Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase)

Identity

Alias (NCBI)ABH3
DEPC-1
DEPC1
PCA1
hABH3
HGNC (Hugo) ALKBH3
HGNC Alias symbDEPC-1
HGNC Previous namealkB, alkylation repair homolog 3 (E. coli)
LocusID (NCBI) 221120
Atlas_Id 53106
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 43880831 and ends at 43920274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALKBH3 (11p11.2) / ACTN2 (1q43)ALKBH3 (11p11.2) / ANO3 (11p14.2)ALKBH3 (11p11.2) / TCIRG1 (11q13.2)
EXT2 (11p11.2) / ALKBH3 (11p11.2)PHF21A (11p11.2) / ALKBH3 (11p11.2)ALKBH3 11p11.2 / ANO3 11p14.2
EXT2 11p11.2 / ALKBH3 11p11.2PHF21A 11p11.2 / ALKBH3 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALKBH3   30141
Cards
Entrez_Gene (NCBI)ALKBH3    alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
AliasesABH3; DEPC-1; DEPC1; PCA1; 
hABH3
GeneCards (Weizmann)ALKBH3
Ensembl hg19 (Hinxton)ENSG00000166199 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166199 [Gene_View]  ENSG00000166199 [Sequence]  chr11:43880831-43920274 [Contig_View]  ALKBH3 [Vega]
ICGC DataPortalENSG00000166199
TCGA cBioPortalALKBH3
AceView (NCBI)ALKBH3
Genatlas (Paris)ALKBH3
SOURCE (Princeton)ALKBH3
Genetics Home Reference (NIH)ALKBH3
Genomic and cartography
GoldenPath hg38 (UCSC)ALKBH3  -     chr11:43880831-43920274 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALKBH3  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathALKBH3 - 11p11.2 [CytoView hg19]  ALKBH3 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000166199
genome Data Viewer NCBIALKBH3 [Mapview hg19]  
OMIM610603   
Gene and transcription
Genbank (Entrez)AB042029 AK125602 AK315266 BC015155 BC067257
RefSeq transcript (Entrez)NM_139178
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALKBH3
Alternative Splicing GalleryENSG00000166199
Gene ExpressionALKBH3 [ NCBI-GEO ]   ALKBH3 [ EBI - ARRAY_EXPRESS ]   ALKBH3 [ SEEK ]   ALKBH3 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH3 [ Firebrowse - Broad ]
GenevisibleExpression of ALKBH3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221120
GTEX Portal (Tissue expression)ALKBH3
Human Protein AtlasENSG00000166199-ALKBH3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96Q83   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96Q83  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96Q83
Splice isoforms : SwissVarQ96Q83
PhosPhoSitePlusQ96Q83
Domaine pattern : Prosite (Expaxy)FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)AlkB-like    AlkB-like_sf    ALKBH3    Oxoglu/Fe-dep_dioxygenase   
Domain families : Pfam (Sanger)2OG-FeII_Oxy_2 (PF13532)   
Domain families : Pfam (NCBI)pfam13532   
Conserved Domain (NCBI)ALKBH3
Blocks (Seattle)ALKBH3
PDB (RSDB)2IUW   
PDB Europe2IUW   
PDB (PDBSum)2IUW   
PDB (IMB)2IUW   
Structural Biology KnowledgeBase2IUW   
SCOP (Structural Classification of Proteins)2IUW   
CATH (Classification of proteins structures)2IUW   
SuperfamilyQ96Q83
Human Protein Atlas [tissue]ENSG00000166199-ALKBH3 [tissue]
Peptide AtlasQ96Q83
HPRD16793
IPIIPI00076597   IPI00433171   IPI00978658   IPI00977998   IPI00978103   IPI00977892   IPI00980052   
Protein Interaction databases
DIP (DOE-UCLA)Q96Q83
IntAct (EBI)Q96Q83
BioGRIDALKBH3
STRING (EMBL)ALKBH3
ZODIACALKBH3
Ontologies - Pathways
QuickGOQ96Q83
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  cytosol  DNA repair  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  cell population proliferation  L-ascorbic acid binding  oxidative single-stranded DNA demethylation  oxidative single-stranded DNA demethylation  oxidative single-stranded RNA demethylation  DNA-N1-methyladenine dioxygenase activity  DNA-N1-methyladenine dioxygenase activity  RNA N1-methyladenosine dioxygenase activity  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  cytosol  DNA repair  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  cell population proliferation  L-ascorbic acid binding  oxidative single-stranded DNA demethylation  oxidative single-stranded DNA demethylation  oxidative single-stranded RNA demethylation  DNA-N1-methyladenine dioxygenase activity  DNA-N1-methyladenine dioxygenase activity  RNA N1-methyladenosine dioxygenase activity  
NDEx NetworkALKBH3
Atlas of Cancer Signalling NetworkALKBH3
Wikipedia pathwaysALKBH3
Orthology - Evolution
OrthoDB221120
GeneTree (enSembl)ENSG00000166199
Phylogenetic Trees/Animal Genes : TreeFamALKBH3
HOGENOMQ96Q83
Homologs : HomoloGeneALKBH3
Homology/Alignments : Family Browser (UCSC)ALKBH3
Gene fusions - Rearrangements
Fusion : MitelmanALKBH3/ANO3 [11p11.2/11p14.2]  
Fusion : MitelmanEXT2/ALKBH3 [11p11.2/11p11.2]  
Fusion : MitelmanPHF21A/ALKBH3 [11p11.2/11p11.2]  
Fusion PortalALKBH3 11p11.2 ANO3 11p14.2 LUSC
Fusion PortalEXT2 11p11.2 ALKBH3 11p11.2 SKCM
Fusion PortalPHF21A 11p11.2 ALKBH3 11p11.2 LUAD
Fusion : QuiverALKBH3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKBH3 [hg38]
dbVarALKBH3
ClinVarALKBH3
MonarchALKBH3
1000_GenomesALKBH3 
Exome Variant ServerALKBH3
GNOMAD BrowserENSG00000166199
Varsome BrowserALKBH3
Genomic Variants (DGV)ALKBH3 [DGVbeta]
DECIPHERALKBH3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALKBH3 
Mutations
ICGC Data PortalALKBH3 
TCGA Data PortalALKBH3 
Broad Tumor PortalALKBH3
OASIS PortalALKBH3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALKBH3
Mutations and Diseases : HGMDALKBH3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKBH3
DgiDB (Drug Gene Interaction Database)ALKBH3
DoCM (Curated mutations)ALKBH3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH3 (select a term)
intoGenALKBH3
Cancer3DALKBH3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610603   
Orphanet
DisGeNETALKBH3
MedgenALKBH3
Genetic Testing Registry ALKBH3
NextProtQ96Q83 [Medical]
GENETestsALKBH3
Target ValidationALKBH3
Huge Navigator ALKBH3 [HugePedia]
ClinGenALKBH3
Clinical trials, drugs, therapy
MyCancerGenomeALKBH3
Protein Interactions : CTD
Pharm GKB GenePA143485293
PharosQ96Q83
Clinical trialALKBH3
Miscellaneous
canSAR (ICR)ALKBH3 (select the gene name)
HarmonizomeALKBH3
DataMed IndexALKBH3
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALKBH3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:10:39 CET 2021
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