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ALKBH2 (alkB homolog 2, alpha-ketoglutarate dependent dioxygenase)

Identity

Alias_namesalkB
Alias_symbol (synonym)MGC90512
ABH2
Other alias
HGNC (Hugo) ALKBH2
LocusID (NCBI) 121642
Atlas_Id 53082
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 109088188 and ends at 109093488 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALKBH2   32487
Cards
Entrez_Gene (NCBI)ALKBH2  121642  alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
AliasesABH2
GeneCards (Weizmann)ALKBH2
Ensembl hg19 (Hinxton)ENSG00000189046 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000189046 [Gene_View]  chr12:109088188-109093488 [Contig_View]  ALKBH2 [Vega]
ICGC DataPortalENSG00000189046
TCGA cBioPortalALKBH2
AceView (NCBI)ALKBH2
Genatlas (Paris)ALKBH2
WikiGenes121642
SOURCE (Princeton)ALKBH2
Genetics Home Reference (NIH)ALKBH2
Genomic and cartography
GoldenPath hg38 (UCSC)ALKBH2  -     chr12:109088188-109093488 -  12q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALKBH2  -     12q24.11   [Description]    (hg19-Feb_2009)
EnsemblALKBH2 - 12q24.11 [CytoView hg19]  ALKBH2 - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBIALKBH2 [Mapview hg19]  ALKBH2 [Mapview hg38]
OMIM610602   
Gene and transcription
Genbank (Entrez)AB277859 AI278638 AK309062 AY754389 BC070489
RefSeq transcript (Entrez)NM_001001655 NM_001145374 NM_001145375 NM_001205179 NM_001205180
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALKBH2
Cluster EST : UnigeneHs.374458 [ NCBI ]
CGAP (NCI)Hs.374458
Alternative Splicing GalleryENSG00000189046
Gene ExpressionALKBH2 [ NCBI-GEO ]   ALKBH2 [ EBI - ARRAY_EXPRESS ]   ALKBH2 [ SEEK ]   ALKBH2 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)121642
GTEX Portal (Tissue expression)ALKBH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6NS38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6NS38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6NS38
Splice isoforms : SwissVarQ6NS38
Catalytic activity : Enzyme1.14.11.33 [ Enzyme-Expasy ]   1.14.11.331.14.11.33 [ IntEnz-EBI ]   1.14.11.33 [ BRENDA ]   1.14.11.33 [ KEGG ]   
PhosPhoSitePlusQ6NS38
Domaine pattern : Prosite (Expaxy)FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)AlkB-like    Oxoglu/Fe-dep_dioxygenase   
Domain families : Pfam (Sanger)2OG-FeII_Oxy_2 (PF13532)   
Domain families : Pfam (NCBI)pfam13532   
Conserved Domain (NCBI)ALKBH2
DMDM Disease mutations121642
Blocks (Seattle)ALKBH2
PDB (SRS)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
PDB (PDBSum)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
PDB (IMB)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
PDB (RSDB)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
Structural Biology KnowledgeBase3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
SCOP (Structural Classification of Proteins)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
CATH (Classification of proteins structures)3BTX    3BTY    3BTZ    3BU0    3BUC    3H8O    3H8R    3H8X    3RZG    3RZH    3RZJ    3RZK    3RZL    3RZM    3S57    3S5A    4MG2    4MGT   
SuperfamilyQ6NS38
Human Protein AtlasENSG00000189046
Peptide AtlasQ6NS38
HPRD14712
IPIIPI00055405   IPI00845369   IPI01013336   IPI01013805   IPI01012584   
Protein Interaction databases
DIP (DOE-UCLA)Q6NS38
IntAct (EBI)Q6NS38
FunCoupENSG00000189046
BioGRIDALKBH2
STRING (EMBL)ALKBH2
ZODIACALKBH2
Ontologies - Pathways
QuickGOQ6NS38
Ontology : AmiGOnucleus  nucleoplasm  nucleoplasm  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  microtubule cytoskeleton  oxidative DNA demethylation  DNA-N1-methyladenine dioxygenase activity  cytosine C-5 DNA demethylase activity  cytosine C-5 DNA demethylase activity  oxidative demethylation  DNA demethylation  1-ethyladenine demethylase activity  
Ontology : EGO-EBInucleus  nucleoplasm  nucleoplasm  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  microtubule cytoskeleton  oxidative DNA demethylation  DNA-N1-methyladenine dioxygenase activity  cytosine C-5 DNA demethylase activity  cytosine C-5 DNA demethylase activity  oxidative demethylation  DNA demethylation  1-ethyladenine demethylase activity  
NDEx NetworkALKBH2
Atlas of Cancer Signalling NetworkALKBH2
Wikipedia pathwaysALKBH2
Orthology - Evolution
OrthoDB121642
GeneTree (enSembl)ENSG00000189046
Phylogenetic Trees/Animal Genes : TreeFamALKBH2
HOVERGENQ6NS38
HOGENOMQ6NS38
Homologs : HomoloGeneALKBH2
Homology/Alignments : Family Browser (UCSC)ALKBH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKBH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKBH2
dbVarALKBH2
ClinVarALKBH2
1000_GenomesALKBH2 
Exome Variant ServerALKBH2
ExAC (Exome Aggregation Consortium)ALKBH2 (select the gene name)
Genetic variants : HAPMAP121642
Genomic Variants (DGV)ALKBH2 [DGVbeta]
DECIPHERALKBH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALKBH2 
Mutations
ICGC Data PortalALKBH2 
TCGA Data PortalALKBH2 
Broad Tumor PortalALKBH2
OASIS PortalALKBH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALKBH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKBH2
DgiDB (Drug Gene Interaction Database)ALKBH2
DoCM (Curated mutations)ALKBH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH2 (select a term)
intoGenALKBH2
Cancer3DALKBH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610602   
Orphanet
MedgenALKBH2
Genetic Testing Registry ALKBH2
NextProtQ6NS38 [Medical]
TSGene121642
GENETestsALKBH2
Target ValidationALKBH2
Huge Navigator ALKBH2 [HugePedia]
snp3D : Map Gene to Disease121642
BioCentury BCIQALKBH2
ClinGenALKBH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD121642
Chemical/Pharm GKB GenePA143485292
Clinical trialALKBH2
Miscellaneous
canSAR (ICR)ALKBH2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALKBH2
EVEXALKBH2
GoPubMedALKBH2
iHOPALKBH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:57 CEST 2017

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