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ALOX12B (arachidonate 12-lipoxygenase, 12R type)

Identity

Other names12R-LOX
ARCI2
HGNC (Hugo) ALOX12B
LocusID (NCBI) 242
Location 17p13.1
Location_base_pair Starts at 7975954 and ends at 7991021 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ALOX12B   430
Cards
Entrez_Gene (NCBI)ALOX12B  242  arachidonate 12-lipoxygenase, 12R type
GeneCards (Weizmann)ALOX12B
Ensembl (Hinxton)ENSG00000179477 [Gene_View]  chr17:7975954-7991021 [Contig_View]  ALOX12B [Vega]
ICGC DataPortalENSG00000179477
cBioPortalALOX12B
AceView (NCBI)ALOX12B
Genatlas (Paris)ALOX12B
WikiGenes242
SOURCE (Princeton)NM_001139
Genomic and cartography
GoldenPath (UCSC)ALOX12B  -  17p13.1   chr17:7975954-7991021 -  17p13.1   [Description]    (hg19-Feb_2009)
EnsemblALOX12B - 17p13.1 [CytoView]
Mapping of homologs : NCBIALOX12B [Mapview]
OMIM242100   603741   
Gene and transcription
Genbank (Entrez)AF038461 AF059250 BC041058
RefSeq transcript (Entrez)NM_001139
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_007099 NT_010718 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)ALOX12B
Cluster EST : UnigeneHs.136574 [ NCBI ]
CGAP (NCI)Hs.136574
Alternative Splicing : Fast-db (Paris)GSHG0013066
Alternative Splicing GalleryENSG00000179477
Gene ExpressionALOX12B [ NCBI-GEO ]     ALOX12B [ SEEK ]   ALOX12B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75342 (Uniprot)
NextProtO75342  [Medical]
With graphics : InterProO75342
Splice isoforms : SwissVarO75342 (Swissvar)
Catalytic activity : Enzyme1.13.11.- [ Enzyme-Expasy ]   1.13.11.-1.13.11.- [ IntEnz-EBI ]   1.13.11.- [ BRENDA ]   1.13.11.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)LIPOXYGENASE_1 (PS00711)    LIPOXYGENASE_2 (PS00081)    LIPOXYGENASE_3 (PS51393)    PLAT (PS50095)   
Domains : Interpro (EBI)Lipase_LipOase [organisation]   LipOase [organisation]   LipOase_C [organisation]   LipOase_CS [organisation]   LipOase_Fe_BS [organisation]   LipOase_mml [organisation]   PLAT/LH2_dom [organisation]  
Related proteins : CluSTrO75342
Domain families : Pfam (Sanger)Lipoxygenase (PF00305)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00305    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
DMDM Disease mutations242
Blocks (Seattle)O75342
Human Protein AtlasENSG00000179477 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO75342
HPRD04772
IPIIPI00025278   
Protein Interaction databases
DIP (DOE-UCLA)O75342
IntAct (EBI)O75342
FunCoupENSG00000179477
BioGRIDALOX12B
InParanoidO75342
Interologous Interaction database O75342
IntegromeDBALOX12B
STRING (EMBL)ALOX12B
Ontologies - Pathways
Ontology : AmiGOarachidonate 12-lipoxygenase activity  arachidonate 12-lipoxygenase activity  iron ion binding  protein binding  cytosol  protein lipidation  sphingolipid metabolic process  positive regulation of gene expression  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  positive regulation of MAPK cascade  linoleic acid metabolic process  small molecule metabolic process  ceramide biosynthetic process  hepoxilin biosynthetic process  oxidation-reduction process  oxidation-reduction process  establishment of skin barrier  positive regulation of mucus secretion  linoleate 9S-lipoxygenase activity  
Ontology : EGO-EBIarachidonate 12-lipoxygenase activity  arachidonate 12-lipoxygenase activity  iron ion binding  protein binding  cytosol  protein lipidation  sphingolipid metabolic process  positive regulation of gene expression  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  lipoxygenase pathway  positive regulation of MAPK cascade  linoleic acid metabolic process  small molecule metabolic process  ceramide biosynthetic process  hepoxilin biosynthetic process  oxidation-reduction process  oxidation-reduction process  establishment of skin barrier  positive regulation of mucus secretion  linoleate 9S-lipoxygenase activity  
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
Protein Interaction DatabaseALOX12B
Wikipedia pathwaysALOX12B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ALOX12B
snp3D : Map Gene to Disease242
SNP (GeneSNP Utah)ALOX12B
SNP : HGBaseALOX12B
Genetic variants : HAPMAPALOX12B
Exome VariantALOX12B
1000_GenomesALOX12B 
ICGC programENSG00000179477 
Somatic Mutations in Cancer : COSMICALOX12B 
CONAN: Copy Number AnalysisALOX12B 
Mutations and Diseases : HGMDALOX12B
Mutations and Diseases : intOGenALOX12B
Genomic VariantsALOX12B  ALOX12B [DGVbeta]
dbVarALOX12B
ClinVarALOX12B
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM242100    603741   
MedgenALOX12B
GENETestsALOX12B
Disease Genetic AssociationALOX12B
Huge Navigator ALOX12B [HugePedia]  ALOX12B [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneALOX12B
Homology/Alignments : Family Browser (UCSC)ALOX12B
Phylogenetic Trees/Animal Genes : TreeFamALOX12B
Chemical/Protein Interactions : CTD242
Chemical/Pharm GKB GenePA24722
Clinical trialALOX12B
Cancer Resource (Charite)ENSG00000179477
Other databases
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
CoreMineALOX12B
iHOPALOX12B
OncoSearchALOX12B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:37:53 CEST 2014

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