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ALG2 (ALG2, alpha-1,3/1,6-mannosyltransferase)

Identity

Alias_namesasparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
Alias_symbol (synonym)CDGIi
FLJ14511
hALPG2
NET38
Other aliasCDG1I
CMS14
CMSTA3
HGNC (Hugo) ALG2
LocusID (NCBI) 85365
Atlas_Id 50934
Location 9q22.33  [Link to chromosome band 9q22]
Location_base_pair Starts at 99216425 and ends at 99221964 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TNRC6C (17q25.3) / ALG2 (9q22.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALG2   23159
Cards
Entrez_Gene (NCBI)ALG2  85365  ALG2, alpha-1,3/1,6-mannosyltransferase
AliasesCDG1I; CDGIi; CMS14; CMSTA3; 
NET38; hALPG2
GeneCards (Weizmann)ALG2
Ensembl hg19 (Hinxton)ENSG00000119523 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119523 [Gene_View]  chr9:99216425-99221964 [Contig_View]  ALG2 [Vega]
ICGC DataPortalENSG00000119523
TCGA cBioPortalALG2
AceView (NCBI)ALG2
Genatlas (Paris)ALG2
WikiGenes85365
SOURCE (Princeton)ALG2
Genetics Home Reference (NIH)ALG2
Genomic and cartography
GoldenPath hg38 (UCSC)ALG2  -     chr9:99216425-99221964 -  9q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALG2  -     9q22.33   [Description]    (hg19-Feb_2009)
EnsemblALG2 - 9q22.33 [CytoView hg19]  ALG2 - 9q22.33 [CytoView hg38]
Mapping of homologs : NCBIALG2 [Mapview hg19]  ALG2 [Mapview hg38]
OMIM607905   607906   616228   
Gene and transcription
Genbank (Entrez)AA017454 AB161356 AK027417 AK027814 AK074704
RefSeq transcript (Entrez)NM_033087 NM_197973
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALG2
Cluster EST : UnigeneHs.40919 [ NCBI ]
CGAP (NCI)Hs.40919
Alternative Splicing GalleryENSG00000119523
Gene ExpressionALG2 [ NCBI-GEO ]   ALG2 [ EBI - ARRAY_EXPRESS ]   ALG2 [ SEEK ]   ALG2 [ MEM ]
Gene Expression Viewer (FireBrowse)ALG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85365
GTEX Portal (Tissue expression)ALG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H553   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H553  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H553
Splice isoforms : SwissVarQ9H553
Catalytic activity : Enzyme2.4.1.132 [ Enzyme-Expasy ]   2.4.1.1322.4.1.132 [ IntEnz-EBI ]   2.4.1.132 [ BRENDA ]   2.4.1.132 [ KEGG ]   
PhosPhoSitePlusQ9H553
Domains : Interpro (EBI)Glyco_trans_1    Glyco_trans_4-like_N   
Domain families : Pfam (Sanger)Glyco_transf_4 (PF13439)    Glycos_transf_1 (PF00534)   
Domain families : Pfam (NCBI)pfam13439    pfam00534   
Conserved Domain (NCBI)ALG2
DMDM Disease mutations85365
Blocks (Seattle)ALG2
SuperfamilyQ9H553
Human Protein AtlasENSG00000119523
Peptide AtlasQ9H553
HPRD09716
IPIIPI00386072   IPI00171443   
Protein Interaction databases
DIP (DOE-UCLA)Q9H553
IntAct (EBI)Q9H553
FunCoupENSG00000119523
BioGRIDALG2
STRING (EMBL)ALG2
ZODIACALG2
Ontologies - Pathways
QuickGOQ9H553
Ontology : AmiGOalpha-1,3-mannosyltransferase activity  alpha-1,3-mannosyltransferase activity  GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  endoplasmic reticulum membrane  dolichol-linked oligosaccharide biosynthetic process  dolichol-linked oligosaccharide biosynthetic process  membrane  integral component of membrane  protein glycosylation in endoplasmic reticulum  protein heterodimerization activity  protein N-terminus binding  calcium-dependent protein binding  calcium-dependent protein binding  perinuclear region of cytoplasm  response to calcium ion  mannosylation  GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity  
Ontology : EGO-EBIalpha-1,3-mannosyltransferase activity  alpha-1,3-mannosyltransferase activity  GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  endoplasmic reticulum membrane  dolichol-linked oligosaccharide biosynthetic process  dolichol-linked oligosaccharide biosynthetic process  membrane  integral component of membrane  protein glycosylation in endoplasmic reticulum  protein heterodimerization activity  protein N-terminus binding  calcium-dependent protein binding  calcium-dependent protein binding  perinuclear region of cytoplasm  response to calcium ion  mannosylation  GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkALG2
Atlas of Cancer Signalling NetworkALG2
Wikipedia pathwaysALG2
Orthology - Evolution
OrthoDB85365
GeneTree (enSembl)ENSG00000119523
Phylogenetic Trees/Animal Genes : TreeFamALG2
HOVERGENQ9H553
HOGENOMQ9H553
Homologs : HomoloGeneALG2
Homology/Alignments : Family Browser (UCSC)ALG2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALG2
dbVarALG2
ClinVarALG2
1000_GenomesALG2 
Exome Variant ServerALG2
ExAC (Exome Aggregation Consortium)ALG2 (select the gene name)
Genetic variants : HAPMAP85365
Genomic Variants (DGV)ALG2 [DGVbeta]
DECIPHERALG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALG2 
Mutations
ICGC Data PortalALG2 
TCGA Data PortalALG2 
Broad Tumor PortalALG2
OASIS PortalALG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ALG2
DgiDB (Drug Gene Interaction Database)ALG2
DoCM (Curated mutations)ALG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALG2 (select a term)
intoGenALG2
Cancer3DALG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607905    607906    616228   
Orphanet22137    11352   
MedgenALG2
Genetic Testing Registry ALG2
NextProtQ9H553 [Medical]
TSGene85365
GENETestsALG2
Huge Navigator ALG2 [HugePedia]
snp3D : Map Gene to Disease85365
BioCentury BCIQALG2
ClinGenALG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85365
Chemical/Pharm GKB GenePA134956849
Clinical trialALG2
Miscellaneous
canSAR (ICR)ALG2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALG2
EVEXALG2
GoPubMedALG2
iHOPALG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:42 CEST 2017

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