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ALG8 (ALG8 alpha-1,3-glucosyltransferase)

Identity

Alias (NCBI)CDG1H
PCLD3
HGNC (Hugo) ALG8
HGNC Alias symbMGC2840
HGNC Alias namedolichyl-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase
HGNC Previous nameasparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
 asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
LocusID (NCBI) 79053
Atlas_Id 60255
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78100946 and ends at 78139626 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG8 (11q14.1)::A2M (12p13.31)ALG8 (11q14.1)::FGF19 (11q13.3)ALG8 (11q14.1)::NARS2 (11q14.1)
ALG8 NARS2ALG8 FGF19

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)ALG8   23161
Cards
Entrez_Gene (NCBI)ALG8    ALG8 alpha-1,3-glucosyltransferase
AliasesCDG1H; PCLD3
GeneCards (Weizmann)ALG8
Ensembl hg19 (Hinxton)ENSG00000159063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159063 [Gene_View]  ENSG00000159063 [Sequence]  chr11:78100946-78139626 [Contig_View]  ALG8 [Vega]
ICGC DataPortalENSG00000159063
TCGA cBioPortalALG8
AceView (NCBI)ALG8
Genatlas (Paris)ALG8
SOURCE (Princeton)ALG8
Genetics Home Reference (NIH)ALG8
Genomic and cartography
GoldenPath hg38 (UCSC)ALG8  -     chr11:78100946-78139626 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALG8  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathALG8 - 11q14.1 [CytoView hg19]  ALG8 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000159063
Genome Data Viewer NCBIALG8 [Mapview hg19]  
OMIM608103   608104   617874   
Gene and transcription
Genbank (Entrez)AA375954 AJ224875 AK075184 AK075194 AK098614
RefSeq transcript (Entrez)NM_001007027 NM_001007028 NM_024079
Consensus coding sequences : CCDS (NCBI)ALG8
Gene ExpressionALG8 [ NCBI-GEO ]   ALG8 [ EBI - ARRAY_EXPRESS ]   ALG8 [ SEEK ]   ALG8 [ MEM ]
Gene Expression Viewer (FireBrowse)ALG8 [ Firebrowse - Broad ]
GenevisibleExpression of ALG8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79053
GTEX Portal (Tissue expression)ALG8
Human Protein AtlasENSG00000159063-ALG8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVK2
PhosPhoSitePlusQ9BVK2
Domains : Interpro (EBI)ALG8    Glyco_trans_ALG6/ALG8   
Domain families : Pfam (Sanger)Alg6_Alg8 (PF03155)   
Domain families : Pfam (NCBI)pfam03155   
Conserved Domain (NCBI)ALG8
SuperfamilyQ9BVK2
AlphaFold pdb e-kbQ9BVK2   
Human Protein Atlas [tissue]ENSG00000159063-ALG8 [tissue]
HPRD10480
Protein Interaction databases
DIP (DOE-UCLA)Q9BVK2
IntAct (EBI)Q9BVK2
BioGRIDALG8
STRING (EMBL)ALG8
ZODIACALG8
Ontologies - Pathways
QuickGOQ9BVK2
Ontology : AmiGOalpha-1,3-mannosyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  integral component of membrane  protein N-linked glycosylation via asparagine  dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  mannosylation  
Ontology : EGO-EBIalpha-1,3-mannosyltransferase activity  protein binding  endoplasmic reticulum membrane  endoplasmic reticulum membrane  protein N-linked glycosylation  protein N-linked glycosylation  dolichol-linked oligosaccharide biosynthetic process  oligosaccharide-lipid intermediate biosynthetic process  integral component of membrane  protein N-linked glycosylation via asparagine  dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity  mannosylation  
Pathways : KEGGGlycan structures - biosynthesis 1    N-Glycan biosynthesis   
NDEx NetworkALG8
Atlas of Cancer Signalling NetworkALG8
Wikipedia pathwaysALG8
Orthology - Evolution
OrthoDB79053
GeneTree (enSembl)ENSG00000159063
Phylogenetic Trees/Animal Genes : TreeFamALG8
Homologs : HomoloGeneALG8
Homology/Alignments : Family Browser (UCSC)ALG8
Gene fusions - Rearrangements
Fusion : QuiverALG8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALG8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALG8
dbVarALG8
ClinVarALG8
MonarchALG8
1000_GenomesALG8 
Exome Variant ServerALG8
GNOMAD BrowserENSG00000159063
Varsome BrowserALG8
ACMGALG8 variants
VarityQ9BVK2
Genomic Variants (DGV)ALG8 [DGVbeta]
DECIPHERALG8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALG8 
Mutations
ICGC Data PortalALG8 
TCGA Data PortalALG8 
Broad Tumor PortalALG8
OASIS PortalALG8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALG8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALG8
Mutations and Diseases : HGMDALG8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaALG8
DgiDB (Drug Gene Interaction Database)ALG8
DoCM (Curated mutations)ALG8
CIViC (Clinical Interpretations of Variants in Cancer)ALG8
Cancer3DALG8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608103    608104    617874   
Orphanet11351   
DisGeNETALG8
MedgenALG8
Genetic Testing Registry ALG8
NextProtQ9BVK2 [Medical]
GENETestsALG8
Target ValidationALG8
Huge Navigator ALG8 [HugePedia]
ClinGenALG8
Clinical trials, drugs, therapy
MyCancerGenomeALG8
Protein Interactions : CTDALG8
Pharm GKB GenePA134942124
PharosQ9BVK2
Clinical trialALG8
Miscellaneous
canSAR (ICR)ALG8
HarmonizomeALG8
ARCHS4ALG8
DataMed IndexALG8
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALG8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:44:23 CET 2022
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