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ALOX12B (arachidonate 12-lipoxygenase, 12R type)

Identity

Alias (NCBI)12R-LOX
ARCI2
HGNC (Hugo) ALOX12B
HGNC Alias symb12R-LOX
HGNC Alias name12R-lipoxygenase
LocusID (NCBI) 242
Atlas_Id 51324
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8072636 and ends at 8087716 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)ALOX12B   430
Cards
Entrez_Gene (NCBI)ALOX12B  242  arachidonate 12-lipoxygenase, 12R type
Aliases12R-LOX; ARCI2
GeneCards (Weizmann)ALOX12B
Ensembl hg19 (Hinxton)ENSG00000179477 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179477 [Gene_View]  ENSG00000179477 [Sequence]  chr17:8072636-8087716 [Contig_View]  ALOX12B [Vega]
ICGC DataPortalENSG00000179477
TCGA cBioPortalALOX12B
AceView (NCBI)ALOX12B
Genatlas (Paris)ALOX12B
WikiGenes242
SOURCE (Princeton)ALOX12B
Genetics Home Reference (NIH)ALOX12B
Genomic and cartography
GoldenPath hg38 (UCSC)ALOX12B  -     chr17:8072636-8087716 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALOX12B  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathALOX12B - 17p13.1 [CytoView hg19]  ALOX12B - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000179477
genome Data Viewer NCBIALOX12B [Mapview hg19]  
OMIM242100   603741   
Gene and transcription
Genbank (Entrez)AF038461 AF059250 BC041058
RefSeq transcript (Entrez)NM_001139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALOX12B
Alternative Splicing GalleryENSG00000179477
Gene ExpressionALOX12B [ NCBI-GEO ]   ALOX12B [ EBI - ARRAY_EXPRESS ]   ALOX12B [ SEEK ]   ALOX12B [ MEM ]
Gene Expression Viewer (FireBrowse)ALOX12B [ Firebrowse - Broad ]
GenevisibleExpression of ALOX12B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)242
GTEX Portal (Tissue expression)ALOX12B
Human Protein AtlasENSG00000179477-ALOX12B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75342   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75342  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75342
Splice isoforms : SwissVarO75342
PhosPhoSitePlusO75342
Domaine pattern : Prosite (Expaxy)LIPOXYGENASE_1 (PS00711)    LIPOXYGENASE_2 (PS00081)    LIPOXYGENASE_3 (PS51393)    PLAT (PS50095)   
Domains : Interpro (EBI)LipOase    LipOase_C    LipOase_C_sf    LipOase_CS    LipOase_Fe_BS    LipOase_mml    PLAT/LH2_dom    PLAT/LH2_dom_sf    PLAT_LOX_verte   
Domain families : Pfam (Sanger)Lipoxygenase (PF00305)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00305    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)ALOX12B
DMDM Disease mutations242
Blocks (Seattle)ALOX12B
SuperfamilyO75342
Human Protein Atlas [tissue]ENSG00000179477-ALOX12B [tissue]
Peptide AtlasO75342
HPRD04772
IPIIPI00025278   
Protein Interaction databases
DIP (DOE-UCLA)O75342
IntAct (EBI)O75342
FunCoupENSG00000179477
BioGRIDALOX12B
STRING (EMBL)ALOX12B
ZODIACALOX12B
Ontologies - Pathways
QuickGOO75342
Ontology : AmiGOarachidonate 12-lipoxygenase activity  arachidonate 12-lipoxygenase activity  iron ion binding  protein binding  cytosol  protein lipidation  sphingolipid metabolic process  positive regulation of gene expression  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  lyase activity  isomerase activity  arachidonic acid metabolic process  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  lipid oxidation  positive regulation of MAPK cascade  linoleic acid metabolic process  linoleic acid metabolic process  ceramide biosynthetic process  arachidonate 8(R)-lipoxygenase activity  perinuclear region of cytoplasm  perinuclear region of cytoplasm  hepoxilin biosynthetic process  hepoxilin biosynthetic process  oxidation-reduction process  oxidation-reduction process  establishment of skin barrier  positive regulation of mucus secretion  linoleate 9S-lipoxygenase activity  
Ontology : EGO-EBIarachidonate 12-lipoxygenase activity  arachidonate 12-lipoxygenase activity  iron ion binding  protein binding  cytosol  protein lipidation  sphingolipid metabolic process  positive regulation of gene expression  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  lyase activity  isomerase activity  arachidonic acid metabolic process  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  lipid oxidation  positive regulation of MAPK cascade  linoleic acid metabolic process  linoleic acid metabolic process  ceramide biosynthetic process  arachidonate 8(R)-lipoxygenase activity  perinuclear region of cytoplasm  perinuclear region of cytoplasm  hepoxilin biosynthetic process  hepoxilin biosynthetic process  oxidation-reduction process  oxidation-reduction process  establishment of skin barrier  positive regulation of mucus secretion  linoleate 9S-lipoxygenase activity  
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
NDEx NetworkALOX12B
Atlas of Cancer Signalling NetworkALOX12B
Wikipedia pathwaysALOX12B
Orthology - Evolution
OrthoDB242
GeneTree (enSembl)ENSG00000179477
Phylogenetic Trees/Animal Genes : TreeFamALOX12B
HOGENOMO75342
Homologs : HomoloGeneALOX12B
Homology/Alignments : Family Browser (UCSC)ALOX12B
Gene fusions - Rearrangements
Fusion : QuiverALOX12B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALOX12B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALOX12B
dbVarALOX12B
ClinVarALOX12B
MonarchALOX12B
1000_GenomesALOX12B 
Exome Variant ServerALOX12B
GNOMAD BrowserENSG00000179477
Varsome BrowserALOX12B
Genetic variants : HAPMAP242
Genomic Variants (DGV)ALOX12B [DGVbeta]
DECIPHERALOX12B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALOX12B 
Mutations
ICGC Data PortalALOX12B 
TCGA Data PortalALOX12B 
Broad Tumor PortalALOX12B
OASIS PortalALOX12B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALOX12B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALOX12B
Mutations and Diseases : HGMDALOX12B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALOX12B
DgiDB (Drug Gene Interaction Database)ALOX12B
DoCM (Curated mutations)ALOX12B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALOX12B (select a term)
intoGenALOX12B
Cancer3DALOX12B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM242100    603741   
Orphanet265    20528    11420   
DisGeNETALOX12B
MedgenALOX12B
Genetic Testing Registry ALOX12B
NextProtO75342 [Medical]
TSGene242
GENETestsALOX12B
Target ValidationALOX12B
Huge Navigator ALOX12B [HugePedia]
snp3D : Map Gene to Disease242
BioCentury BCIQALOX12B
ClinGenALOX12B
Clinical trials, drugs, therapy
Protein Interactions : CTD242
Pharm GKB GenePA24722
Clinical trialALOX12B
Miscellaneous
canSAR (ICR)ALOX12B (select the gene name)
HarmonizomeALOX12B
DataMed IndexALOX12B
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALOX12B
EVEXALOX12B
GoPubMedALOX12B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:01:13 CEST 2020

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