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ALKAL2 (ALK and LTK ligand 2)

Identity

Other aliasAUGA
FAM150B
PRO1097
RGPG542
HGNC (Hugo) ALKAL2
LocusID (NCBI) 285016
Atlas_Id 56753
Location 2p25.3  [Link to chromosome band 2p25]
Location_base_pair Starts at 279561 and ends at 288308 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALKAL2   27683
Cards
Entrez_Gene (NCBI)ALKAL2  285016  ALK and LTK ligand 2
AliasesAUGA; FAM150B; PRO1097; RGPG542
GeneCards (Weizmann)ALKAL2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:279561-288308 [Contig_View]  ALKAL2 [Vega]
TCGA cBioPortalALKAL2
AceView (NCBI)ALKAL2
Genatlas (Paris)ALKAL2
WikiGenes285016
SOURCE (Princeton)ALKAL2
Genetics Home Reference (NIH)ALKAL2
Genomic and cartography
GoldenPath hg38 (UCSC)ALKAL2  -     chr2:279561-288308 -  2p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALKAL2  -     2p25.3   [Description]    (hg19-Feb_2009)
EnsemblALKAL2 - 2p25.3 [CytoView hg19]  ALKAL2 - 2p25.3 [CytoView hg38]
Mapping of homologs : NCBIALKAL2 [Mapview hg19]  ALKAL2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI300876 AI769402 AY358517 BC033490 BC141485
RefSeq transcript (Entrez)NM_001002919
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALKAL2
Cluster EST : UnigeneHs.355207 [ NCBI ]
CGAP (NCI)Hs.355207
Gene ExpressionALKAL2 [ NCBI-GEO ]   ALKAL2 [ EBI - ARRAY_EXPRESS ]   ALKAL2 [ SEEK ]   ALKAL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKAL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285016
GTEX Portal (Tissue expression)ALKAL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UX46   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UX46  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UX46
Splice isoforms : SwissVarQ6UX46
PhosPhoSitePlusQ6UX46
Domains : Interpro (EBI)FAM150   
Domain families : Pfam (Sanger)FAM150 (PF15129)   
Domain families : Pfam (NCBI)pfam15129   
Conserved Domain (NCBI)ALKAL2
DMDM Disease mutations285016
Blocks (Seattle)ALKAL2
SuperfamilyQ6UX46
Peptide AtlasQ6UX46
IPIIPI00929374   IPI00939453   IPI00894512   IPI00745749   IPI00893817   
Protein Interaction databases
DIP (DOE-UCLA)Q6UX46
IntAct (EBI)Q6UX46
BioGRIDALKAL2
STRING (EMBL)ALKAL2
ZODIACALKAL2
Ontologies - Pathways
QuickGOQ6UX46
Ontology : AmiGOprotein binding  extracellular region  positive regulation of neuron projection development  receptor signaling protein tyrosine kinase activator activity  receptor tyrosine kinase binding  positive regulation of protein tyrosine kinase activity  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK5 cascade  
Ontology : EGO-EBIprotein binding  extracellular region  positive regulation of neuron projection development  receptor signaling protein tyrosine kinase activator activity  receptor tyrosine kinase binding  positive regulation of protein tyrosine kinase activity  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK5 cascade  
NDEx NetworkALKAL2
Atlas of Cancer Signalling NetworkALKAL2
Wikipedia pathwaysALKAL2
Orthology - Evolution
OrthoDB285016
Phylogenetic Trees/Animal Genes : TreeFamALKAL2
HOVERGENQ6UX46
HOGENOMQ6UX46
Homologs : HomoloGeneALKAL2
Homology/Alignments : Family Browser (UCSC)ALKAL2
Gene fusions - Rearrangements
Tumor Fusion PortalALKAL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKAL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKAL2
dbVarALKAL2
ClinVarALKAL2
1000_GenomesALKAL2 
Exome Variant ServerALKAL2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP285016
Genomic Variants (DGV)ALKAL2 [DGVbeta]
DECIPHERALKAL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALKAL2 
Mutations
ICGC Data PortalALKAL2 
TCGA Data PortalALKAL2 
Broad Tumor PortalALKAL2
OASIS PortalALKAL2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDALKAL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKAL2
DgiDB (Drug Gene Interaction Database)ALKAL2
DoCM (Curated mutations)ALKAL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKAL2 (select a term)
intoGenALKAL2
Cancer3DALKAL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETALKAL2
MedgenALKAL2
Genetic Testing Registry ALKAL2
NextProtQ6UX46 [Medical]
TSGene285016
GENETestsALKAL2
Target ValidationALKAL2
Huge Navigator ALKAL2 [HugePedia]
snp3D : Map Gene to Disease285016
BioCentury BCIQALKAL2
ClinGenALKAL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD285016
Chemical/Pharm GKB GenePA162386448
Clinical trialALKAL2
Miscellaneous
canSAR (ICR)ALKAL2 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALKAL2
EVEXALKAL2
GoPubMedALKAL2
iHOPALKAL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:45 CET 2017

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