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ALG6 (ALG6 alpha-1,3-glucosyltransferase)

Identity

Alias (NCBI)CDG1C
HGNC (Hugo) ALG6
HGNC Alias namedolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase
HGNC Previous nameasparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)
 asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
LocusID (NCBI) 29929
Atlas_Id 54118
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 63367627 and ends at 63438552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG6 (1p31.3) / BMPR1B (4q22.3)ALG6 (1p31.3) / GNAS (20q13.32)ALG6 (1p31.3) / SMURF1 (7q22.1)
BMPR1B (4q22.3) / ALG6 (1p31.3)C1orf123 (1p32.3) / ALG6 (1p31.3)C1orf123 1p32.3 / ALG6 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALG6   23157
Cards
Entrez_Gene (NCBI)ALG6    ALG6 alpha-1,3-glucosyltransferase
AliasesCDG1C
GeneCards (Weizmann)ALG6
Ensembl hg19 (Hinxton)ENSG00000088035 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088035 [Gene_View]  ENSG00000088035 [Sequence]  chr1:63367627-63438552 [Contig_View]  ALG6 [Vega]
ICGC DataPortalENSG00000088035
TCGA cBioPortalALG6
AceView (NCBI)ALG6
Genatlas (Paris)ALG6
SOURCE (Princeton)ALG6
Genetics Home Reference (NIH)ALG6
Genomic and cartography
GoldenPath hg38 (UCSC)ALG6  -     chr1:63367627-63438552 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALG6  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathALG6 - 1p31.3 [CytoView hg19]  ALG6 - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000088035
genome Data Viewer NCBIALG6 [Mapview hg19]  
OMIM603147   604566   
Gene and transcription
Genbank (Entrez)AF063604 AF102851 AI479334 AK022700 AK295286
RefSeq transcript (Entrez)NM_013339
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALG6
Alternative Splicing GalleryENSG00000088035
Gene ExpressionALG6 [ NCBI-GEO ]   ALG6 [ EBI - ARRAY_EXPRESS ]   ALG6 [ SEEK ]   ALG6 [ MEM ]
Gene Expression Viewer (FireBrowse)ALG6 [ Firebrowse - Broad ]
GenevisibleExpression of ALG6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29929
GTEX Portal (Tissue expression)ALG6
Human Protein AtlasENSG00000088035-ALG6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y672   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y672  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y672
Splice isoforms : SwissVarQ9Y672
Catalytic activity : Enzyme2.4.1.267 [ Enzyme-Expasy ]   2.4.1.2672.4.1.267 [ IntEnz-EBI ]   2.4.1.267 [ BRENDA ]   2.4.1.267 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y672
Domains : Interpro (EBI)ALG6    Glyco_trans_ALG6/ALG8   
Domain families : Pfam (Sanger)Alg6_Alg8 (PF03155)   
Domain families : Pfam (NCBI)pfam03155   
Conserved Domain (NCBI)ALG6
Blocks (Seattle)ALG6
SuperfamilyQ9Y672
Human Protein Atlas [tissue]ENSG00000088035-ALG6 [tissue]
Peptide AtlasQ9Y672
HPRD05194
IPIIPI00797222   IPI00910880   IPI00300971   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y672
IntAct (EBI)Q9Y672
BioGRIDALG6
STRING (EMBL)ALG6
ZODIACALG6
Ontologies - Pathways
QuickGOQ9Y672
Ontology : AmiGOdolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  membrane  integral component of membrane  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  glucosyltransferase activity  
Ontology : EGO-EBIdolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  membrane  integral component of membrane  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  glucosyltransferase activity  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkALG6
Atlas of Cancer Signalling NetworkALG6
Wikipedia pathwaysALG6
Orthology - Evolution
OrthoDB29929
GeneTree (enSembl)ENSG00000088035
Phylogenetic Trees/Animal Genes : TreeFamALG6
HOGENOMQ9Y672
Homologs : HomoloGeneALG6
Homology/Alignments : Family Browser (UCSC)ALG6
Gene fusions - Rearrangements
Fusion : MitelmanALG6/BMPR1B [1p31.3/4q22.3]  
Fusion : MitelmanBMPR1B/ALG6 [4q22.3/1p31.3]  
Fusion : MitelmanC1orf123/ALG6 [1p32.3/1p31.3]  
Fusion PortalC1orf123 1p32.3 ALG6 1p31.3 BRCA
Fusion : QuiverALG6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALG6 [hg38]
dbVarALG6
ClinVarALG6
MonarchALG6
1000_GenomesALG6 
Exome Variant ServerALG6
GNOMAD BrowserENSG00000088035
Varsome BrowserALG6
Genomic Variants (DGV)ALG6 [DGVbeta]
DECIPHERALG6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALG6 
Mutations
ICGC Data PortalALG6 
TCGA Data PortalALG6 
Broad Tumor PortalALG6
OASIS PortalALG6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALG6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALG6
Mutations and Diseases : HGMDALG6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ALG6
DgiDB (Drug Gene Interaction Database)ALG6
DoCM (Curated mutations)ALG6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALG6 (select a term)
intoGenALG6
Cancer3DALG6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603147    604566   
Orphanet11346   
DisGeNETALG6
MedgenALG6
Genetic Testing Registry ALG6
NextProtQ9Y672 [Medical]
GENETestsALG6
Target ValidationALG6
Huge Navigator ALG6 [HugePedia]
ClinGenALG6
Clinical trials, drugs, therapy
MyCancerGenomeALG6
Protein Interactions : CTD
Pharm GKB GenePA134925619
PharosQ9Y672
Clinical trialALG6
Miscellaneous
canSAR (ICR)ALG6 (select the gene name)
HarmonizomeALG6
DataMed IndexALG6
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALG6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:10:38 CET 2021
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