Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ALG5 (ALG5, dolichyl-phosphate beta-glucosyltransferase)

Identity

Alias_namesasparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)
Alias_symbol (synonym)bA421P11.2
Other alias
HGNC (Hugo) ALG5
LocusID (NCBI) 29880
Atlas_Id 54117
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 36949771 and ends at 36999367 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG5 (13q13.3) / PIGU (20q11.22)ALG5 (13q13.3) / PRKCA (17q24.2)ALG5 (13q13.3) / WBSCR17 (7q11.22)
PIGU (20q11.22) / ALG5 (13q13.3)ALG5 13q13.3 / WBSCR17 7q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(13;20)(q13;q11) ALG5/PIGU
t(13;20)(q13;q11) PIGU/ALG5

External links

Nomenclature
HGNC (Hugo)ALG5   20266
Cards
Entrez_Gene (NCBI)ALG5  29880  ALG5, dolichyl-phosphate beta-glucosyltransferase
AliasesbA421P11.2
GeneCards (Weizmann)ALG5
Ensembl hg19 (Hinxton)ENSG00000120697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120697 [Gene_View]  ENSG00000120697 [Sequence]  chr13:36949771-36999367 [Contig_View]  ALG5 [Vega]
ICGC DataPortalENSG00000120697
TCGA cBioPortalALG5
AceView (NCBI)ALG5
Genatlas (Paris)ALG5
WikiGenes29880
SOURCE (Princeton)ALG5
Genetics Home Reference (NIH)ALG5
Genomic and cartography
GoldenPath hg38 (UCSC)ALG5  -     chr13:36949771-36999367 -  13q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALG5  -     13q13.3   [Description]    (hg19-Feb_2009)
ALG5 - 13q13.3 [CytoView hg19]  ALG5 - 13q13.3 [CytoView hg38]
Mapping of homologs : NCBIALG5 [Mapview hg19]  ALG5 [Mapview hg38]
OMIM604565   
Gene and transcription
Genbank (Entrez)AF088028 AF102850 AF161498 AF183413 AI027225
RefSeq transcript (Entrez)NM_001142364 NM_013338
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALG5
Cluster EST : UnigeneHs.507769 [ NCBI ]
CGAP (NCI)Hs.507769
Alternative Splicing GalleryENSG00000120697
Gene ExpressionALG5 [ NCBI-GEO ]   ALG5 [ EBI - ARRAY_EXPRESS ]   ALG5 [ SEEK ]   ALG5 [ MEM ]
Gene Expression Viewer (FireBrowse)ALG5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29880
GTEX Portal (Tissue expression)ALG5
Human Protein AtlasENSG00000120697-ALG5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y673   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y673  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y673
Splice isoforms : SwissVarQ9Y673
Catalytic activity : Enzyme2.4.1.117 [ Enzyme-Expasy ]   2.4.1.1172.4.1.117 [ IntEnz-EBI ]   2.4.1.117 [ BRENDA ]   2.4.1.117 [ KEGG ]   
PhosPhoSitePlusQ9Y673
Domains : Interpro (EBI)DPG_synthase    Glyco_trans_2-like    Nucleotide-diphossugar_trans   
Domain families : Pfam (Sanger)Glycos_transf_2 (PF00535)   
Domain families : Pfam (NCBI)pfam00535   
Conserved Domain (NCBI)ALG5
DMDM Disease mutations29880
Blocks (Seattle)ALG5
SuperfamilyQ9Y673
Human Protein Atlas [tissue]ENSG00000120697-ALG5 [tissue]
Peptide AtlasQ9Y673
HPRD05193
IPIIPI00002506   IPI00909046   IPI00909749   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y673
IntAct (EBI)Q9Y673
FunCoupENSG00000120697
BioGRIDALG5
STRING (EMBL)ALG5
ZODIACALG5
Ontologies - Pathways
QuickGOQ9Y673
Ontology : AmiGOoligosaccharyl transferase activity  dolichyl-phosphate beta-glucosyltransferase activity  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein glycosylation  protein N-linked glycosylation  determination of left/right symmetry  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  
Ontology : EGO-EBIoligosaccharyl transferase activity  dolichyl-phosphate beta-glucosyltransferase activity  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein glycosylation  protein N-linked glycosylation  determination of left/right symmetry  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkALG5
Atlas of Cancer Signalling NetworkALG5
Wikipedia pathwaysALG5
Orthology - Evolution
OrthoDB29880
GeneTree (enSembl)ENSG00000120697
Phylogenetic Trees/Animal Genes : TreeFamALG5
HOGENOMQ9Y673
Homologs : HomoloGeneALG5
Homology/Alignments : Family Browser (UCSC)ALG5
Gene fusions - Rearrangements
Fusion : MitelmanALG5/PIGU [13q13.3/20q11.22]  
Fusion : MitelmanALG5/WBSCR17 [13q13.3/7q11.22]  [t(7;13)(q11;q13)]  
Fusion : MitelmanPIGU/ALG5 [20q11.22/13q13.3]  [t(13;20)(q13;q11)]  
Fusion PortalALG5 13q13.3 WBSCR17 7q11.22 BLCA
Fusion : QuiverALG5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALG5
dbVarALG5
ClinVarALG5
1000_GenomesALG5 
Exome Variant ServerALG5
ExAC (Exome Aggregation Consortium)ENSG00000120697
GNOMAD BrowserENSG00000120697
Varsome BrowserALG5
Genetic variants : HAPMAP29880
Genomic Variants (DGV)ALG5 [DGVbeta]
DECIPHERALG5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALG5 
Mutations
ICGC Data PortalALG5 
TCGA Data PortalALG5 
Broad Tumor PortalALG5
OASIS PortalALG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALG5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALG5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALG5
DgiDB (Drug Gene Interaction Database)ALG5
DoCM (Curated mutations)ALG5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALG5 (select a term)
intoGenALG5
Cancer3DALG5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604565   
Orphanet
DisGeNETALG5
MedgenALG5
Genetic Testing Registry ALG5
NextProtQ9Y673 [Medical]
TSGene29880
GENETestsALG5
Target ValidationALG5
Huge Navigator ALG5 [HugePedia]
snp3D : Map Gene to Disease29880
BioCentury BCIQALG5
ClinGenALG5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29880
Chemical/Pharm GKB GenePA134977026
Clinical trialALG5
Miscellaneous
canSAR (ICR)ALG5 (select the gene name)
DataMed IndexALG5
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALG5
EVEXALG5
GoPubMedALG5
iHOPALG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 21 15:35:40 CET 2019
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