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ALOX15B (arachidonate 15-lipoxygenase type B)

Identity

Alias (NCBI)15-LOX-2
HGNC (Hugo) ALOX15B
HGNC Alias symb15-LOX-2
HGNC Previous namearachidonate 15-lipoxygenase, second type
LocusID (NCBI) 247
Atlas_Id 42987
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8039059 and ends at 8049133 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALOX15B (17p13.1) / CAPNS1 (19q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)ALOX15B   434
Cards
Entrez_Gene (NCBI)ALOX15B  247  arachidonate 15-lipoxygenase type B
Aliases15-LOX-2
GeneCards (Weizmann)ALOX15B
Ensembl hg19 (Hinxton)ENSG00000179593 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179593 [Gene_View]  ENSG00000179593 [Sequence]  chr17:8039059-8049133 [Contig_View]  ALOX15B [Vega]
ICGC DataPortalENSG00000179593
TCGA cBioPortalALOX15B
AceView (NCBI)ALOX15B
Genatlas (Paris)ALOX15B
WikiGenes247
SOURCE (Princeton)ALOX15B
Genetics Home Reference (NIH)ALOX15B
Genomic and cartography
GoldenPath hg38 (UCSC)ALOX15B  -     chr17:8039059-8049133 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALOX15B  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathALOX15B - 17p13.1 [CytoView hg19]  ALOX15B - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000179593
genome Data Viewer NCBIALOX15B [Mapview hg19]  
OMIM603697   
Gene and transcription
Genbank (Entrez)AF468051 AF468052 AF468053 AF468054 AK292779
RefSeq transcript (Entrez)NM_001039130 NM_001039131 NM_001141
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALOX15B
Alternative Splicing GalleryENSG00000179593
Gene ExpressionALOX15B [ NCBI-GEO ]   ALOX15B [ EBI - ARRAY_EXPRESS ]   ALOX15B [ SEEK ]   ALOX15B [ MEM ]
Gene Expression Viewer (FireBrowse)ALOX15B [ Firebrowse - Broad ]
GenevisibleExpression of ALOX15B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)247
GTEX Portal (Tissue expression)ALOX15B
Human Protein AtlasENSG00000179593-ALOX15B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15296   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15296  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15296
Splice isoforms : SwissVarO15296
Catalytic activity : Enzyme1.13.11.33 [ Enzyme-Expasy ]   1.13.11.331.13.11.33 [ IntEnz-EBI ]   1.13.11.33 [ BRENDA ]   1.13.11.33 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO15296
Domaine pattern : Prosite (Expaxy)LIPOXYGENASE_1 (PS00711)    LIPOXYGENASE_2 (PS00081)    LIPOXYGENASE_3 (PS51393)    PLAT (PS50095)   
Domains : Interpro (EBI)LipOase    LipOase_C    LipOase_C_sf    LipOase_CS    LipOase_Fe_BS    LipOase_mml    PLAT/LH2_dom    PLAT/LH2_dom_sf    PLAT_LOX_verte   
Domain families : Pfam (Sanger)Lipoxygenase (PF00305)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00305    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)ALOX15B
DMDM Disease mutations247
Blocks (Seattle)ALOX15B
PDB (RSDB)4NRE   
PDB Europe4NRE   
PDB (PDBSum)4NRE   
PDB (IMB)4NRE   
Structural Biology KnowledgeBase4NRE   
SCOP (Structural Classification of Proteins)4NRE   
CATH (Classification of proteins structures)4NRE   
SuperfamilyO15296
Human Protein Atlas [tissue]ENSG00000179593-ALOX15B [tissue]
Peptide AtlasO15296
HPRD04739
IPIIPI00005781   IPI00220009   IPI00220010   IPI00470667   
Protein Interaction databases
DIP (DOE-UCLA)O15296
IntAct (EBI)O15296
FunCoupENSG00000179593
BioGRIDALOX15B
STRING (EMBL)ALOX15B
ZODIACALOX15B
Ontologies - Pathways
QuickGOO15296
Ontology : AmiGOiron ion binding  calcium ion binding  nucleus  cytosol  cytosol  cytoskeleton  plasma membrane  adherens junction  focal adhesion  lipid metabolic process  lipid metabolic process  phospholipid metabolic process  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  positive regulation of macrophage derived foam cell differentiation  membrane  linoleate 13S-lipoxygenase activity  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  extrinsic component of membrane  negative regulation of cell migration  prostate gland development  regulation of epithelial cell differentiation  lipid oxidation  positive regulation of peroxisome proliferator activated receptor signaling pathway  arachidonate 8(S)-lipoxygenase activity  linoleic acid metabolic process  positive regulation of keratinocyte differentiation  negative regulation of cell cycle  negative regulation of growth  arachidonate 15-lipoxygenase activity  arachidonate 15-lipoxygenase activity  hepoxilin biosynthetic process  hepoxilin biosynthetic process  extracellular exosome  endocannabinoid signaling pathway  positive regulation of chemokine secretion  cannabinoid biosynthetic process  lipoxin A4 biosynthetic process  
Ontology : EGO-EBIiron ion binding  calcium ion binding  nucleus  cytosol  cytosol  cytoskeleton  plasma membrane  adherens junction  focal adhesion  lipid metabolic process  lipid metabolic process  phospholipid metabolic process  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  positive regulation of macrophage derived foam cell differentiation  membrane  linoleate 13S-lipoxygenase activity  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  lipoxygenase pathway  lipoxygenase pathway  extrinsic component of membrane  negative regulation of cell migration  prostate gland development  regulation of epithelial cell differentiation  lipid oxidation  positive regulation of peroxisome proliferator activated receptor signaling pathway  arachidonate 8(S)-lipoxygenase activity  linoleic acid metabolic process  positive regulation of keratinocyte differentiation  negative regulation of cell cycle  negative regulation of growth  arachidonate 15-lipoxygenase activity  arachidonate 15-lipoxygenase activity  hepoxilin biosynthetic process  hepoxilin biosynthetic process  extracellular exosome  endocannabinoid signaling pathway  positive regulation of chemokine secretion  cannabinoid biosynthetic process  lipoxin A4 biosynthetic process  
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
NDEx NetworkALOX15B
Atlas of Cancer Signalling NetworkALOX15B
Wikipedia pathwaysALOX15B
Orthology - Evolution
OrthoDB247
GeneTree (enSembl)ENSG00000179593
Phylogenetic Trees/Animal Genes : TreeFamALOX15B
HOGENOMO15296
Homologs : HomoloGeneALOX15B
Homology/Alignments : Family Browser (UCSC)ALOX15B
Gene fusions - Rearrangements
Fusion : QuiverALOX15B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALOX15B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALOX15B
dbVarALOX15B
ClinVarALOX15B
MonarchALOX15B
1000_GenomesALOX15B 
Exome Variant ServerALOX15B
GNOMAD BrowserENSG00000179593
Varsome BrowserALOX15B
Genetic variants : HAPMAP247
Genomic Variants (DGV)ALOX15B [DGVbeta]
DECIPHERALOX15B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALOX15B 
Mutations
ICGC Data PortalALOX15B 
TCGA Data PortalALOX15B 
Broad Tumor PortalALOX15B
OASIS PortalALOX15B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALOX15B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALOX15B
Mutations and Diseases : HGMDALOX15B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALOX15B
DgiDB (Drug Gene Interaction Database)ALOX15B
DoCM (Curated mutations)ALOX15B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALOX15B (select a term)
intoGenALOX15B
Cancer3DALOX15B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603697   
Orphanet
DisGeNETALOX15B
MedgenALOX15B
Genetic Testing Registry ALOX15B
NextProtO15296 [Medical]
TSGene247
GENETestsALOX15B
Target ValidationALOX15B
Huge Navigator ALOX15B [HugePedia]
snp3D : Map Gene to Disease247
BioCentury BCIQALOX15B
ClinGenALOX15B
Clinical trials, drugs, therapy
Protein Interactions : CTD247
Pharm GKB GenePA24725
Clinical trialALOX15B
Miscellaneous
canSAR (ICR)ALOX15B (select the gene name)
HarmonizomeALOX15B
DataMed IndexALOX15B
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALOX15B
EVEXALOX15B
GoPubMedALOX15B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:01:13 CEST 2020

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