Alias (NCBI) | CDG1H |
| PCLD3 |
HGNC (Hugo) |
ALG8 |
HGNC Alias symb | MGC2840 |
HGNC Alias name | dolichyl-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase |
HGNC Previous name | asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase) |
| asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) |
LocusID (NCBI) |
79053 |
Atlas_Id |
60255 |
Location |
11q14.1 [Link to chromosome band 11q14] |
Location_base_pair |
Starts at 78100942 and ends at 78139653 bp from pter ( according to hg38-Dec_2013) |
| Nomenclature |
HGNC (Hugo) | ALG8 23161 |
| Cards |
Entrez_Gene (NCBI) | ALG8 ALG8 alpha-1,3-glucosyltransferase |
Aliases | CDG1H; PCLD3 |
GeneCards (Weizmann) | ALG8 |
Ensembl hg19 (Hinxton) | ENSG00000159063 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000159063 [Gene_View]  ENSG00000159063 [Sequence] chr11:78100942-78139653 [Contig_View] ALG8 [Vega] |
ICGC DataPortal | ENSG00000159063 |
TCGA cBioPortal | ALG8 |
AceView (NCBI) | ALG8 |
Genatlas (Paris) | ALG8 |
SOURCE (Princeton) | ALG8 |
Genetics Home Reference (NIH) | ALG8 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | ALG8 - chr11:78100942-78139653 - 11q14.1 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | ALG8 - 11q14.1 [Description] (hg19-Feb_2009) |
GoldenPath | ALG8 - 11q14.1 [CytoView hg19] ALG8 - 11q14.1 [CytoView hg38] |
ImmunoBase | ENSG00000159063 |
genome Data Viewer NCBI | ALG8 [Mapview hg19] |
OMIM | 608103 608104 617874 |
| Gene and transcription |
Genbank (Entrez) | AA375954 AJ224875 AK075184 AK075194 AK098614 |
RefSeq transcript (Entrez) | NM_001007027 NM_001007028 NM_024079 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | ALG8 |
Alternative Splicing Gallery | ENSG00000159063 |
Gene Expression | ALG8 [ NCBI-GEO ] ALG8 [ EBI - ARRAY_EXPRESS ]
ALG8 [ SEEK ] ALG8 [ MEM ] |
Gene Expression Viewer (FireBrowse) | ALG8 [ Firebrowse - Broad ] |
Genevisible | Expression of ALG8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 79053 |
GTEX Portal (Tissue expression) | ALG8 |
Human Protein Atlas | ENSG00000159063-ALG8 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q9BVK2 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q9BVK2 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q9BVK2 |
Splice isoforms : SwissVar | Q9BVK2 |
PhosPhoSitePlus | Q9BVK2 |
Domains : Interpro (EBI) | ALG8 Glyco_trans_ALG6/ALG8 |
Domain families : Pfam (Sanger) | Alg6_Alg8 (PF03155) |
Domain families : Pfam (NCBI) | pfam03155 |
Conserved Domain (NCBI) | ALG8 |
Blocks (Seattle) | ALG8 |
Superfamily | Q9BVK2 |
Human Protein Atlas [tissue] | ENSG00000159063-ALG8 [tissue] |
Peptide Atlas | Q9BVK2 |
HPRD | 10480 |
IPI | IPI00032370 IPI00979167 IPI00550318 IPI00985365 IPI00981741 IPI00983501 IPI00983749 IPI00983286 IPI00981402 IPI00982814 IPI00984111 IPI00984469 IPI00985194 IPI00976992 IPI00982605 IPI00979050 IPI00984812 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q9BVK2 |
IntAct (EBI) | Q9BVK2 |
BioGRID | ALG8 |
STRING (EMBL) | ALG8 |
ZODIAC | ALG8 |
| Ontologies - Pathways |
QuickGO | Q9BVK2 |
Ontology : AmiGO | alpha-1,3-mannosyltransferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity protein binding endoplasmic reticulum membrane endoplasmic reticulum membrane protein N-linked glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process oligosaccharide-lipid intermediate biosynthetic process integral component of membrane protein N-linked glycosylation via asparagine dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity mannosylation |
Ontology : EGO-EBI | alpha-1,3-mannosyltransferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity protein binding endoplasmic reticulum membrane endoplasmic reticulum membrane protein N-linked glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process oligosaccharide-lipid intermediate biosynthetic process integral component of membrane protein N-linked glycosylation via asparagine dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity mannosylation |
Pathways : KEGG | Glycan structures - biosynthesis 1 N-Glycan biosynthesis |
NDEx Network | ALG8 |
Atlas of Cancer Signalling Network | ALG8 |
Wikipedia pathways | ALG8 |
| Orthology - Evolution |
OrthoDB | 79053 |
GeneTree (enSembl) | ENSG00000159063 |
Phylogenetic Trees/Animal Genes : TreeFam | ALG8 |
HOGENOM | Q9BVK2 |
Homologs : HomoloGene | ALG8 |
Homology/Alignments : Family Browser (UCSC) | ALG8 |
| Gene fusions - Rearrangements |
Fusion Portal | ALG8 NARS2 |
Fusion Portal | ALG8 FGF19 |
Fusion : Quiver | ALG8 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | ALG8 [hg38] |
dbVar | ALG8 |
ClinVar | ALG8 |
Monarch | ALG8 |
1000_Genomes | ALG8 |
Exome Variant Server | ALG8 |
GNOMAD Browser | ENSG00000159063 |
Varsome Browser | ALG8 |
Genomic Variants (DGV) | ALG8 [DGVbeta] |
DECIPHER | ALG8 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | ALG8 |
| Mutations |
ICGC Data Portal | ALG8 |
TCGA Data Portal | ALG8 |
Broad Tumor Portal | ALG8 |
OASIS Portal | ALG8 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | ALG8 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | ALG8 |
Mutations and Diseases : HGMD | ALG8 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | Mendelian genes |
LOVD (Leiden Open Variation Database) | MSeqDR-LSDB Mitochondrial Disease Locus Specific Database |
BioMuta | search ALG8 |
DgiDB (Drug Gene Interaction Database) | ALG8 |
DoCM (Curated mutations) | ALG8 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | ALG8 (select a term) |
intoGen | ALG8 |
Cancer3D | ALG8(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 608103 608104 617874 |
Orphanet | 11351 |
DisGeNET | ALG8 |
Medgen | ALG8 |
Genetic Testing Registry | ALG8
|
NextProt | Q9BVK2 [Medical] |
GENETests | ALG8 |
Target Validation | ALG8 |
Huge Navigator |
ALG8 [HugePedia] |
ClinGen | ALG8 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | ALG8 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA134942124 |
Clinical trial | ALG8 |
| Miscellaneous |
---|
canSAR (ICR) | ALG8 (select the gene name) |
Harmonizome | ALG8 |
DataMed Index | ALG8 |
| Probes |
---|
| Litterature |
---|
PubMed | 29 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | ALG8 |
EVEX | ALG8 |
GoPubMed | ALG8 |