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ALOX15B (arachidonate 15-lipoxygenase, type B)

Identity

Other names15-LOX-2
HGNC (Hugo) ALOX15B
LocusID (NCBI) 247
Location 17p13.1
Location_base_pair Starts at 7942358 and ends at 7952451 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ALOX15B   434
Cards
Entrez_Gene (NCBI)ALOX15B  247  arachidonate 15-lipoxygenase, type B
GeneCards (Weizmann)ALOX15B
Ensembl (Hinxton)ENSG00000179593 [Gene_View]  chr17:7942358-7952451 [Contig_View]  ALOX15B [Vega]
ICGC DataPortalENSG00000179593
cBioPortalALOX15B
AceView (NCBI)ALOX15B
Genatlas (Paris)ALOX15B
WikiGenes247
SOURCE (Princeton)NM_001039130 NM_001039131 NM_001141
Genomic and cartography
GoldenPath (UCSC)ALOX15B  -  17p13.1   chr17:7942358-7952451 +  17p13.1   [Description]    (hg19-Feb_2009)
EnsemblALOX15B - 17p13.1 [CytoView]
Mapping of homologs : NCBIALOX15B [Mapview]
OMIM603697   
Gene and transcription
Genbank (Entrez)AF468051 AF468052 AF468053 AF468054 AK292779
RefSeq transcript (Entrez)NM_001039130 NM_001039131 NM_001141
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_029482 NT_010718 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)ALOX15B
Cluster EST : UnigeneHs.111256 [ NCBI ]
CGAP (NCI)Hs.111256
Alternative Splicing : Fast-db (Paris)GSHG0012213
Alternative Splicing GalleryENSG00000179593
Gene ExpressionALOX15B [ NCBI-GEO ]     ALOX15B [ SEEK ]   ALOX15B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15296 (Uniprot)
NextProtO15296  [Medical]
With graphics : InterProO15296
Splice isoforms : SwissVarO15296 (Swissvar)
Catalytic activity : Enzyme1.13.11.33 [ Enzyme-Expasy ]   1.13.11.331.13.11.33 [ IntEnz-EBI ]   1.13.11.33 [ BRENDA ]   1.13.11.33 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)LIPOXYGENASE_1 (PS00711)    LIPOXYGENASE_2 (PS00081)    LIPOXYGENASE_3 (PS51393)    PLAT (PS50095)   
Domains : Interpro (EBI)Lipase_LipOase [organisation]   LipOase [organisation]   LipOase_C [organisation]   LipOase_CS [organisation]   LipOase_Fe_BS [organisation]   LipOase_mml [organisation]   PLAT/LH2_dom [organisation]  
Related proteins : CluSTrO15296
Domain families : Pfam (Sanger)Lipoxygenase (PF00305)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00305    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
DMDM Disease mutations247
Blocks (Seattle)O15296
PDB (SRS)4NRE   
PDB (PDBSum)4NRE   
PDB (IMB)4NRE   
PDB (RSDB)4NRE   
Human Protein AtlasENSG00000179593 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO15296
HPRD04739
IPIIPI00005781   IPI00220009   IPI00220010   IPI00470667   
Protein Interaction databases
DIP (DOE-UCLA)O15296
IntAct (EBI)O15296
FunCoupENSG00000179593
BioGRIDALOX15B
InParanoidO15296
Interologous Interaction database O15296
IntegromeDBALOX15B
STRING (EMBL)ALOX15B
Ontologies - Pathways
Ontology : AmiGOiron ion binding  calcium ion binding  intracellular  nucleus  nucleus  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  lipid metabolic process  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  positive regulation of macrophage derived foam cell differentiation  membrane  linoleate 13S-lipoxygenase activity  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  extrinsic component of membrane  negative regulation of cell migration  prostate gland development  regulation of epithelial cell differentiation  positive regulation of peroxisome proliferator activated receptor signaling pathway  arachidonate 8(S)-lipoxygenase activity  linoleic acid metabolic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  negative regulation of cell cycle  negative regulation of growth  arachidonate 15-lipoxygenase activity  hepoxilin biosynthetic process  oxidation-reduction process  positive regulation of chemokine secretion  
Ontology : EGO-EBIiron ion binding  calcium ion binding  intracellular  nucleus  nucleus  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  plasma membrane  lipid metabolic process  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  positive regulation of macrophage derived foam cell differentiation  membrane  linoleate 13S-lipoxygenase activity  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  extrinsic component of membrane  negative regulation of cell migration  prostate gland development  regulation of epithelial cell differentiation  positive regulation of peroxisome proliferator activated receptor signaling pathway  arachidonate 8(S)-lipoxygenase activity  linoleic acid metabolic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  negative regulation of cell cycle  negative regulation of growth  arachidonate 15-lipoxygenase activity  hepoxilin biosynthetic process  oxidation-reduction process  positive regulation of chemokine secretion  
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
Protein Interaction DatabaseALOX15B
Wikipedia pathwaysALOX15B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ALOX15B
snp3D : Map Gene to Disease247
SNP (GeneSNP Utah)ALOX15B
SNP : HGBaseALOX15B
Genetic variants : HAPMAPALOX15B
Exome VariantALOX15B
1000_GenomesALOX15B 
ICGC programENSG00000179593 
Somatic Mutations in Cancer : COSMICALOX15B 
CONAN: Copy Number AnalysisALOX15B 
Mutations and Diseases : HGMDALOX15B
Genomic VariantsALOX15B  ALOX15B [DGVbeta]
dbVarALOX15B
ClinVarALOX15B
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603697   
MedgenALOX15B
GENETestsALOX15B
Disease Genetic AssociationALOX15B
Huge Navigator ALOX15B [HugePedia]  ALOX15B [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneALOX15B
Homology/Alignments : Family Browser (UCSC)ALOX15B
Phylogenetic Trees/Animal Genes : TreeFamALOX15B
Chemical/Protein Interactions : CTD247
Chemical/Pharm GKB GenePA24725
Clinical trialALOX15B
Cancer Resource (Charite)ENSG00000179593
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineALOX15B
iHOPALOX15B
OncoSearchALOX15B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:42:34 CEST 2014

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