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ALKBH8 (alkB homolog 8, tRNA methyltransferase)

Identity

Alias (NCBI)ABH8
MRT71
TRM9
TRMT9
TRMT9A
HGNC (Hugo) ALKBH8
HGNC Alias symbMGC10235
TRM9
TRMT9A
HGNC Alias nametRNA methyltransferase 9 related
HGNC Previous namealkB, alkylation repair homolog 8 (E. coli)
LocusID (NCBI) 91801
Atlas_Id 43082
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 107502727 and ends at 107565735 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALKBH8 (11q22.3) / ALKBH8 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)ALKBH8   25189
Cards
Entrez_Gene (NCBI)ALKBH8    alkB homolog 8, tRNA methyltransferase
AliasesABH8; MRT71; TRM9; TRMT9; 
TRMT9A
GeneCards (Weizmann)ALKBH8
Ensembl hg19 (Hinxton)ENSG00000137760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137760 [Gene_View]  ENSG00000137760 [Sequence]  chr11:107502727-107565735 [Contig_View]  ALKBH8 [Vega]
ICGC DataPortalENSG00000137760
TCGA cBioPortalALKBH8
AceView (NCBI)ALKBH8
Genatlas (Paris)ALKBH8
SOURCE (Princeton)ALKBH8
Genetics Home Reference (NIH)ALKBH8
Genomic and cartography
GoldenPath hg38 (UCSC)ALKBH8  -     chr11:107502727-107565735 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALKBH8  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathALKBH8 - 11q22.3 [CytoView hg19]  ALKBH8 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000137760
Genome Data Viewer NCBIALKBH8 [Mapview hg19]  
OMIM613306   618504   
Gene and transcription
Genbank (Entrez)AB218768 AF086489 AK095523 AK293603 AK298800
RefSeq transcript (Entrez)NM_001301010 NM_001378133 NM_138775
Consensus coding sequences : CCDS (NCBI)ALKBH8
Gene ExpressionALKBH8 [ NCBI-GEO ]   ALKBH8 [ EBI - ARRAY_EXPRESS ]   ALKBH8 [ SEEK ]   ALKBH8 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH8 [ Firebrowse - Broad ]
GenevisibleExpression of ALKBH8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91801
GTEX Portal (Tissue expression)ALKBH8
Human Protein AtlasENSG00000137760-ALKBH8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BT7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BT7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BT7
PhosPhoSitePlusQ96BT7
Domaine pattern : Prosite (Expaxy)FE2OG_OXY (PS51471)   
Domains : Interpro (EBI)AlkB-like    AlkB_hom8_N    ALKBH8_RRM    Methyltransf_11    Nucleotide-bd_a/b_plait_sf    Oxoglu/Fe-dep_dioxygenase    RBD_domain_sf    SAM-dependent_MTases   
Domain families : Pfam (Sanger)2OG-FeII_Oxy_2 (PF13532)    DUF1891 (PF09004)    Methyltransf_11 (PF08241)   
Domain families : Pfam (NCBI)pfam13532    pfam09004    pfam08241   
Conserved Domain (NCBI)ALKBH8
PDB (RSDB)2CQ2    3THP    3THT   
PDB Europe2CQ2    3THP    3THT   
PDB (PDBSum)2CQ2    3THP    3THT   
PDB (IMB)2CQ2    3THP    3THT   
Structural Biology KnowledgeBase2CQ2    3THP    3THT   
SCOP (Structural Classification of Proteins)2CQ2    3THP    3THT   
CATH (Classification of proteins structures)2CQ2    3THP    3THT   
SuperfamilyQ96BT7
AlphaFold pdb e-kbQ96BT7   
Human Protein Atlas [tissue]ENSG00000137760-ALKBH8 [tissue]
HPRD14287
Protein Interaction databases
DIP (DOE-UCLA)Q96BT7
IntAct (EBI)Q96BT7
BioGRIDALKBH8
STRING (EMBL)ALKBH8
ZODIACALKBH8
Ontologies - Pathways
QuickGOQ96BT7
Ontology : AmiGOtRNA binding  tRNA binding  tRNA wobble uridine modification  tRNA wobble uridine modification  tRNA wobble uridine modification  iron ion binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  cellular response to DNA damage stimulus  zinc ion binding  tRNA (uracil) methyltransferase activity  nuclear body  2-oxoglutarate-dependent dioxygenase activity  tRNA methylation  tRNA methylation  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity  
Ontology : EGO-EBItRNA binding  tRNA binding  tRNA wobble uridine modification  tRNA wobble uridine modification  tRNA wobble uridine modification  iron ion binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  cellular response to DNA damage stimulus  zinc ion binding  tRNA (uracil) methyltransferase activity  nuclear body  2-oxoglutarate-dependent dioxygenase activity  tRNA methylation  tRNA methylation  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity  
NDEx NetworkALKBH8
Atlas of Cancer Signalling NetworkALKBH8
Wikipedia pathwaysALKBH8
Orthology - Evolution
OrthoDB91801
GeneTree (enSembl)ENSG00000137760
Phylogenetic Trees/Animal Genes : TreeFamALKBH8
Homologs : HomoloGeneALKBH8
Homology/Alignments : Family Browser (UCSC)ALKBH8
Gene fusions - Rearrangements
Fusion : QuiverALKBH8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKBH8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKBH8
dbVarALKBH8
ClinVarALKBH8
MonarchALKBH8
1000_GenomesALKBH8 
Exome Variant ServerALKBH8
GNOMAD BrowserENSG00000137760
Varsome BrowserALKBH8
ACMGALKBH8 variants
VarityQ96BT7
Genomic Variants (DGV)ALKBH8 [DGVbeta]
DECIPHERALKBH8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALKBH8 
Mutations
ICGC Data PortalALKBH8 
TCGA Data PortalALKBH8 
Broad Tumor PortalALKBH8
OASIS PortalALKBH8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALKBH8
Mutations and Diseases : HGMDALKBH8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaALKBH8
DgiDB (Drug Gene Interaction Database)ALKBH8
DoCM (Curated mutations)ALKBH8
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH8
Cancer3DALKBH8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613306    618504   
Orphanet
DisGeNETALKBH8
MedgenALKBH8
Genetic Testing Registry ALKBH8
NextProtQ96BT7 [Medical]
GENETestsALKBH8
Target ValidationALKBH8
Huge Navigator ALKBH8 [HugePedia]
ClinGenALKBH8
Clinical trials, drugs, therapy
MyCancerGenomeALKBH8
Protein Interactions : CTDALKBH8
Pharm GKB GenePA143485296
PharosQ96BT7
Clinical trialALKBH8
Miscellaneous
canSAR (ICR)ALKBH8
HarmonizomeALKBH8
DataMed IndexALKBH8
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALKBH8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:09 CEST 2021
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