ALDH4A1 (aldehyde dehydrogenase 4 family member A1)

2007-04-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
ALDH4,P5CD,P5CDh
FUSION GENES

Other Information

Locus ID:

NCBI: 8659
MIM: 606811
HGNC: 406
Ensembl: ENSG00000159423

Variants:

dbSNP: 8659
ClinVar: 8659
TCGA: ENSG00000159423
COSMIC: ALDH4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159423ENST00000290597P30038
ENSG00000159423ENST00000290597A0A024RAD8
ENSG00000159423ENST00000375341P30038
ENSG00000159423ENST00000375341A0A024RAD8
ENSG00000159423ENST00000432718Q5TF55
ENSG00000159423ENST00000538309P30038
ENSG00000159423ENST00000538839P30038

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Proline catabolismREACTOMER-HSA-70688
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149861712004Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.85
149861712004Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
225166122012The three-dimensional structural basis of type II hyperprolinemia.26
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17

Citation

Dessen P

ALDH4A1 (aldehyde dehydrogenase 4 family member A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46989/aldh4a1