ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase)

2012-12-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
ABH3,DEPC-1,DEPC1,PCA1,hABH3
FUSION GENES

Other Information

Locus ID:

NCBI: 221120
MIM: 610603
HGNC: 30141
Ensembl: ENSG00000166199

Variants:

dbSNP: 221120
ClinVar: 221120
TCGA: ENSG00000166199
COSMIC: ALKBH3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166199ENST00000302708Q96Q83
ENSG00000166199ENST00000524742E9PRD0
ENSG00000166199ENST00000529366E9PSA5
ENSG00000166199ENST00000530803Q96Q83
ENSG00000166199ENST00000532129H0YDH4
ENSG00000166199ENST00000532962E9PN35
ENSG00000166199ENST00000534171E9PRJ2

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Damage ReversalREACTOMER-HSA-73942
Reversal of alkylation damage by DNA dioxygenasesREACTOMER-HSA-73943
ALKBH3 mediated reversal of alkylation damageREACTOMER-HSA-112126

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168584102006Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.64
220551842011DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.58
212859822011ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.28
228266052012PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.22
282055602017AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.20
209701192011Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.18
207145062010Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3.14
228505672012ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals.14
225155252012anti-tumor effect of AlkB homolog 3 knockdown in hormone- independent prostate cancer cells.13
205257952010Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.9

Citation

Dessen P

ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53106/alkbh3