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ALDOC (aldolase, fructose-bisphosphate C)

Identity

Alias_namesaldolase C, fructose-bisphosphate
Other aliasALDC
HGNC (Hugo) ALDOC
LocusID (NCBI) 230
Atlas_Id 47441
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28573120 and ends at 28576895 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALDOC (17q11.2) / KIF3A (5q31.1)ALDOC (17q11.2) / MAN1A2 (1p12)GAD1 (2q31.1) / ALDOC (17q11.2)
MAN1A2 (1p12) / ALDOC (17q11.2)MARK2 (11q13.1) / ALDOC (17q11.2)SYN1 (Xp11.23) / ALDOC (17q11.2)
TRAK1 (3p22.1) / ALDOC (17q11.2)WNK1 (12p13.33) / ALDOC (17q11.2)ALDOC 17q11.2 / KIF3A 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(1;17)(p12;q11) MAN1A2/ALDOC
t(1;17)(p12;q11) ALDOC/MAN1A2
t(5;17)(q31;q11) ALDOC/KIF3A

External links

Nomenclature
HGNC (Hugo)ALDOC   418
Cards
Entrez_Gene (NCBI)ALDOC  230  aldolase, fructose-bisphosphate C
AliasesALDC
GeneCards (Weizmann)ALDOC
Ensembl hg19 (Hinxton)ENSG00000109107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109107 [Gene_View]  ENSG00000109107 [Sequence]  chr17:28573120-28576895 [Contig_View]  ALDOC [Vega]
ICGC DataPortalENSG00000109107
TCGA cBioPortalALDOC
AceView (NCBI)ALDOC
Genatlas (Paris)ALDOC
WikiGenes230
SOURCE (Princeton)ALDOC
Genetics Home Reference (NIH)ALDOC
Genomic and cartography
GoldenPath hg38 (UCSC)ALDOC  -     chr17:28573120-28576895 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALDOC  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathALDOC - 17q11.2 [CytoView hg19]  ALDOC - 17q11.2 [CytoView hg38]
Genome Data Viewer NCBIALDOC [Mapview hg19]  
OMIM103870   
Gene and transcription
Genbank (Entrez)AF054987 AK293453 AK293623 AK293693 AK294091
RefSeq transcript (Entrez)NM_005165
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALDOC
Alternative Splicing GalleryENSG00000109107
Gene ExpressionALDOC [ NCBI-GEO ]   ALDOC [ EBI - ARRAY_EXPRESS ]   ALDOC [ SEEK ]   ALDOC [ MEM ]
Gene Expression Viewer (FireBrowse)ALDOC [ Firebrowse - Broad ]
GenevisibleExpression of ALDOC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)230
GTEX Portal (Tissue expression)ALDOC
Human Protein AtlasENSG00000109107-ALDOC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09972   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09972  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09972
Splice isoforms : SwissVarP09972
Catalytic activity : Enzyme4.1.2.13 [ Enzyme-Expasy ]   4.1.2.134.1.2.13 [ IntEnz-EBI ]   4.1.2.13 [ BRENDA ]   4.1.2.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP09972
Domaine pattern : Prosite (Expaxy)ALDOLASE_CLASS_I (PS00158)   
Domains : Interpro (EBI)Aldolase_I_AS    Aldolase_TIM    FBA_I   
Domain families : Pfam (Sanger)Glycolytic (PF00274)   
Domain families : Pfam (NCBI)pfam00274   
Conserved Domain (NCBI)ALDOC
DMDM Disease mutations230
PDB (RSDB)1XFB   
PDB Europe1XFB   
PDB (PDBSum)1XFB   
PDB (IMB)1XFB   
Structural Biology KnowledgeBase1XFB   
SCOP (Structural Classification of Proteins)1XFB   
CATH (Classification of proteins structures)1XFB   
SuperfamilyP09972
Human Protein Atlas [tissue]ENSG00000109107-ALDOC [tissue]
Peptide AtlasP09972
HPRD02386
IPIIPI00922081   IPI00418262   IPI00792375   IPI00789171   
Protein Interaction databases
DIP (DOE-UCLA)P09972
IntAct (EBI)P09972
FunCoupENSG00000109107
BioGRIDALDOC
STRING (EMBL)ALDOC
ZODIACALDOC
Ontologies - Pathways
QuickGOP09972
Ontology : AmiGOfructose-bisphosphate aldolase activity  fructose-bisphosphate aldolase activity  protein binding  extracellular region  cytosol  cytosol  cytoskeleton  fructose metabolic process  gluconeogenesis  glycolytic process  cytoskeletal protein binding  fructose 1,6-bisphosphate metabolic process  fructose 1,6-bisphosphate metabolic process  epithelial cell differentiation  secretory granule lumen  neutrophil degranulation  canonical glycolysis  extracellular exosome  tertiary granule lumen  ficolin-1-rich granule lumen  
Ontology : EGO-EBIfructose-bisphosphate aldolase activity  fructose-bisphosphate aldolase activity  protein binding  extracellular region  cytosol  cytosol  cytoskeleton  fructose metabolic process  gluconeogenesis  glycolytic process  cytoskeletal protein binding  fructose 1,6-bisphosphate metabolic process  fructose 1,6-bisphosphate metabolic process  epithelial cell differentiation  secretory granule lumen  neutrophil degranulation  canonical glycolysis  extracellular exosome  tertiary granule lumen  ficolin-1-rich granule lumen  
Pathways : KEGGGlycolysis / Gluconeogenesis    Pentose phosphate pathway    Fructose and mannose metabolism   
NDEx NetworkALDOC
Atlas of Cancer Signalling NetworkALDOC
Wikipedia pathwaysALDOC
Orthology - Evolution
OrthoDB230
GeneTree (enSembl)ENSG00000109107
Phylogenetic Trees/Animal Genes : TreeFamALDOC
HOGENOMP09972
Homologs : HomoloGeneALDOC
Homology/Alignments : Family Browser (UCSC)ALDOC
Gene fusions - Rearrangements
Fusion : MitelmanALDOC/KIF3A [17q11.2/5q31.1]  
Fusion : MitelmanALDOC/MAN1A2 [17q11.2/1p12]  
Fusion : MitelmanMAN1A2/ALDOC [1p12/17q11.2]  
Fusion PortalALDOC 17q11.2 KIF3A 5q31.1 LGG
Fusion : QuiverALDOC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALDOC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALDOC
dbVarALDOC
ClinVarALDOC
1000_GenomesALDOC 
Exome Variant ServerALDOC
GNOMAD BrowserENSG00000109107
Varsome BrowserALDOC
Genetic variants : HAPMAP230
Genomic Variants (DGV)ALDOC [DGVbeta]
DECIPHERALDOC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALDOC 
Mutations
ICGC Data PortalALDOC 
TCGA Data PortalALDOC 
Broad Tumor PortalALDOC
OASIS PortalALDOC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALDOC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALDOC
Mutations and Diseases : HGMDALDOC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect ALDOC
DgiDB (Drug Gene Interaction Database)ALDOC
DoCM (Curated mutations)ALDOC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALDOC (select a term)
intoGenALDOC
Cancer3DALDOC (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103870   
Orphanet
DisGeNETALDOC
MedgenALDOC
Genetic Testing Registry ALDOC
NextProtP09972 [Medical]
TSGene230
GENETestsALDOC
Open Targets GeneticsENSG00000109107  [validation]
snp3D : Map Gene to Disease230
BioCentury BCIQALDOC
ClinGenALDOC
Clinical trials, drugs, therapy
Protein Interactions : CTD230
Pharm GKB GenePA24711
Clinical trialALDOC
Miscellaneous
canSAR (ICR)ALDOC (select the gene name)
HarmonizomeALDOC
DataMed IndexALDOC
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALDOC
EVEXALDOC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:38:34 CEST 2020
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