaseALDH3A2
DoCM (Curated mutations)ALDH3A2
Wikipedia pathwaysALDH3A2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerALDH3A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALDH3A2
dbVarALDH3A2
ClinVarALDH3A2
1000_GenomesALDH3A2 
Exome Variant ServerALDH3A2
SNP (GeneSNP Utah)ALDH3A2
SNP : HGBaseALDH3A2
Genetic variants : HAPMAPALDH3A2
Genomic Variants (DGV)ALDH3A2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000072210 
Somatic Mutations in Cancer : COSMICALDH3A2 
CONAN: Copy Number AnalysisALDH3A2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:19552064-19580908
Mutations and Diseases : HGMDALDH3A2
OMIM270200    609523   
MedgenALDH3A2
NextProtP51648 [Medical]
GENETestsALDH3A2
Disease Genetic AssociationALDH3A2
Huge Navigator ALDH3A2 [HugePedia]  ALDH3A2 [HugeCancerGEM]
snp3D : Map Gene to Disease224
DGIdb (Drug Gene Interaction db)ALDH3A2
General knowledge
Homologs : HomoloGeneALDH3A2
Homology/Alignments : Family Browser (UCSC)ALDH3A2
Phylogenetic Trees/Animal Genes : TreeFamALDH3A2
Chemical/Protein Interactions : CTD224
Chemical/Pharm GKB GenePA24698
Clinical trialALDH3A2
Cancer Resource (Charite)ENSG00000072210
Other databases
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
CoreMineALDH3A2
GoPubMedALDH3A2
iHOPALDH3A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 14:41:40 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.