Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ALOXE3 (arachidonate lipoxygenase 3)

Identity

Alias_symbol (synonym)eLOX3
E-LOX
Other aliasARCI3
eLOX-3
HGNC (Hugo) ALOXE3
LocusID (NCBI) 59344
Atlas_Id 60264
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8095900 and ends at 8118916 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADGRB3 (6q12) / ALOXE3 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALOXE3   13743
Cards
Entrez_Gene (NCBI)ALOXE3  59344  arachidonate lipoxygenase 3
AliasesARCI3; E-LOX; eLOX-3; eLOX3
GeneCards (Weizmann)ALOXE3
Ensembl hg19 (Hinxton)ENSG00000179148 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179148 [Gene_View]  chr17:8095900-8118916 [Contig_View]  ALOXE3 [Vega]
ICGC DataPortalENSG00000179148
TCGA cBioPortalALOXE3
AceView (NCBI)ALOXE3
Genatlas (Paris)ALOXE3
WikiGenes59344
SOURCE (Princeton)ALOXE3
Genetics Home Reference (NIH)ALOXE3
Genomic and cartography
GoldenPath hg38 (UCSC)ALOXE3  -     chr17:8095900-8118916 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALOXE3  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblALOXE3 - 17p13.1 [CytoView hg19]  ALOXE3 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIALOXE3 [Mapview hg19]  ALOXE3 [Mapview hg38]
OMIM242100   606545   607206   
Gene and transcription
Genbank (Entrez)AF182218 AJ269499 AK292732 AK296416 AK299742
RefSeq transcript (Entrez)NM_001165960 NM_021628
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALOXE3
Cluster EST : UnigeneHs.232770 [ NCBI ]
CGAP (NCI)Hs.232770
Alternative Splicing GalleryENSG00000179148
Gene ExpressionALOXE3 [ NCBI-GEO ]   ALOXE3 [ EBI - ARRAY_EXPRESS ]   ALOXE3 [ SEEK ]   ALOXE3 [ MEM ]
Gene Expression Viewer (FireBrowse)ALOXE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59344
GTEX Portal (Tissue expression)ALOXE3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYJ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYJ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYJ1
Splice isoforms : SwissVarQ9BYJ1
PhosPhoSitePlusQ9BYJ1
Domaine pattern : Prosite (Expaxy)LIPOXYGENASE_1 (PS00711)    LIPOXYGENASE_2 (PS00081)    LIPOXYGENASE_3 (PS51393)    PLAT (PS50095)   
Domains : Interpro (EBI)LipOase    LipOase_C    LipOase_CS    LipOase_Fe_BS    LipOase_mml    PLAT/LH2_dom   
Domain families : Pfam (Sanger)Lipoxygenase (PF00305)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00305    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
Conserved Domain (NCBI)ALOXE3
DMDM Disease mutations59344
Blocks (Seattle)ALOXE3
SuperfamilyQ9BYJ1
Human Protein AtlasENSG00000179148
Peptide AtlasQ9BYJ1
HPRD06231
IPIIPI00946278   IPI00307549   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYJ1
IntAct (EBI)Q9BYJ1
FunCoupENSG00000179148
BioGRIDALOXE3
STRING (EMBL)ALOXE3
ZODIACALOXE3
Ontologies - Pathways
QuickGOQ9BYJ1
Ontology : AmiGOiron ion binding  protein binding  cytoplasm  sphingolipid metabolic process  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  lyase activity  sensory perception of pain  arachidonic acid metabolic process  lipoxygenase pathway  peroxisome proliferator activated receptor signaling pathway  linoleic acid metabolic process  fat cell differentiation  ceramide biosynthetic process  hepoxilin A3 synthase activity  hepoxilin biosynthetic process  oxidation-reduction process  establishment of skin barrier  
Ontology : EGO-EBIiron ion binding  protein binding  cytoplasm  sphingolipid metabolic process  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  lyase activity  sensory perception of pain  arachidonic acid metabolic process  lipoxygenase pathway  peroxisome proliferator activated receptor signaling pathway  linoleic acid metabolic process  fat cell differentiation  ceramide biosynthetic process  hepoxilin A3 synthase activity  hepoxilin biosynthetic process  oxidation-reduction process  establishment of skin barrier  
NDEx NetworkALOXE3
Atlas of Cancer Signalling NetworkALOXE3
Wikipedia pathwaysALOXE3
Orthology - Evolution
OrthoDB59344
GeneTree (enSembl)ENSG00000179148
Phylogenetic Trees/Animal Genes : TreeFamALOXE3
HOVERGENQ9BYJ1
HOGENOMQ9BYJ1
Homologs : HomoloGeneALOXE3
Homology/Alignments : Family Browser (UCSC)ALOXE3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALOXE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALOXE3
dbVarALOXE3
ClinVarALOXE3
1000_GenomesALOXE3 
Exome Variant ServerALOXE3
ExAC (Exome Aggregation Consortium)ALOXE3 (select the gene name)
Genetic variants : HAPMAP59344
Genomic Variants (DGV)ALOXE3 [DGVbeta]
DECIPHERALOXE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALOXE3 
Mutations
ICGC Data PortalALOXE3 
TCGA Data PortalALOXE3 
Broad Tumor PortalALOXE3
OASIS PortalALOXE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALOXE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALOXE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALOXE3
DgiDB (Drug Gene Interaction Database)ALOXE3
DoCM (Curated mutations)ALOXE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALOXE3 (select a term)
intoGenALOXE3
Cancer3DALOXE3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM242100    606545    607206   
Orphanet265    20528    11420   
MedgenALOXE3
Genetic Testing Registry ALOXE3
NextProtQ9BYJ1 [Medical]
TSGene59344
GENETestsALOXE3
Target ValidationALOXE3
Huge Navigator ALOXE3 [HugePedia]
snp3D : Map Gene to Disease59344
BioCentury BCIQALOXE3
ClinGenALOXE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59344
Chemical/Pharm GKB GenePA24727
Clinical trialALOXE3
Miscellaneous
canSAR (ICR)ALOXE3 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALOXE3
EVEXALOXE3
GoPubMedALOXE3
iHOPALOXE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:37:57 CEST 2017

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