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ALDH9A1 (aldehyde dehydrogenase 9 family member A1)

Identity

Alias (NCBI)ALDH4
ALDH7
ALDH9
E3
TMABA-DH
TMABADH
TMABALDH
HGNC (Hugo) ALDH9A1
HGNC Alias symbE3
HGNC Previous nameALDH7
 ALDH4
 ALDH9
HGNC Previous namealdehyde dehydrogenase 9 family, member A1
LocusID (NCBI) 223
Atlas_Id 47245
Location 1q24.1  [Link to chromosome band 1q24]
Location_base_pair Starts at 165662216 and ends at 165698562 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALDH9A1 (1q24.1) / NME7 (1q24.2)ALDH9A1 (1q24.1) / PSAP (10q22.1)LOC100507412 (-) / ALDH9A1 (1q24.1)
ALDH9A1 1q24.1 / NME7 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ALDH9A1   412
Cards
Entrez_Gene (NCBI)ALDH9A1    aldehyde dehydrogenase 9 family member A1
AliasesALDH4; ALDH7; ALDH9; E3; 
TMABA-DH; TMABADH; TMABALDH
GeneCards (Weizmann)ALDH9A1
Ensembl hg19 (Hinxton)ENSG00000143149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143149 [Gene_View]  ENSG00000143149 [Sequence]  chr1:165662216-165698562 [Contig_View]  ALDH9A1 [Vega]
ICGC DataPortalENSG00000143149
TCGA cBioPortalALDH9A1
AceView (NCBI)ALDH9A1
Genatlas (Paris)ALDH9A1
SOURCE (Princeton)ALDH9A1
Genetics Home Reference (NIH)ALDH9A1
Genomic and cartography
GoldenPath hg38 (UCSC)ALDH9A1  -     chr1:165662216-165698562 -  1q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALDH9A1  -     1q24.1   [Description]    (hg19-Feb_2009)
GoldenPathALDH9A1 - 1q24.1 [CytoView hg19]  ALDH9A1 - 1q24.1 [CytoView hg38]
ImmunoBaseENSG00000143149
Genome Data Viewer NCBIALDH9A1 [Mapview hg19]  
OMIM602733   
Gene and transcription
Genbank (Entrez)AF172093 AK293520 AK301767 AK302183 AK302191
RefSeq transcript (Entrez)NM_000696 NM_001365774
Consensus coding sequences : CCDS (NCBI)ALDH9A1
Gene ExpressionALDH9A1 [ NCBI-GEO ]   ALDH9A1 [ EBI - ARRAY_EXPRESS ]   ALDH9A1 [ SEEK ]   ALDH9A1 [ MEM ]
Gene Expression Viewer (FireBrowse)ALDH9A1 [ Firebrowse - Broad ]
GenevisibleExpression of ALDH9A1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)223
GTEX Portal (Tissue expression)ALDH9A1
Human Protein AtlasENSG00000143149-ALDH9A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49189   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49189  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49189
PhosPhoSitePlusP49189
Domaine pattern : Prosite (Expaxy)ALDEHYDE_DEHYDR_CYS (PS00070)    ALDEHYDE_DEHYDR_GLU (PS00687)   
Domains : Interpro (EBI)Ald_DH/histidinol_DH    Ald_DH_C    Ald_DH_CS_CYS    Ald_DH_CS_GLU    Ald_DH_N    Aldehyde_DH_dom   
Domain families : Pfam (Sanger)Aldedh (PF00171)   
Domain families : Pfam (NCBI)pfam00171   
Conserved Domain (NCBI)ALDH9A1
PDB (RSDB)6QAK    6QAO    6QAP    6VR6    6VWF   
PDB Europe6QAK    6QAO    6QAP    6VR6    6VWF   
PDB (PDBSum)6QAK    6QAO    6QAP    6VR6    6VWF   
PDB (IMB)6QAK    6QAO    6QAP    6VR6    6VWF   
Structural Biology KnowledgeBase6QAK    6QAO    6QAP    6VR6    6VWF   
SCOP (Structural Classification of Proteins)6QAK    6QAO    6QAP    6VR6    6VWF   
CATH (Classification of proteins structures)6QAK    6QAO    6QAP    6VR6    6VWF   
SuperfamilyP49189
AlphaFold pdb e-kbP49189   
Human Protein Atlas [tissue]ENSG00000143149-ALDH9A1 [tissue]
HPRD04109
Protein Interaction databases
DIP (DOE-UCLA)P49189
IntAct (EBI)P49189
BioGRIDALDH9A1
STRING (EMBL)ALDH9A1
ZODIACALDH9A1
Ontologies - Pathways
QuickGOP49189
Ontology : AmiGOaldehyde dehydrogenase (NAD+) activity  aldehyde dehydrogenase (NAD+) activity  cytoplasm  cytosol  cellular aldehyde metabolic process  aminobutyraldehyde dehydrogenase activity  aminobutyraldehyde dehydrogenase activity  1-pyrroline dehydrogenase activity  neurotransmitter biosynthetic process  hormone metabolic process  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity  carnitine biosynthetic process  carnitine biosynthetic process  4-trimethylammoniobutyraldehyde dehydrogenase activity  4-trimethylammoniobutyraldehyde dehydrogenase activity  protein homotetramerization  extracellular exosome  
Ontology : EGO-EBIaldehyde dehydrogenase (NAD+) activity  aldehyde dehydrogenase (NAD+) activity  cytoplasm  cytosol  cellular aldehyde metabolic process  aminobutyraldehyde dehydrogenase activity  aminobutyraldehyde dehydrogenase activity  1-pyrroline dehydrogenase activity  neurotransmitter biosynthetic process  hormone metabolic process  glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity  carnitine biosynthetic process  carnitine biosynthetic process  4-trimethylammoniobutyraldehyde dehydrogenase activity  4-trimethylammoniobutyraldehyde dehydrogenase activity  protein homotetramerization  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Ascorbate and aldarate metabolism    Fatty acid degradation    Valine, leucine and isoleucine degradation    Lysine degradation    Arginine and proline metabolism    Histidine metabolism    Tryptophan metabolism    beta-Alanine metabolism    Glycerolipid metabolism    Pyruvate metabolism    Propanoate metabolism   
NDEx NetworkALDH9A1
Atlas of Cancer Signalling NetworkALDH9A1
Wikipedia pathwaysALDH9A1
Orthology - Evolution
OrthoDB223
GeneTree (enSembl)ENSG00000143149
Phylogenetic Trees/Animal Genes : TreeFamALDH9A1
Homologs : HomoloGeneALDH9A1
Homology/Alignments : Family Browser (UCSC)ALDH9A1
Gene fusions - Rearrangements
Fusion : MitelmanALDH9A1/NME7 [1q24.1/1q24.2]  
Fusion : QuiverALDH9A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALDH9A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALDH9A1
dbVarALDH9A1
ClinVarALDH9A1
MonarchALDH9A1
1000_GenomesALDH9A1 
Exome Variant ServerALDH9A1
GNOMAD BrowserENSG00000143149
Varsome BrowserALDH9A1
ACMGALDH9A1 variants
VarityP49189
Genomic Variants (DGV)ALDH9A1 [DGVbeta]
DECIPHERALDH9A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALDH9A1 
Mutations
ICGC Data PortalALDH9A1 
TCGA Data PortalALDH9A1 
Broad Tumor PortalALDH9A1
OASIS PortalALDH9A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALDH9A1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALDH9A1
Mutations and Diseases : HGMDALDH9A1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaALDH9A1
DgiDB (Drug Gene Interaction Database)ALDH9A1
DoCM (Curated mutations)ALDH9A1
CIViC (Clinical Interpretations of Variants in Cancer)ALDH9A1
Cancer3DALDH9A1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602733   
Orphanet
DisGeNETALDH9A1
MedgenALDH9A1
Genetic Testing Registry ALDH9A1
NextProtP49189 [Medical]
GENETestsALDH9A1
Target ValidationALDH9A1
Huge Navigator ALDH9A1 [HugePedia]
ClinGenALDH9A1
Clinical trials, drugs, therapy
MyCancerGenomeALDH9A1
Protein Interactions : CTDALDH9A1
Pharm GKB GenePA24706
PharosP49189
Clinical trialALDH9A1
Miscellaneous
canSAR (ICR)ALDH9A1
HarmonizomeALDH9A1
DataMed IndexALDH9A1
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALDH9A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:05 CEST 2021

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