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ALKBH8 (alkB homolog 8, tRNA methyltransferase)

Identity

Alias_namesalkB
Alias_symbol (synonym)MGC10235
TRM9
TRMT9
Other aliasABH8
HGNC (Hugo) ALKBH8
LocusID (NCBI) 91801
Atlas_Id 43082
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 107502727 and ends at 107565735 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALKBH8 (11q22.3) / ALKBH8 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALKBH8   25189
Cards
Entrez_Gene (NCBI)ALKBH8  91801  alkB homolog 8, tRNA methyltransferase
AliasesABH8; TRM9; TRMT9
GeneCards (Weizmann)ALKBH8
Ensembl hg19 (Hinxton)ENSG00000137760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137760 [Gene_View]  chr11:107502727-107565735 [Contig_View]  ALKBH8 [Vega]
ICGC DataPortalENSG00000137760
TCGA cBioPortalALKBH8
AceView (NCBI)ALKBH8
Genatlas (Paris)ALKBH8
WikiGenes91801
SOURCE (Princeton)ALKBH8
Genetics Home Reference (NIH)ALKBH8
Genomic and cartography
GoldenPath hg38 (UCSC)ALKBH8  -     chr11:107502727-107565735 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALKBH8  -     11q22.3   [Description]    (hg19-Feb_2009)
EnsemblALKBH8 - 11q22.3 [CytoView hg19]  ALKBH8 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBIALKBH8 [Mapview hg19]  ALKBH8 [Mapview hg38]
OMIM613306   
Gene and transcription
Genbank (Entrez)AB218768 AF086489 AK095523 AK293603 AK298800
RefSeq transcript (Entrez)NM_001301010 NM_138775
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALKBH8
Cluster EST : UnigeneHs.503763 [ NCBI ]
CGAP (NCI)Hs.503763
Alternative Splicing GalleryENSG00000137760
Gene ExpressionALKBH8 [ NCBI-GEO ]   ALKBH8 [ EBI - ARRAY_EXPRESS ]   ALKBH8 [ SEEK ]   ALKBH8 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91801
GTEX Portal (Tissue expression)ALKBH8
Human Protein AtlasENSG00000137760-ALKBH8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BT7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BT7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BT7
Splice isoforms : SwissVarQ96BT7
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.-1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
PhosPhoSitePlusQ96BT7
Domaine pattern : Prosite (Expaxy)FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)AlkB-like    AlkB_hom8_N    ALKBH8    ALKBH8_RRM    Methyltransf_11    Nucleotide-bd_a/b_plait    Oxoglu/Fe-dep_dioxygenase    RRM_dom    SAM-dependent_MTases   
Domain families : Pfam (Sanger)2OG-FeII_Oxy_2 (PF13532)    DUF1891 (PF09004)    Methyltransf_11 (PF08241)   
Domain families : Pfam (NCBI)pfam13532    pfam09004    pfam08241   
Conserved Domain (NCBI)ALKBH8
DMDM Disease mutations91801
Blocks (Seattle)ALKBH8
PDB (SRS)2CQ2    3THP    3THT   
PDB (PDBSum)2CQ2    3THP    3THT   
PDB (IMB)2CQ2    3THP    3THT   
PDB (RSDB)2CQ2    3THP    3THT   
Structural Biology KnowledgeBase2CQ2    3THP    3THT   
SCOP (Structural Classification of Proteins)2CQ2    3THP    3THT   
CATH (Classification of proteins structures)2CQ2    3THP    3THT   
SuperfamilyQ96BT7
Human Protein Atlas [tissue]ENSG00000137760-ALKBH8 [tissue]
Peptide AtlasQ96BT7
HPRD14287
IPIIPI00154533   IPI00026191   IPI00873081   IPI00966763   IPI00973899   
Protein Interaction databases
DIP (DOE-UCLA)Q96BT7
IntAct (EBI)Q96BT7
FunCoupENSG00000137760
BioGRIDALKBH8
STRING (EMBL)ALKBH8
ZODIACALKBH8
Ontologies - Pathways
QuickGOQ96BT7
Ontology : AmiGOtRNA binding  tRNA wobble uridine modification  iron ion binding  protein binding  nucleus  nucleoplasm  cytosol  cellular response to DNA damage stimulus  ferrous iron binding  zinc ion binding  tRNA (uracil) methyltransferase activity  nuclear body  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  tRNA methylation  oxidation-reduction process  
Ontology : EGO-EBItRNA binding  tRNA wobble uridine modification  iron ion binding  protein binding  nucleus  nucleoplasm  cytosol  cellular response to DNA damage stimulus  ferrous iron binding  zinc ion binding  tRNA (uracil) methyltransferase activity  nuclear body  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  tRNA methylation  oxidation-reduction process  
NDEx NetworkALKBH8
Atlas of Cancer Signalling NetworkALKBH8
Wikipedia pathwaysALKBH8
Orthology - Evolution
OrthoDB91801
GeneTree (enSembl)ENSG00000137760
Phylogenetic Trees/Animal Genes : TreeFamALKBH8
HOVERGENQ96BT7
HOGENOMQ96BT7
Homologs : HomoloGeneALKBH8
Homology/Alignments : Family Browser (UCSC)ALKBH8
Gene fusions - Rearrangements
Tumor Fusion PortalALKBH8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKBH8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKBH8
dbVarALKBH8
ClinVarALKBH8
1000_GenomesALKBH8 
Exome Variant ServerALKBH8
ExAC (Exome Aggregation Consortium)ENSG00000137760
GNOMAD BrowserENSG00000137760
Genetic variants : HAPMAP91801
Genomic Variants (DGV)ALKBH8 [DGVbeta]
DECIPHERALKBH8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALKBH8 
Mutations
ICGC Data PortalALKBH8 
TCGA Data PortalALKBH8 
Broad Tumor PortalALKBH8
OASIS PortalALKBH8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALKBH8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKBH8
DgiDB (Drug Gene Interaction Database)ALKBH8
DoCM (Curated mutations)ALKBH8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH8 (select a term)
intoGenALKBH8
Cancer3DALKBH8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613306   
Orphanet
DisGeNETALKBH8
MedgenALKBH8
Genetic Testing Registry ALKBH8
NextProtQ96BT7 [Medical]
TSGene91801
GENETestsALKBH8
Target ValidationALKBH8
Huge Navigator ALKBH8 [HugePedia]
snp3D : Map Gene to Disease91801
BioCentury BCIQALKBH8
ClinGenALKBH8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91801
Chemical/Pharm GKB GenePA143485296
Clinical trialALKBH8
Miscellaneous
canSAR (ICR)ALKBH8 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALKBH8
EVEXALKBH8
GoPubMedALKBH8
iHOPALKBH8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:47 CET 2017

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