ALOX5AP (arachidonate 5-lipoxygenase activating protein)

2003-06-01  

Identity

HGNC
LOCATION
13q12.3
LOCUSID
ALIAS
FLAP
FUSION GENES

Other Information

Locus ID:

NCBI: 241
MIM: 603700
HGNC: 436
Ensembl: ENSG00000132965

Variants:

dbSNP: 241
ClinVar: 241
TCGA: ENSG00000132965
COSMIC: ALOX5AP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132965ENST00000380490P20292
ENSG00000132965ENST00000617770A0A087WW23

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Fc epsilon RI signaling pathwayKEGGko04664
Fc epsilon RI signaling pathwayKEGGhsa04664
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373448822023ALOX5AP suppresses osteosarcoma progression via Wnt/β-catenin/EMT pathway and associates with clinical prognosis and immune infiltration.0
373448822023ALOX5AP suppresses osteosarcoma progression via Wnt/β-catenin/EMT pathway and associates with clinical prognosis and immune infiltration.0
319922462020Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis.14
320272512020[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].1
321653052020The ALOXA5AP gene (rs38022789) is associated with diabetic nephropathy in Slovenian patients with type 2 diabetes mellitus.3
334546792020ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION.1
319922462020Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis.14
320272512020[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].1
321653052020The ALOXA5AP gene (rs38022789) is associated with diabetic nephropathy in Slovenian patients with type 2 diabetes mellitus.3
334546792020ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION.1
302919622019A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein.2
306787012019Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.5
302919622019A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein.2
306787012019Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.5
293929772018Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus.4

Citation

Dessen P

ALOX5AP (arachidonate 5-lipoxygenase activating protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/621/alox5ap