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ALOX5AP (arachidonate 5-lipoxygenase activating protein)

Identity

Alias_namesarachidonate 5-lipoxygenase-activating protein
Alias_symbol (synonym)FLAP
Other alias
HGNC (Hugo) ALOX5AP
LocusID (NCBI) 241
Atlas_Id 621
Location 13q12.3  [Link to chromosome band 13q12]
Location_base_pair Starts at 30713478 and ends at 30764428 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCL4 (17q12) / ALOX5AP (13q12.3)VRK1 (14q32.2) / ALOX5AP (13q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALOX5AP   436
Cards
Entrez_Gene (NCBI)ALOX5AP  241  arachidonate 5-lipoxygenase activating protein
AliasesFLAP
GeneCards (Weizmann)ALOX5AP
Ensembl hg19 (Hinxton)ENSG00000132965 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132965 [Gene_View]  chr13:30713478-30764428 [Contig_View]  ALOX5AP [Vega]
ICGC DataPortalENSG00000132965
TCGA cBioPortalALOX5AP
AceView (NCBI)ALOX5AP
Genatlas (Paris)ALOX5AP
WikiGenes241
SOURCE (Princeton)ALOX5AP
Genetics Home Reference (NIH)ALOX5AP
Genomic and cartography
GoldenPath hg38 (UCSC)ALOX5AP  -     chr13:30713478-30764428 +  13q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALOX5AP  -     13q12.3   [Description]    (hg19-Feb_2009)
EnsemblALOX5AP - 13q12.3 [CytoView hg19]  ALOX5AP - 13q12.3 [CytoView hg38]
Mapping of homologs : NCBIALOX5AP [Mapview hg19]  ALOX5AP [Mapview hg38]
OMIM601367   603700   
Gene and transcription
Genbank (Entrez)AK314143 BC018538 BG569867 BQ003388 DQ891647
RefSeq transcript (Entrez)NM_001204406 NM_001629
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALOX5AP
Cluster EST : UnigeneHs.507658 [ NCBI ]
CGAP (NCI)Hs.507658
Alternative Splicing GalleryENSG00000132965
Gene ExpressionALOX5AP [ NCBI-GEO ]   ALOX5AP [ EBI - ARRAY_EXPRESS ]   ALOX5AP [ SEEK ]   ALOX5AP [ MEM ]
Gene Expression Viewer (FireBrowse)ALOX5AP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)241
GTEX Portal (Tissue expression)ALOX5AP
Human Protein AtlasENSG00000132965-ALOX5AP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20292   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20292
Splice isoforms : SwissVarP20292
PhosPhoSitePlusP20292
Domaine pattern : Prosite (Expaxy)FLAP_GST2_LTC4S (PS01297)   
Domains : Interpro (EBI)5_LipOase_AP    FLAP/GST2/LTC4S_CS    MAPEG-like_dom    Membr-assoc_MAPEG   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
Conserved Domain (NCBI)ALOX5AP
DMDM Disease mutations241
Blocks (Seattle)ALOX5AP
PDB (SRS)2Q7M    2Q7R   
PDB (PDBSum)2Q7M    2Q7R   
PDB (IMB)2Q7M    2Q7R   
PDB (RSDB)2Q7M    2Q7R   
Structural Biology KnowledgeBase2Q7M    2Q7R   
SCOP (Structural Classification of Proteins)2Q7M    2Q7R   
CATH (Classification of proteins structures)2Q7M    2Q7R   
SuperfamilyP20292
Human Protein Atlas [tissue]ENSG00000132965-ALOX5AP [tissue]
Peptide AtlasP20292
HPRD04742
IPIIPI00022975   IPI00982495   
Protein Interaction databases
DIP (DOE-UCLA)P20292
IntAct (EBI)P20292
FunCoupENSG00000132965
BioGRIDALOX5AP
STRING (EMBL)ALOX5AP
ZODIACALOX5AP
Ontologies - Pathways
QuickGOP20292
Ontology : AmiGOglutathione transferase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  protein binding  nuclear envelope  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum membrane  leukotriene metabolic process  enzyme activator activity  membrane  integral component of membrane  leukotriene biosynthetic process  lipoxygenase pathway  nuclear membrane  positive regulation of catalytic activity  protein N-terminus binding  arachidonic acid binding  protein homotrimerization  cellular response to calcium ion  lipoxin metabolic process  
Ontology : EGO-EBIglutathione transferase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  protein binding  nuclear envelope  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum membrane  leukotriene metabolic process  enzyme activator activity  membrane  integral component of membrane  leukotriene biosynthetic process  lipoxygenase pathway  nuclear membrane  positive regulation of catalytic activity  protein N-terminus binding  arachidonic acid binding  protein homotrimerization  cellular response to calcium ion  lipoxin metabolic process  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
NDEx NetworkALOX5AP
Atlas of Cancer Signalling NetworkALOX5AP
Wikipedia pathwaysALOX5AP
Orthology - Evolution
OrthoDB241
GeneTree (enSembl)ENSG00000132965
Phylogenetic Trees/Animal Genes : TreeFamALOX5AP
HOVERGENP20292
HOGENOMP20292
Homologs : HomoloGeneALOX5AP
Homology/Alignments : Family Browser (UCSC)ALOX5AP
Gene fusions - Rearrangements
Tumor Fusion PortalALOX5AP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALOX5AP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALOX5AP
dbVarALOX5AP
ClinVarALOX5AP
1000_GenomesALOX5AP 
Exome Variant ServerALOX5AP
ExAC (Exome Aggregation Consortium)ENSG00000132965
GNOMAD BrowserENSG00000132965
Genetic variants : HAPMAP241
Genomic Variants (DGV)ALOX5AP [DGVbeta]
DECIPHERALOX5AP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALOX5AP 
Mutations
ICGC Data PortalALOX5AP 
TCGA Data PortalALOX5AP 
Broad Tumor PortalALOX5AP
OASIS PortalALOX5AP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALOX5AP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALOX5AP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALOX5AP
DgiDB (Drug Gene Interaction Database)ALOX5AP
DoCM (Curated mutations)ALOX5AP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALOX5AP (select a term)
intoGenALOX5AP
Cancer3DALOX5AP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601367    603700   
Orphanet
DisGeNETALOX5AP
MedgenALOX5AP
Genetic Testing Registry ALOX5AP
NextProtP20292 [Medical]
TSGene241
GENETestsALOX5AP
Target ValidationALOX5AP
Huge Navigator ALOX5AP [HugePedia]
snp3D : Map Gene to Disease241
BioCentury BCIQALOX5AP
ClinGenALOX5AP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD241
Chemical/Pharm GKB GenePA47
Clinical trialALOX5AP
Miscellaneous
canSAR (ICR)ALOX5AP (select the gene name)
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALOX5AP
EVEXALOX5AP
GoPubMedALOX5AP
iHOPALOX5AP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:49 CET 2017

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