Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ALG8 (ALG8, alpha-1,3-glucosyltransferase)

Identity

Alias_namesasparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
Alias_symbol (synonym)MGC2840
Other aliasCDG1H
HGNC (Hugo) ALG8
LocusID (NCBI) 79053
Atlas_Id 60255
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78100942 and ends at 78139653 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG8 (11q14.1) / A2M (12p13.31)ALG8 (11q14.1) / FGF19 (11q13.3)ALG8 (11q14.1) / NARS2 (11q14.1)
ALG8 NARS2ALG8 FGF19

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALG8   23161
Cards
Entrez_Gene (NCBI)ALG8  79053  ALG8, alpha-1,3-glucosyltransferase
AliasesCDG1H
GeneCards (Weizmann)ALG8
Ensembl hg19 (Hinxton)ENSG00000159063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159063 [Gene_View]  ENSG00000159063 [Sequence]  chr11:78100942-78139653 [Contig_View]  ALG8 [Vega]
ICGC DataPortalENSG00000159063
TCGA cBioPortalALG8
AceView (NCBI)ALG8
Genatlas (Paris)ALG8
WikiGenes79053
SOURCE (Princeton)ALG8
Genetics Home Reference (NIH)ALG8
Genomic and cartography
GoldenPath hg38 (UCSC)ALG8  -     chr11:78100942-78139653 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALG8  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathALG8 - 11q14.1 [CytoView hg19]  ALG8 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000159063
Mapping of homologs : NCBIALG8 [Mapview hg19]  ALG8 [Mapview hg38]
OMIM608103   608104   
Gene and transcription
Genbank (Entrez)AA375954 AJ224875 AK075184 AK075194 AK098614
RefSeq transcript (Entrez)NM_001007027 NM_001007028 NM_024079
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALG8
Cluster EST : UnigeneHs.503368 [ NCBI ]
CGAP (NCI)Hs.503368
Alternative Splicing GalleryENSG00000159063
Gene ExpressionALG8 [ NCBI-GEO ]   ALG8 [ EBI - ARRAY_EXPRESS ]   ALG8 [ SEEK ]   ALG8 [ MEM ]
Gene Expression Viewer (FireBrowse)ALG8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79053
GTEX Portal (Tissue expression)ALG8
Human Protein AtlasENSG00000159063-ALG8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVK2
Splice isoforms : SwissVarQ9BVK2
Catalytic activity : Enzyme2.4.1.265 [ Enzyme-Expasy ]   2.4.1.2652.4.1.265 [ IntEnz-EBI ]   2.4.1.265 [ BRENDA ]   2.4.1.265 [ KEGG ]   
PhosPhoSitePlusQ9BVK2
Domains : Interpro (EBI)Glyco_trans_ALG6/ALG8   
Domain families : Pfam (Sanger)Alg6_Alg8 (PF03155)   
Domain families : Pfam (NCBI)pfam03155   
Conserved Domain (NCBI)ALG8
DMDM Disease mutations79053
Blocks (Seattle)ALG8
SuperfamilyQ9BVK2
Human Protein Atlas [tissue]ENSG00000159063-ALG8 [tissue]
Peptide AtlasQ9BVK2
HPRD10480
IPIIPI00032370   IPI00979167   IPI00550318   IPI00985365   IPI00981741   IPI00983501   IPI00983749   IPI00983286   IPI00981402   IPI00982814   IPI00984111   IPI00984469   IPI00985194   IPI00976992   IPI00982605   IPI00979050   IPI00984812   
Protein Interaction databases
DIP (DOE-UCLA)Q9BVK2
IntAct (EBI)Q9BVK2
FunCoupENSG00000159063
BioGRIDALG8
STRING (EMBL)ALG8
ZODIACALG8
Ontologies - Pathways
QuickGOQ9BVK2
Ontology : AmiGOalpha-1,3-mannosyltransferase activity  dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  integral component of membrane  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  mannosylation  
Ontology : EGO-EBIalpha-1,3-mannosyltransferase activity  dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  integral component of membrane  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  mannosylation  
Pathways : KEGGGlycan structures - biosynthesis 1    N-Glycan biosynthesis   
NDEx NetworkALG8
Atlas of Cancer Signalling NetworkALG8
Wikipedia pathwaysALG8
Orthology - Evolution
OrthoDB79053
GeneTree (enSembl)ENSG00000159063
Phylogenetic Trees/Animal Genes : TreeFamALG8
HOGENOMQ9BVK2
Homologs : HomoloGeneALG8
Homology/Alignments : Family Browser (UCSC)ALG8
Gene fusions - Rearrangements
Fusion PortalALG8 NARS2
Fusion PortalALG8 FGF19
Fusion : QuiverALG8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALG8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALG8
dbVarALG8
ClinVarALG8
1000_GenomesALG8 
Exome Variant ServerALG8
ExAC (Exome Aggregation Consortium)ENSG00000159063
GNOMAD BrowserENSG00000159063
Varsome BrowserALG8
Genetic variants : HAPMAP79053
Genomic Variants (DGV)ALG8 [DGVbeta]
DECIPHERALG8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALG8 
Mutations
ICGC Data PortalALG8 
TCGA Data PortalALG8 
Broad Tumor PortalALG8
OASIS PortalALG8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALG8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALG8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ALG8
DgiDB (Drug Gene Interaction Database)ALG8
DoCM (Curated mutations)ALG8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALG8 (select a term)
intoGenALG8
Cancer3DALG8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608103    608104   
Orphanet11351   
DisGeNETALG8
MedgenALG8
Genetic Testing Registry ALG8
NextProtQ9BVK2 [Medical]
TSGene79053
GENETestsALG8
Target ValidationALG8
Huge Navigator ALG8 [HugePedia]
snp3D : Map Gene to Disease79053
BioCentury BCIQALG8
ClinGenALG8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79053
Chemical/Pharm GKB GenePA134942124
Clinical trialALG8
Miscellaneous
canSAR (ICR)ALG8 (select the gene name)
DataMed IndexALG8
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALG8
EVEXALG8
GoPubMedALG8
iHOPALG8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 7 17:10:32 CEST 2019
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