| Nomenclature |
|---|
| HGNC (Hugo) | ALKBH8 25189 |
| Cards |
|---|
| Entrez_Gene (NCBI) | ALKBH8 91801 alkB homolog 8, tRNA methyltransferase |
| Aliases | ABH8; TRM9; TRMT9; TRMT9A |
| GeneCards (Weizmann) | ALKBH8 |
| Ensembl hg19 (Hinxton) | ENSG00000137760 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000137760 [Gene_View] ENSG00000137760 [Sequence] chr11:107502727-107565735 [Contig_View] ALKBH8 [Vega] |
| ICGC DataPortal | ENSG00000137760 |
| TCGA cBioPortal | ALKBH8 |
| AceView (NCBI) | ALKBH8 |
| Genatlas (Paris) | ALKBH8 |
| WikiGenes | 91801 |
| SOURCE (Princeton) | ALKBH8 |
| Genetics Home Reference (NIH) | ALKBH8 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | ALKBH8 - chr11:107502727-107565735 - 11q22.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | ALKBH8 - 11q22.3 [Description] (hg19-Feb_2009) |
| Ensembl | ALKBH8 - 11q22.3 [CytoView hg19] ALKBH8 - 11q22.3 [CytoView hg38] |
| Mapping of homologs : NCBI | ALKBH8 [Mapview hg19] ALKBH8 [Mapview hg38] |
| OMIM | 613306 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB218768 AF086489 AK095523 AK293603 AK298800 |
| RefSeq transcript (Entrez) | NM_001301010 NM_138775 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | ALKBH8 |
| Cluster EST : Unigene | Hs.503763 [ NCBI ] |
| CGAP (NCI) | Hs.503763 |
| Alternative Splicing Gallery | ENSG00000137760 |
| Gene Expression | ALKBH8 [ NCBI-GEO ] ALKBH8 [ EBI - ARRAY_EXPRESS ]
ALKBH8 [ SEEK ] ALKBH8 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | ALKBH8 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 91801 |
| GTEX Portal (Tissue expression) | ALKBH8 |
| Human Protein Atlas | ENSG00000137760-ALKBH8 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q96BT7 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q96BT7 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q96BT7 |
| Splice isoforms : SwissVar | Q96BT7 |
| Catalytic activity : Enzyme | 1.14.11.- [ Enzyme-Expasy ] 1.14.11.-1.14.11.- [ IntEnz-EBI ] 1.14.11.- [ BRENDA ] 1.14.11.- [ KEGG ] |
| PhosPhoSitePlus | Q96BT7 |
| Domaine pattern : Prosite (Expaxy) | FE2OG_OXY (PS51471) |
| Domains : Interpro (EBI) | AlkB-like AlkB_hom8_N ALKBH8 ALKBH8_RRM Methyltransf_11 Nucleotide-bd_a/b_plait_sf Oxoglu/Fe-dep_dioxygenase RBD_domain_sf SAM-dependent_MTases |
| Domain families : Pfam (Sanger) | 2OG-FeII_Oxy_2 (PF13532) DUF1891 (PF09004) Methyltransf_11 (PF08241) |
| Domain families : Pfam (NCBI) | pfam13532 pfam09004 pfam08241 |
| Conserved Domain (NCBI) | ALKBH8 |
| DMDM Disease mutations | 91801 |
| Blocks (Seattle) | ALKBH8 |
| PDB (SRS) | 2CQ2 3THP 3THT |
| PDB (PDBSum) | 2CQ2 3THP 3THT |
| PDB (IMB) | 2CQ2 3THP 3THT |
| PDB (RSDB) | 2CQ2 3THP 3THT |
| Structural Biology KnowledgeBase | 2CQ2 3THP 3THT |
| SCOP (Structural Classification of Proteins) | 2CQ2 3THP 3THT |
| CATH (Classification of proteins structures) | 2CQ2 3THP 3THT |
| Superfamily | Q96BT7 |
| Human Protein Atlas [tissue] | ENSG00000137760-ALKBH8 [tissue] |
| Peptide Atlas | Q96BT7 |
| HPRD | 14287 |
| IPI | IPI00154533 IPI00026191 IPI00873081 IPI00966763 IPI00973899 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q96BT7 |
| IntAct (EBI) | Q96BT7 |
| FunCoup | ENSG00000137760 |
| BioGRID | ALKBH8 |
| STRING (EMBL) | ALKBH8 |
| ZODIAC | ALKBH8 |
| Ontologies - Pathways |
|---|
| QuickGO | Q96BT7 |
| Ontology : AmiGO | tRNA binding tRNA binding tRNA wobble uridine modification tRNA wobble uridine modification iron ion binding protein binding nucleus nucleus nucleoplasm cytoplasm cytosol cellular response to DNA damage stimulus zinc ion binding tRNA (uracil) methyltransferase activity tRNA (uracil) methyltransferase activity nuclear body oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors tRNA methylation oxidation-reduction process |
| Ontology : EGO-EBI | tRNA binding tRNA binding tRNA wobble uridine modification tRNA wobble uridine modification iron ion binding protein binding nucleus nucleus nucleoplasm cytoplasm cytosol cellular response to DNA damage stimulus zinc ion binding tRNA (uracil) methyltransferase activity tRNA (uracil) methyltransferase activity nuclear body oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors tRNA methylation oxidation-reduction process |
| NDEx Network | ALKBH8 |
| Atlas of Cancer Signalling Network | ALKBH8 |
| Wikipedia pathways | ALKBH8 |
| Orthology - Evolution |
|---|
| OrthoDB | 91801 |
| GeneTree (enSembl) | ENSG00000137760 |
| Phylogenetic Trees/Animal Genes : TreeFam | ALKBH8 |
| HOVERGEN | Q96BT7 |
| HOGENOM | Q96BT7 |
| Homologs : HomoloGene | ALKBH8 |
| Homology/Alignments : Family Browser (UCSC) | ALKBH8 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | ALKBH8 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | ALKBH8 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | ALKBH8 |
| dbVar | ALKBH8 |
| ClinVar | ALKBH8 |
| 1000_Genomes | ALKBH8 |
| Exome Variant Server | ALKBH8 |
| ExAC (Exome Aggregation Consortium) | ENSG00000137760 |
| GNOMAD Browser | ENSG00000137760 |
| Varsome Browser | ALKBH8 |
| Genetic variants : HAPMAP | 91801 |
| Genomic Variants (DGV) | ALKBH8 [DGVbeta] |
| DECIPHER | ALKBH8 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | ALKBH8 |
| Mutations |
|---|
| ICGC Data Portal | ALKBH8 |
| TCGA Data Portal | ALKBH8 |
| Broad Tumor Portal | ALKBH8 |
| OASIS Portal | ALKBH8 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | ALKBH8 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | ALKBH8 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search ALKBH8 |
| DgiDB (Drug Gene Interaction Database) | ALKBH8 |
| DoCM (Curated mutations) | ALKBH8 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | ALKBH8 (select a term) |
| intoGen | ALKBH8 |
| Cancer3D | ALKBH8(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 613306 |
| Orphanet | |
| DisGeNET | ALKBH8 |
| Medgen | ALKBH8 |
| Genetic Testing Registry | ALKBH8
|
| NextProt | Q96BT7 [Medical] |
| TSGene | 91801 |
| GENETests | ALKBH8 |
| Target Validation | ALKBH8 |
| Huge Navigator |
ALKBH8 [HugePedia] |
| snp3D : Map Gene to Disease | 91801 |
| BioCentury BCIQ | ALKBH8 |
| ClinGen | ALKBH8 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 91801 |
| Chemical/Pharm GKB Gene | PA143485296 |
| Clinical trial | ALKBH8 |
| Miscellaneous |
|---|
| canSAR (ICR) | ALKBH8 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 16 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | ALKBH8 |
| EVEX | ALKBH8 |
| GoPubMed | ALKBH8 |
| iHOP | ALKBH8 |
